2024
Increases in functional connectivity between the default mode network and sensorimotor network correlate with symptomatic improvement after transcranial direct current stimulation for obsessive-compulsive disorder
Echevarria M, Batistuzzo M, Silva R, Brunoni A, Sato J, Miguel E, Hoexter M, Shavitt R. Increases in functional connectivity between the default mode network and sensorimotor network correlate with symptomatic improvement after transcranial direct current stimulation for obsessive-compulsive disorder. Journal Of Affective Disorders 2024, 355: 175-183. PMID: 38548207, DOI: 10.1016/j.jad.2024.03.141.Peer-Reviewed Original ResearchTranscranial direct current stimulationObsessive-compulsive disorderDirect current stimulationCurrent stimulationActive transcranial direct current stimulationSensorimotor networkOCD symptom dimensionsTreatment-resistant obsessive-compulsive disorderNeurobiological mechanisms of actionObsessive-compulsive disorder pathophysiologyWhole-brain connectivity analysisDaily tDCS sessionsSymptom improvementResting-state functional MRITDCS sessionsNon-invasive neuromodulation interventionsBrain stimulation interventionsFunctional connectivity changesAssociated with connectivityLeft deltoidSymptom dimensionsNeurobiological mechanismsLeft precuneusMode networkPre/postcentral gyri
2019
No evidence of attentional bias toward angry faces in patients with obsessive-compulsive disorder
Skinazi M, de Mathis M, Cohab T, de Marco e Souza M, Shavitt R, Miguel E, Hoexter M, Batistuzzo M. No evidence of attentional bias toward angry faces in patients with obsessive-compulsive disorder. Brazilian Journal Of Psychiatry 2019, 41: 257-260. PMID: 30540026, PMCID: PMC6794136, DOI: 10.1590/1516-4446-2018-0130.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderAttentional biasAngry facesAnxiety disorder patientsOCD patientsDifferent brain activation patternsFunctional neuroimaging protocolsSpecific OCD symptom dimensionsBrain activation patternsSymptom severityOCD symptom dimensionsDisorder patientsAB taskAB paradigmTransdiagnostic approachAB scoresIntelligence testingAnxiety disordersSymptom dimensionsActivation patternsNeuroimaging protocolPsychiatric comorbidityOne-sample t-testFaceDisorders
2017
Randomized, Double-Blind, Placebo-Controlled Trial of N-Acetylcysteine Augmentation for Treatment-Resistant Obsessive-Compulsive Disorder.
Costa DLC, Diniz JB, Requena G, Joaquim MA, Pittenger C, Bloch MH, Miguel EC, Shavitt RG. Randomized, Double-Blind, Placebo-Controlled Trial of N-Acetylcysteine Augmentation for Treatment-Resistant Obsessive-Compulsive Disorder. The Journal Of Clinical Psychiatry 2017, 78: e766-e773. PMID: 28617566, DOI: 10.4088/jcp.16m11101.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAdolescentAdultAgedAnxiety DisordersComorbidityDepressive DisorderDouble-Blind MethodDrug ResistanceDrug Therapy, CombinationFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPsychiatric Status Rating ScalesPsychometricsSelective Serotonin Reuptake InhibitorsYoung AdultConceptsTreatment-resistant obsessive-compulsive disorderObsessive-compulsive disorderY-BOCS scoresN-acetylcysteineNAC groupYale-Brown Obsessive Compulsive Scale scoresTreatment-resistant OCD patientsBaseline Y-BOCS scoresTreatment-Resistant ObsessivePrimary outcome measureAnxiety symptomsDSM-IV criteriaSymptom dimensionsCompulsive Scale scoresSpecific OCD symptom dimensionsOCD symptom dimensionsAntioxidant medicationsAbdominal painPlacebo groupGlutamate modulatorsSecondary outcomesTertiary hospitalOutpatient clinicSeverity scoreWeek 16
2013
Symptom dimensions are associated with age of onset and clinical course of obsessive–compulsive disorder
Kichuk SA, Torres AR, Fontenelle LF, Rosário MC, Shavitt RG, Miguel EC, Pittenger C, Bloch MH. Symptom dimensions are associated with age of onset and clinical course of obsessive–compulsive disorder. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2013, 44: 233-239. PMID: 23410525, PMCID: PMC3654083, DOI: 10.1016/j.pnpbp.2013.02.003.Peer-Reviewed Original ResearchConceptsAge of onsetClinical courseObsessive-compulsive disorderPrimary symptom dimensionsSymptom dimensionsPrimary OCD symptomsChi-square testEarly ageOCD symptom dimensionsYale-Brown ObsessiveAdult patientsComorbid ticsSignificant symptomsLarge cohortDifferent OCD symptom dimensionsHeterogeneous symptomsSymptomsCompulsive ScaleDimensional Yale-Brown ObsessiveAgeSignificant differencesOCD symptomsOnsetInconsistent results
2010
Comorbid major depression in obsessive-compulsive disorder patients
Quarantini L, Torres A, Sampaio A, Fossaluza V, de Mathis M, do Rosário M, Fontenelle L, Ferrão Y, Cordioli A, Petribu K, Hounie A, Miguel E, Shavitt R, Koenen K. Comorbid major depression in obsessive-compulsive disorder patients. Comprehensive Psychiatry 2010, 52: 386-393. PMID: 21087765, DOI: 10.1016/j.comppsych.2010.09.006.Peer-Reviewed Original ResearchConceptsMajor depressive disorderObsessive-compulsive disorderOCD patientsCurrent major depressive disorderComorbid major depressive disorderLifetime major depressive disorderComprehensive psychiatric evaluationComorbid major depressionSevere general psychopathologyHigher severity scoresObsessive-compulsive disorder patientsSymptom dimensionsOCD symptom dimensionsClinical characteristicsFrequent complicationSeverity scoreDepressive disorderMajor depressionPrevalence ratesPsychiatric evaluationDisorder patientsPatientsGeneral psychopathologyDisordersOCD symptoms
2009
The impact of trauma and post-traumatic stress disorder on the treatment response of patients with obsessive-compulsive disorder
Shavitt R, Valério C, Fossaluza V, da Silva E, Cordeiro Q, Diniz J, Belotto-Silva C, Cordioli A, Mari J, Miguel E. The impact of trauma and post-traumatic stress disorder on the treatment response of patients with obsessive-compulsive disorder. European Archives Of Psychiatry And Clinical Neuroscience 2009, 260: 91-99. PMID: 20077119, DOI: 10.1007/s00406-009-0015-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAnxietyDepressionDiagnostic and Statistical Manual of Mental DisordersFemaleFollow-Up StudiesHumansMaleMiddle AgedObsessive-Compulsive DisorderPsychiatric Status Rating ScalesSelective Serotonin Reuptake InhibitorsStatistics, NonparametricStress Disorders, Post-TraumaticTreatment OutcomeConceptsHistory of traumaPost-traumatic stress disorderObsessive-compulsive disorderTreatment responseHT groupBeck Depression InventoryPTSD groupBeck Anxiety InventorySpecific OCD symptom dimensionsConventional treatmentOCD symptom dimensionsOCD patientsSelective serotonin reuptake inhibitorsStress disorderFull DSM-IV criteriaFirst-line treatmentSerotonin reuptake inhibitorsCase series studyPoor treatment responseResistant OCD patientsSymptom dimensionsGreater treatment responseDSM-IV criteriaGreater reductionGroup cognitive behavioral therapy