2014
An Inherited Small Microdeletion at 15q13.3 in a Patient with Early- Onset Obsessive-Compulsive Disorder
Cappi C, Hounie A, Mariani D, Diniz J, Silva A, Reis V, Busso A, Silva A, Fidalgo F, Rogatto S, Miguel E, Krepischi A, Brentani H. An Inherited Small Microdeletion at 15q13.3 in a Patient with Early- Onset Obsessive-Compulsive Disorder. PLOS ONE 2014, 9: e110198. PMID: 25303678, PMCID: PMC4193873, DOI: 10.1371/journal.pone.0110198.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge of OnsetCase-Control StudiesChildChild, PreschoolChromosome DeletionChromosomes, Human, Pair 15Comparative Genomic HybridizationDNA Copy Number VariationsFetal ProteinsForminsGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMicrofilament ProteinsNuclear ProteinsObsessive-Compulsive DisorderConceptsObsessive-compulsive disorderOnset obsessive-compulsive disorderEarly-onset obsessive-compulsive disorderAttention deficit hyperactivity disorderArray-based comparative genomic hybridizationNeurodevelopmental psychiatric disordersDeficit hyperactivity disorderGlutamatergic involvementMale patientsGlutamatergic systemPsychiatric disordersHealthy individualsPatientsHyperactivity disorderGenetic riskComparative genomic hybridizationDisordersSmall microdeletionsChromosome 15q13.3Present studyGenomic hybridizationMicrodeletionCohort
2013
Late-onset obsessive-compulsive disorder: Risk factors and correlates
Frydman I, do Brasil PE, Torres AR, Shavitt RG, Ferrão YA, Rosário MC, Miguel EC, Fontenelle LF. Late-onset obsessive-compulsive disorder: Risk factors and correlates. Journal Of Psychiatric Research 2013, 49: 68-74. PMID: 24267559, DOI: 10.1016/j.jpsychires.2013.10.021.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderLate-onset obsessive-compulsive disorderSubclinical obsessive-compulsive symptomsPosttraumatic stress disorderObsessive-compulsive symptomsOnset obsessive-compulsive disorderObsessive-compulsive spectrum disordersMajor traumatic eventEarly-onset obsessive-compulsive disorderBrazilian Research ConsortiumTraumatic eventsSpectrum disorderStress disorderOCD symptomsOCD onsetDearth of studiesSelfCorrelatesDisordersPotential variablesNeural networkDistressSymptomsSizeable proportionSeries of models
2009
Early Onset Obsessive-Compulsive Disorder With and Without Tics
de Mathis M, Diniz J, Shavitt R, Torres A, Ferrão Y, Fossaluza V, Pereira C, Miguel E, do Rosario M. Early Onset Obsessive-Compulsive Disorder With and Without Tics. CNS Spectrums 2009, 14: 362-370. PMID: 19773712, DOI: 10.1017/s1092852900023014.Peer-Reviewed Original ResearchConceptsOnset obsessive-compulsive disorderObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleYears of ageEarly-onset obsessive-compulsive disorderObsessive Compulsive ScaleObsessive-compulsive symptomsTic disordersDimensional Yale-Brown Obsessive Compulsive ScaleYale Global Tic Severity ScaleCompulsive ScaleHigher mean scoresFourth Edition criteriaStructured Clinical InterviewTic Severity ScaleVariable clinical manifestationsMean score
2005
A family study of early‐onset obsessive‐compulsive disorder
do Rosario‐Campos M, Leckman JF, Curi M, Quatrano S, Katsovitch L, Miguel EC, Pauls DL. A family study of early‐onset obsessive‐compulsive disorder. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2005, 136B: 92-97. PMID: 15892140, DOI: 10.1002/ajmg.b.30149.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRecurrence riskChronic ticsFirst-degree family membersChildhood-onset obsessive-compulsive disorderDiagnosis of OCDChronic tic disorderStandardized semi-structured interviewFirst-degree relativesEarly-onset casesOnset obsessive-compulsive disorderDSM-IV criteriaEarly-onset obsessive-compulsive disorderBest-estimate processRandom digit dialingHigh comorbid ratesAge of onsetFamily studiesHigh genetic loadingMean ageSpecialty clinicTic disordersComorbid ratesValid subgroupsCase relatives
2001
Adults With Early-Onset Obsessive-Compulsive Disorder
Rosario-Campos MC, Leckman JF, Mercadante MT, Shavitt RG, Prado HS, Sada P, Zamignani D, Miguel EC. Adults With Early-Onset Obsessive-Compulsive Disorder. American Journal Of Psychiatry 2001, 158: 1899-1903. PMID: 11691698, DOI: 10.1176/appi.ajp.158.11.1899.Peer-Reviewed Original ResearchConceptsSymptom onsetObsessive-compulsive disorderSelective serotonin reuptake inhibitorsOCD patientsSerotonin reuptake inhibitorsEarlier symptom onsetEarly-onset groupLater symptom onsetOnset obsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleComorbid tic disordersAdult OCD patientsObsessive Compulsive ScaleReuptake inhibitorsAdult outpatientsTic disordersTreatment outcomesOCD symptom onsetBimodal ageEarly onsetHeterogeneous disorderCompulsive ScaleDisordersAgePatientsRegional Cerebral Blood Flow Abnormalities in Early-Onset Obsessive-Compulsive Disorder: An Exploratory SPECT Study
BUSATTO G, BUCHPIGUEL C, ZAMIGNANI D, GARRIDO G, GLABUS M, ROSARIO-CAMPOS M, CASTRO C, MAIA A, ROCHA E, MCGUIRE P, MIGUEL E. Regional Cerebral Blood Flow Abnormalities in Early-Onset Obsessive-Compulsive Disorder: An Exploratory SPECT Study. Journal Of The American Academy Of Child & Adolescent Psychiatry 2001, 40: 347-354. PMID: 11288777, DOI: 10.1097/00004583-200103000-00015.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderLate-onset subjectsOCD subjectsRegional cerebral blood flow (rCBF) single-photon emissionCerebral blood flow single photon emissionRegional cerebral blood flow abnormalitiesCerebral blood flow abnormalitiesObsessive-compulsive symptomsPathophysiology of OCDBlood flow abnormalitiesEarly-onset casesOnset obsessive-compulsive disorderFrontal-subcortical circuitsAge of onsetEarly-onset subjectsAnterior cingulate cortexPrefrontal cortex relativeSingle photon emissionStatistical parametric mappingRCBF differencesRight thalamusHealthy controlsFlow abnormalitiesClinical dataCortex relative