Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence?
de Araujo C, Swardfager W, Zugman A, Cogo-Moreira H, Belangero S, Ota V, Spindola L, Hakonarson H, Pellegrino R, Gadelha A, Salum G, Pan P, Mansur R, Hoexter M, Picon F, Sato J, Brietzke E, Grassi-Oliveira R, Rohde L, Miguel E, Bressan R, Jackowski A. Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence? CNS Spectrums 2019, 25: 790-796. PMID: 31845634, DOI: 10.1017/s1092852919001688.Peer-Reviewed Original ResearchConceptsSerum BDNF concentrationsBrain-derived neurotrophic factorBDNF concentrationsBDNF genotypeCortical thicknessPsychiatric disordersSerum brain-derived neurotrophic factor (BDNF) concentrationsBrain-derived neurotrophic factor concentrationSubcortical volumesMental disordersWell-Being Behavior AssessmentBrain structuresBDNF serum concentrationsNeurotrophic factor concentrationsPeripheral blood concentrationsHigh Risk Cohort StudyLate childhoodAdult psychiatric disordersLarge independent samplesCohort studyNeurotrophic factorCortical maturationSerum concentrationsBlood concentrationsMet carriersAssociation Between Fractional Amplitude of Low-Frequency Spontaneous Fluctuation and Degree Centrality in Children and Adolescents
Sato J, Biazoli C, Moura L, Crossley N, Zugman A, Picon F, Hoexter M, Amaro E, Miguel E, Rohde L, Bressan R, Jackowski A. Association Between Fractional Amplitude of Low-Frequency Spontaneous Fluctuation and Degree Centrality in Children and Adolescents. Brain Connectivity 2019, 9: 379-387. PMID: 30880423, DOI: 10.1089/brain.2018.0628.Peer-Reviewed Original ResearchConceptsFractional amplitudeBrain functional changesPosterior cingulate/precuneusLateral parietal cortexParietal cortexNeurodevelopmental studiesFunctional changesLow-frequency fluctuationsBOLD signalClinical populationsLarge independent samplesSpontaneous fluctuationsIntra-subject correlationNeurophysiological correlatesGroup levelIndependent samples