2021
Toward a neurocircuit-based taxonomy to guide treatment of obsessive–compulsive disorder
Shephard E, Stern E, van den Heuvel O, Costa D, Batistuzzo M, Godoy P, Lopes A, Brunoni A, Hoexter M, Shavitt R, Reddy Y, Lochner C, Stein D, Simpson H, Miguel E. Toward a neurocircuit-based taxonomy to guide treatment of obsessive–compulsive disorder. Molecular Psychiatry 2021, 26: 4583-4604. PMID: 33414496, PMCID: PMC8260628, DOI: 10.1038/s41380-020-01007-8.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderCognitive neuroscienceNeurobiological alterationsMental health researchClinical profileFuture researchCase vignettesPsychiatric symptomsNeuromodulatory treatmentDifferent clinical profilesNeuroscienceEffective treatmentDisordersResearchBehavioralVignettesFindingsHealth researchTreatmentDysfunctionSymptomsPhenotypic expressionImportant limitationsTaxonomyPatients
2017
A General Psychopathology Factor (P Factor) in Children: Structural Model Analysis and External Validation Through Familial Risk and Child Global Executive Function
Martel M, Pan P, Hoffmann M, Gadelha A, do Rosário M, Mari J, Manfro G, Miguel E, Paus T, Bressan R, Rohde L, Salum G. A General Psychopathology Factor (P Factor) in Children: Structural Model Analysis and External Validation Through Familial Risk and Child Global Executive Function. Journal Of Psychopathology And Clinical Science 2017, 126: 137-148. PMID: 27748619, DOI: 10.1037/abn0000205.Peer-Reviewed Original ResearchConceptsChildren's executive functionExecutive functionGlobal executive functionGeneral p factorLittle residual varianceConfirmatory factor analysisChildren ages 6Specific factorsGeneral psychopathology factorFamily riskChild psychopathologyCommunity sampleDisorder diagnostic criteriaMental health researchParental factorsGeneral psychopathologyBest fitting modelPsychopathologyPsychopathology factorAge 6P-factorExternal validityFactor analysisStructured interviewsMental disorders