2020
Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative
Simpson H, van den Heuvel O, Miguel E, Reddy Y, Stein D, Lewis-Fernández R, Shavitt R, Lochner C, Pouwels P, Narayanawamy J, Venkatasubramanian G, Hezel D, Vriend C, Batistuzzo M, Hoexter M, de Joode N, Costa D, de Mathis M, Sheshachala K, Narayan M, van Balkom A, Batelaan N, Venkataram S, Cherian A, Marincowitz C, Pannekoek N, Stovezky Y, Mare K, Liu F, Otaduy M, Pastorello B, Rao R, Katechis M, Van Meter P, Wall M. Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative. BMC Psychiatry 2020, 20: 68. PMID: 32059696, PMCID: PMC7023814, DOI: 10.1186/s12888-020-2439-2.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingCircuit abnormalitiesNew global initiativesBrain signaturesGlobal InitiativeHealthy control subjectsMedication-free adultsMultiple brain circuitsMedication-free subjectsBackgroundObsessive–compulsive disorderClinical profileClinical symptomsControl subjectsClinical evaluationHealthy controlsLeading causeGlobal disabilityLifetime prevalenceResonance imagingNeurocognitive assessmentBrain circuitsImaging signaturesFunctional connectivityBrain-behavior associationsDisease dimensions
2000
A voxel-based investigation of regional cerebral blood flow abnormalities in obsessive–compulsive disorder using single photon emission computed tomography (SPECT)
Busatto G, Zamignani D, Buchpiguel C, Garrido G, Glabus M, Rocha E, Maia A, Rosario-Campos M, Castro C, Furuie S, Gutierrez M, McGuire P, Miguel E. A voxel-based investigation of regional cerebral blood flow abnormalities in obsessive–compulsive disorder using single photon emission computed tomography (SPECT). Psychiatry Research 2000, 99: 15-27. PMID: 10891646, DOI: 10.1016/s0925-4927(00)00050-0.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexECD uptakeObsessive-compulsive disorderCingulate cortexLateral orbitofrontal cortexObsessive-compulsive symptomsOrbitofrontal cortexControl subjectsOCD patientsLeft dorsal anterior cingulate cortexRegional cerebral blood flow abnormalitiesImaging studiesCerebral blood flow abnormalitiesRight medial orbitofrontal cortexPatient samplesRegional cerebral blood flowPathophysiology of OCDRight lateral orbitofrontal cortexRCBF SPECT studiesHealthy control subjectsBlood flow abnormalitiesCerebral blood flowLarger patient samplesSmall patient sampleLeft lateral orbitofrontal cortex