2024
Perinatal and neonatal factors and mental disorders in children and adolescents: looking for the contributions of the early environment to common and dissociable aspects of psychopathology
Leusin F, Damiano R, Mendes L, Hoffmann M, Manfro A, Pan P, Gadelha A, de Jesus Mari J, Manfro G, Miguel E, Rohde L, Bressan R, Salum G. Perinatal and neonatal factors and mental disorders in children and adolescents: looking for the contributions of the early environment to common and dissociable aspects of psychopathology. European Child & Adolescent Psychiatry 2024, 33: 3571-3581. PMID: 38519607, DOI: 10.1007/s00787-024-02402-0.Peer-Reviewed Original ResearchMental disordersPsychiatric disordersCo-occurrence of mental disordersPresence of mental disordersDomains of psychopathologyYears of age childrenModel psychiatric disordersPsychiatric disorder diagnosisOverall psychopathologyBifactor modelDisorder diagnosisPsychopathologyBehavioral assessmentP-factorEarly environmentLow level of maternal educationLevel of maternal educationLow socioeconomic statusDisordersNeonatal factorsPrimary caregiversAge childrenAssociated with male sexSocioeconomic statusMaternal educationThe S20 Brazilian Mental Health Report for Building a Just World and a Sustainable Planet: Part II.
Mari J, Kapczinski F, Brunoni A, Gadelha A, Baldez D, Miguel E, Scorza F, Caye A, Quagliato L, De Boni R, Salum G, Nardi A. The S20 Brazilian Mental Health Report for Building a Just World and a Sustainable Planet: Part II. Brazilian Journal Of Psychiatry 2024, 46 PMID: 38875470, PMCID: PMC11559842, DOI: 10.47626/1516-4446-2024-3707.Peer-Reviewed Original ResearchMental health reportsHealth reportsHuman rightsMental healthMental disordersMental health careMental health policyMental health systemMental health challengesHealth Working GroupMental healthcareHealth policyHealth systemMental illnessHealth careDigital healthPhysical needsHealth challengesGeneral HospitalPsychiatric patientsInterventional psychiatryRightsTreatment settingsHealthPost-pandemic world
2023
W27. POLYGENIC RISK SCORE AND HOUSEHOLD DEPRIVATION ARE RELATED TO INTERNALIZING SYMPTOMS IN YOUTH
Belangero S, De Oliveira A, Carvalho C, Ota V, Bugiga A, Pan P, Mauer J, Mari J, Santoro M, Miguel E, Hoffmann M, Salum G. W27. POLYGENIC RISK SCORE AND HOUSEHOLD DEPRIVATION ARE RELATED TO INTERNALIZING SYMPTOMS IN YOUTH. European Neuropsychopharmacology 2023, 75: s118-s119. DOI: 10.1016/j.euroneuro.2023.08.217.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsLinear mixed modelsMental disordersHigh Risk Cohort StudyInternalizing symptomsWell-Being AssessmentPotential biological markersParent reportGenome-wide association studiesSelf-report measuresTraumatic eventsCohort studyHigh prevalenceRisk scoreGene-environment interactionsPsychiatric disordersInternalizing psychopathologySignificant associationSymptomsBiological markersUnderlying causeHousehold deprivationScore studyInternalizing problemsEarly life
2022
Utilisation and costs of mental health-related service use among adolescents
Ziebold C, Silva-Ribeiro W, King D, McDaid D, Hoffmann M, Romeo R, Pan P, Miguel E, Bressan R, Rohde L, Salum G, de Jesus Mari J, Evans-Lacko S. Utilisation and costs of mental health-related service use among adolescents. PLOS ONE 2022, 17: e0273628. PMID: 36084089, PMCID: PMC9462733, DOI: 10.1371/journal.pone.0273628.Peer-Reviewed Original ResearchConceptsService useMental illnessParental stigmaSocial care service useTrajectories of psychopathologyCare service useProspective community cohortMental health conditionsMental health problemsMiddle-income countriesAverage annual costService utilisationCommunity cohortHigher oddsPsychiatric disordersCare needsWhite ethnicityMental health-related service useHealth problemsStigmatising attitudesPsychiatric conditionsMental disordersLogistic regressionHealth conditionsMental health
2021
Mental health conditions in Lesbian, Gay, Bisexual, Transgender, Queer and Asexual youth in Brazil: A call for action
Terra T, Schafer J, Pan P, Costa A, Caye A, Gadelha A, Miguel E, Bressan R, Rohde L, Salum G. Mental health conditions in Lesbian, Gay, Bisexual, Transgender, Queer and Asexual youth in Brazil: A call for action. Journal Of Affective Disorders 2021, 298: 190-193. PMID: 34715179, DOI: 10.1016/j.jad.2021.10.108.Peer-Reviewed Original ResearchConceptsAsexual youthMental disordersWell-Being Behavior AssessmentHigh-risk cohortMental health conditionsPost-traumatic stress disorderAttention deficit hyperactivity disorderMental health problemsDeficit hyperactivity disorderMental health disparitiesStressful life eventsDepressive disorderPsychiatric disordersPrevalence estimatesHealth problemsConfidential questionnaireHealth disparitiesLogistic regressionStress disorderAnxiety disordersHealth conditionsConduct disorderGroup comparisonsHyperactivity disorderDisordersPredictors of gaming disorder in children and adolescents: a school-based study
Ferreira F, Bambini B, Tonsig G, Fonseca L, Picon F, Pan P, Salum G, Jackowski A, Miguel E, Rohde L, Bressan R, Gadelha A. Predictors of gaming disorder in children and adolescents: a school-based study. Brazilian Journal Of Psychiatry 2021, 43: 289-292. PMID: 32756806, PMCID: PMC8136393, DOI: 10.1590/1516-4446-2020-0964.Peer-Reviewed Original ResearchConceptsMental disordersWell-Being Behavior AssessmentHigh-risk cohortLogistic regression modelsSchool-based studyGaming disorderPsychiatric disordersUnhealthy patternsDisorder ratesSchool-based sampleDisordersSignificant predictorsFurther riskBrazilian High-Risk CohortCommunity sampleHigh rateBehavior changeMore hoursRegression modelsChildrenPredictorsAdolescentsHoursBehavior assessmentPattern variablesPsychotic-like Experiences and Common Mental Disorders in Childhood and Adolescence: Bidirectional and Transdiagnostic Associations in a Longitudinal Community-based Study
Giocondo J, Salum G, Gadelha A, Argolo F, Simioni A, Mari J, Miguel E, Bressan R, Rohde L, Pan P. Psychotic-like Experiences and Common Mental Disorders in Childhood and Adolescence: Bidirectional and Transdiagnostic Associations in a Longitudinal Community-based Study. Schizophrenia Bulletin Open 2021, 2: sgab028. DOI: 10.1093/schizbullopen/sgab028.Peer-Reviewed Original ResearchCommon mental disordersComorbid psychiatric disordersRisk of PLEsCommunity-based studyMental disordersPsychiatric disordersPsychotic-like experiencesDepressive disorderLongitudinal community-based studyBidirectional associationsCommon psychiatric disordersSubthreshold psychotic symptomsNon-psychotic disordersSubsequent depressive disordersYear old subjectsPsychotic symptomsOlder subjectsCutoff valueComorbidity analysisClinician ratingsSubstance useDisordersBaseline ADHDDistinct phenotypesRisk
2020
Gene expression changes associated with trajectories of psychopathology in a longitudinal cohort of children and adolescents
Ota V, Santoro M, Spindola L, Pan P, Simabucuro A, Xavier G, Vieira-Fonseca T, Zanardo E, dos Santos F, Schäfer J, Kulikowski L, Galante P, Asprino P, Brietzke E, Grassi-Oliveira R, Rohde L, Miguel E, Gadelha A, Mari J, Bressan R, Salum G, Belangero S. Gene expression changes associated with trajectories of psychopathology in a longitudinal cohort of children and adolescents. Translational Psychiatry 2020, 10: 99. PMID: 32184383, PMCID: PMC7078305, DOI: 10.1038/s41398-020-0772-3.Peer-Reviewed Original ResearchConceptsPsychiatric symptomsMental disordersChild Behavior Checklist total scoresTrajectories of psychopathologyBlood gene expression profilesHigh Risk Cohort StudyGeneral psychiatric symptomsBlood gene expression patternsPsychopathological trajectoriesCohort studyLow-low groupLongitudinal cohortPostmortem brainsGeneral psychopathologySpecific disordersTotal scoreGene expressionCBCL scoresGene expression changesGene expression profilesDisordersSymptoms
2019
Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence?
de Araujo C, Swardfager W, Zugman A, Cogo-Moreira H, Belangero S, Ota V, Spindola L, Hakonarson H, Pellegrino R, Gadelha A, Salum G, Pan P, Mansur R, Hoexter M, Picon F, Sato J, Brietzke E, Grassi-Oliveira R, Rohde L, Miguel E, Bressan R, Jackowski A. Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence? CNS Spectrums 2019, 25: 790-796. PMID: 31845634, DOI: 10.1017/s1092852919001688.Peer-Reviewed Original ResearchConceptsSerum BDNF concentrationsBrain-derived neurotrophic factorBDNF concentrationsBDNF genotypeCortical thicknessPsychiatric disordersSerum brain-derived neurotrophic factor (BDNF) concentrationsBrain-derived neurotrophic factor concentrationSubcortical volumesMental disordersWell-Being Behavior AssessmentBrain structuresBDNF serum concentrationsNeurotrophic factor concentrationsPeripheral blood concentrationsHigh Risk Cohort StudyLate childhoodAdult psychiatric disordersLarge independent samplesCohort studyNeurotrophic factorCortical maturationSerum concentrationsBlood concentrationsMet carriersRelationships between childhood maltreatment, impairment in executive functions and disruptive behavior disorders in a community sample of children
Bernardes E, Manitto A, Miguel E, Pan P, Batistuzzo M, Rohde L, Polanczyk G. Relationships between childhood maltreatment, impairment in executive functions and disruptive behavior disorders in a community sample of children. European Child & Adolescent Psychiatry 2019, 29: 969-978. PMID: 31559500, DOI: 10.1007/s00787-019-01408-3.Peer-Reviewed Original ResearchConceptsDisruptive behavior disordersExecutive functionChildhood maltreatmentCognitive flexibilityEF performanceCommunity sampleBehavior disorderSchool-based sampleCognitive mechanismsCognitive tasksInhibitory controlDisruptive behaviorChild maltreatmentMaltreatmentWorse performanceMental disordersModeratorChildrenImpairmentDisordersIndependent relationshipMemoryFuture studiesAssociationTaskObsessive–compulsive disorder
Stein D, Costa D, Lochner C, Miguel E, Reddy Y, Shavitt R, van den Heuvel O, Simpson H. Obsessive–compulsive disorder. Nature Reviews Disease Primers 2019, 5: 52. PMID: 31371720, PMCID: PMC7370844, DOI: 10.1038/s41572-019-0102-3.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSimilar symptom dimensionsExtent of comorbiditySpecific brain circuitsGroup of conditionsTranslational Neuroscience ApproachCognitive behavioral therapyIntractable symptomsReuptake inhibitorsClinical outcomesChronic conditionsGlobal disabilityEffective treatmentInternational ClassificationGlobal mental healthRelated disordersMental disordersNeuropsychiatric disordersRepetitive stereotyped behaviorsBrain circuitsIndividualized assessmentMental healthNeurobiological mechanismsStatistical ManualHomogenous disorderEffects of the interaction between genetic factors and maltreatment on child and adolescent psychiatric disorders
Carvalho C, Pan P, Ota V, Spindola L, Xavier G, Santoro M, Mazzotti D, Pellegrino R, Hakonarson H, Rohde L, Miguel E, Gadelha A, Bressan R, Belangero S. Effects of the interaction between genetic factors and maltreatment on child and adolescent psychiatric disorders. Psychiatry Research 2019, 273: 575-577. PMID: 30716596, DOI: 10.1016/j.psychres.2019.01.078.Peer-Reviewed Original ResearchConceptsMental disordersSingle nucleotide polymorphismsSchool-based prospective studyAdolescent psychiatric disordersBonferroni multiple comparison correctionChild maltreatmentProspective studyPsychiatric disordersMultiple comparison correctionSignificant associationGenetic factorsDisordersNucleotide polymorphismsPsychopathologyLogistic modelMaltreatmentUse of Mental Health Services by Children With Mental Disorders in Two Major Cities in Brazil
Fatori D, Salum G, Rohde L, Pan P, Bressan R, Evans-Lacko S, Polanczyk G, Miguel E, Graeff-Martins A. Use of Mental Health Services by Children With Mental Disorders in Two Major Cities in Brazil. Psychiatric Services 2019, 70: 337-341. PMID: 30651056, DOI: 10.1176/appi.ps.201800389.Peer-Reviewed Original ResearchConceptsMental health servicesMental disordersUnmet needHealth servicesHigh Risk Cohort StudyCombination of psychotherapyMental health treatmentChildren ages 6Cohort studyHealth treatmentCommunity studyAge 6DisordersHealth careLifetime useWhite childrenChildrenHigh rateTreatmentCurrent studyPorto AlegreSao PauloMedicationsPsychotherapyDiagnosis
2018
Diagnostic operationalization and phenomenological heterogeneity in psychiatry: the case of attention deficit hyperactivity disorder
Salum G, Gadelha A, Polanczyk G, Miguel E, Rohde L. Diagnostic operationalization and phenomenological heterogeneity in psychiatry: the case of attention deficit hyperactivity disorder. Salud Mental 2018, 41: 249-259. DOI: 10.17711/sm.0185-3325.2018.037.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderDeficit hyperactivity disorderHyperactivity disorderPhenomenological heterogeneityADHD symptomsTest-rest reliabilitySymptomatic thresholdSymptomatic scalesPathophysiological heterogeneityPsychiatric disordersPsychiatric diagnosisMental disordersSymptomsDiagnostic operationalizationsADHD diagnosisDisordersCross-Sectional and Longitudinal Associations of Temperament and Mental Disorders in Youth
Hoffmann M, Pan P, Manfro G, de Jesus Mari J, Miguel E, Bressan R, Rohde L, Salum G. Cross-Sectional and Longitudinal Associations of Temperament and Mental Disorders in Youth. Child Psychiatry & Human Development 2018, 50: 374-383. PMID: 30259212, DOI: 10.1007/s10578-018-0846-0.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderDisruptive behavior disordersEffortful controlLongitudinal associationsMental disordersWell-Being Behavior AssessmentEffects of temperamentConfirmatory factor analysisTemperament factorsHyperactivity disorderBifactor modelTemperament QuestionnaireAdjusted longitudinal analysesTemperamentBehavior disorderDistressFactor analysisParental interviewsPhobiaBehavior assessmentLongitudinal analysisYouthDisordersLogistic regression modelsEATQThe economic impact of subthreshold and clinical childhood mental disorders
Fatori D, Salum G, Itria A, Pan P, Alvarenga P, Rohde L, Bressan R, Gadelha A, de Jesus Mari J, do Rosário M, Manfro G, Polanczyk G, Miguel E, Graeff-Martins A. The economic impact of subthreshold and clinical childhood mental disorders. Journal Of Mental Health 2018, 27: 588-594. PMID: 29708045, DOI: 10.1080/09638237.2018.1466041.Peer-Reviewed Original ResearchConceptsSubthreshold mental disordersClinical mental disordersMental disordersHigh Risk Cohort StudyCommon health problemLifetime cost estimatesChild mental disordersChildhood mental disordersWell-Being AssessmentSocial service useCohort studyYear old childrenService useEconomic burdenCost-effective programsHealth problemsBrazilian childrenCommunity studyMental healthOlder childrenDisordersDisorder assessmentSerious impairmentMajor Brazilian citiesChildrenF168. PSYCHOTIC EXPERIENCE AND ADOLESCENT BRAIN TRAJECTORY: EVIDENCE FOR STRUCTURAL ALTERATIONS IN DOPAMINERGIC REGIONS
Zugman A, Gadelha A, Argolo F, Pan P, Rohde L, Miguel E, Bressan R, Jackowski A. F168. PSYCHOTIC EXPERIENCE AND ADOLESCENT BRAIN TRAJECTORY: EVIDENCE FOR STRUCTURAL ALTERATIONS IN DOPAMINERGIC REGIONS. Schizophrenia Bulletin 2018, 44: s286-s286. PMCID: PMC5888229, DOI: 10.1093/schbul/sby017.699.Peer-Reviewed Original ResearchCortical thickness measuresMental disordersCortical thicknessPsychotic experiencesSubcortical volumesLower subcortical volumesHigh-risk cohortCurrent psychiatric diagnosisPathogenesis of schizophreniaCurrent psychotic disorderAge interaction termMultiple comparisonsMulti-site longitudinal studyCommunity cohortDopaminergic neurotransmissionSubsequent riskDopaminergic imbalanceRight putamenBrain developmental trajectoriesMRI scansPsychiatric diagnosisPsychotic disordersBaseline assessmentCaudateAdolescent brain
2017
The specific and combined role of domestic violence and mental health disorders during pregnancy on new-born health
Ferraro A, Rohde L, Polanczyk G, Argeu A, Miguel E, Grisi S, Fleitlich-Bilyk B. The specific and combined role of domestic violence and mental health disorders during pregnancy on new-born health. BMC Pregnancy And Childbirth 2017, 17: 257. PMID: 28764678, PMCID: PMC5540537, DOI: 10.1186/s12884-017-1438-x.Peer-Reviewed Original ResearchConceptsPsychosocial factorsMental disordersBirth outcomesObsessive-compulsive disorderMental healthNutritional statusInadequate weight gainMaternal risk behaviorsInadequate prenatal careWeeks of gestationMothers' mental healthPoor nutritional statusCertain risk factorsPublic health priorityMental health disordersSexual domestic violenceCombination of anxietyAnti-social personality disorderPreterm deliveryNeonate outcomesBirth lengthGestational agePregnant womenPrenatal careRisk factorsAssociation between abnormal brain functional connectivity in children and psychopathology: A study based on graph theory and machine learning
Sato J, Biazoli C, Salum G, Gadelha A, Crossley N, Vieira G, Zugman A, Picon F, Pan P, Hoexter M, Amaro E, Anés M, Moura L, Del’Aquilla M, Mcguire P, Rohde L, Miguel E, Jackowski A, Bressan R. Association between abnormal brain functional connectivity in children and psychopathology: A study based on graph theory and machine learning. The World Journal Of Biological Psychiatry 2017, 19: 119-129. PMID: 28635541, DOI: 10.1080/15622975.2016.1274050.Peer-Reviewed Original ResearchConceptsBilateral posterior temporal corticesAbnormal brain functional connectivityMental health disordersBilateral posterior cingulateBrain networksBrain functional connectivityResting-state fMRI dataPosterior temporal cortexBrain network organizationLevels of psychopathologyTemporal cortexHealth disordersTemporal polePosterior cingulateMental disordersBrain developmentFunctional connectivityBrain connectivitySignificant decreaseDisordersGraph theory measuresIndividual brain networksBiological measuresPsychopathologySubjectsA General Psychopathology Factor (P Factor) in Children: Structural Model Analysis and External Validation Through Familial Risk and Child Global Executive Function
Martel M, Pan P, Hoffmann M, Gadelha A, do Rosário M, Mari J, Manfro G, Miguel E, Paus T, Bressan R, Rohde L, Salum G. A General Psychopathology Factor (P Factor) in Children: Structural Model Analysis and External Validation Through Familial Risk and Child Global Executive Function. Journal Of Psychopathology And Clinical Science 2017, 126: 137-148. PMID: 27748619, DOI: 10.1037/abn0000205.Peer-Reviewed Original ResearchConceptsChildren's executive functionExecutive functionGlobal executive functionGeneral p factorLittle residual varianceConfirmatory factor analysisChildren ages 6Specific factorsGeneral psychopathology factorFamily riskChild psychopathologyCommunity sampleDisorder diagnostic criteriaMental health researchParental factorsGeneral psychopathologyBest fitting modelPsychopathologyPsychopathology factorAge 6P-factorExternal validityFactor analysisStructured interviewsMental disorders