2024
Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure
Vriend C, de Joode N, Pouwels P, Liu F, Otaduy M, Pastorello B, Robertson F, Ipser J, Lee S, Hezel D, van Meter P, Batistuzzo M, Hoexter M, Sheshachala K, Narayanaswamy J, Venkatasubramanian G, Lochner C, Miguel E, Reddy Y, Shavitt R, Stein D, Wall M, Simpson H, van den Heuvel O. Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure. Molecular Psychiatry 2024, 29: 1033-1045. PMID: 38228890, PMCID: PMC11176057, DOI: 10.1038/s41380-023-02390-8.Peer-Reviewed Original ResearchObsessive-compulsive disorderPathophysiology of obsessive-compulsive disorderObsessive-compulsive disorder groupAge of OCD onsetOCD onsetHealthy controlsMedication-free adultsWhite matter microstructural alterationsVisual attention processesWhite matter microstructureStructural brain networksStructural connectome analysisWhite matter tractsBayesian multilevel analysisDirection of effectAttentional processesOCD individualsBrain signaturesBrain networksDiffusion MRI studiesPost hoc analysisSagittal stratumConnectome analysisMultilevel analysisStructural connectome
2020
Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative
Simpson H, van den Heuvel O, Miguel E, Reddy Y, Stein D, Lewis-Fernández R, Shavitt R, Lochner C, Pouwels P, Narayanawamy J, Venkatasubramanian G, Hezel D, Vriend C, Batistuzzo M, Hoexter M, de Joode N, Costa D, de Mathis M, Sheshachala K, Narayan M, van Balkom A, Batelaan N, Venkataram S, Cherian A, Marincowitz C, Pannekoek N, Stovezky Y, Mare K, Liu F, Otaduy M, Pastorello B, Rao R, Katechis M, Van Meter P, Wall M. Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative. BMC Psychiatry 2020, 20: 68. PMID: 32059696, PMCID: PMC7023814, DOI: 10.1186/s12888-020-2439-2.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingCircuit abnormalitiesNew global initiativesBrain signaturesGlobal InitiativeHealthy control subjectsMedication-free adultsMultiple brain circuitsMedication-free subjectsBackgroundObsessive–compulsive disorderClinical profileClinical symptomsControl subjectsClinical evaluationHealthy controlsLeading causeGlobal disabilityLifetime prevalenceResonance imagingNeurocognitive assessmentBrain circuitsImaging signaturesFunctional connectivityBrain-behavior associationsDisease dimensions