2019
Caudate volume differences among treatment responders, non-responders and controls in children with obsessive–compulsive disorder
Vattimo E, Barros V, Requena G, Sato J, Fatori D, Miguel E, Shavitt R, Hoexter M, Batistuzzo M. Caudate volume differences among treatment responders, non-responders and controls in children with obsessive–compulsive disorder. European Child & Adolescent Psychiatry 2019, 28: 1607-1617. PMID: 30972581, DOI: 10.1007/s00787-019-01320-w.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderGroup cognitive behavioral therapyPediatric obsessive-compulsive disorderRight caudateTreatment responseCognitive behavioral therapyCaudate nucleusPossible neural substrateTreatment respondersGM volumeStructural magnetic resonance imagingNeural substratesPrevious evidenceNeurobiological underpinningsOrbitofrontal cortexAge-matched controlsTotal GM volumeMagnetic resonance imagingBrain structuresResonance imagingChildrenRespondersBonferroni correctionCaudatePatients
2018
Adaptive treatment strategies for children and adolescents with Obsessive-Compulsive Disorder: A sequential multiple assignment randomized trial
Fatori D, de Bragança Pereira CA, Asbahr FR, Requena G, Alvarenga PG, de Mathis MA, Rohde LA, Leckman JF, March JS, Polanczyk GV, Miguel EC, Shavitt RG. Adaptive treatment strategies for children and adolescents with Obsessive-Compulsive Disorder: A sequential multiple assignment randomized trial. Journal Of Anxiety Disorders 2018, 58: 42-50. PMID: 30025255, DOI: 10.1016/j.janxdis.2018.07.002.Peer-Reviewed Original ResearchConceptsGroup cognitive behavioral therapySequential multiple assignmentTreatment failureInitial treatmentBaseline Yale-Brown ObsessiveChildhood OCDEffective initial treatmentProvision of treatmentCompulsive Scale scoresCognitive behavioral therapyAdaptive treatment strategiesYale-Brown ObsessiveSame regimenObsessive-compulsive disorderTreatment strategiesSymptom reductionPrimary analysisScale scoreFluoxetineTime pointsWeeksTreatmentChildrenEffect sizeTrials
2012
CLINICAL PREDICTORS OF LONG‐TERM OUTCOME IN OBSESSIVE‐COMPULSIVE DISORDER
Jakubovski E, Diniz J, Valerio C, Fossaluza V, Belotto‐Silva C, Gorenstein C, Miguel E, Shavitt R. CLINICAL PREDICTORS OF LONG‐TERM OUTCOME IN OBSESSIVE‐COMPULSIVE DISORDER. Depression And Anxiety 2012, 30: 763-772. PMID: 23109056, DOI: 10.1002/da.22013.Peer-Reviewed Original ResearchConceptsLong-term outcomesObsessive-compulsive disorderPositive family historyGroup cognitive behavioral therapyDepressive disorderFamily historyOCD patientsOnset of OCDInitial treatment modalityComorbid psychiatric disordersPercent of subjectsBeck depression scoresDuration of OCDCognitive behavioral therapyYale-Brown ObsessiveUntreated patientsClinical factorsClinical predictorsInitial treatmentOpen trialWorse prognosisClinical variablesPharmacological treatmentPsychiatric comorbidityTreatment modalities
2011
Group cognitive-behavioral therapy versus selective serotonin reuptake inhibitors for obsessive-compulsive disorder: A practical clinical trial
Belotto-Silva C, Diniz J, Malavazzi D, Valério C, Fossaluza V, Borcato S, Seixas A, Morelli D, Miguel E, Shavitt R. Group cognitive-behavioral therapy versus selective serotonin reuptake inhibitors for obsessive-compulsive disorder: A practical clinical trial. Journal Of Anxiety Disorders 2011, 26: 25-31. PMID: 21907540, DOI: 10.1016/j.janxdis.2011.08.008.Peer-Reviewed Original ResearchConceptsGroup cognitive behavioral therapyY-BOCS scoresPsychiatric comorbidityCognitive behavioral therapySSRI groupMean Y-BOCS scoreSelective serotonin reuptake inhibitorsBaseline Y-BOCS scoresY-BOCS reductionSerotonin reuptake inhibitorsMore psychiatric comorbiditiesPractical clinical trialsReal-world populationObsessive-compulsive disorder outpatientsBroad inclusion criteriaAdditional psychiatric comorbidityReuptake inhibitorsObsessive-compulsive disorderClinical effectivenessClinical trialsMajor depressionCGI ratingsInclusion criteriaComorbiditiesWorse response
2009
The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description
Hoexter M, Shavitt R, D'Alcante C, Cecconi J, Diniz J, Belotto-Silva C, Hounie A, Borcato S, Moraes I, Joaquim M, Cappi C, Sampaio A, de Mathis M, Batistuzzo M, Lopes A, Rosa A, Muniz R, Marques A, Santos L, Taub A, de Souza Duran F, Dougherty D, Busatto G, Bressan R, Miguel E. The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description. Brazilian Journal Of Psychiatry 2009, 31: 349-353. PMID: 20098825, DOI: 10.1590/s1516-44462009000400011.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorder patientsObsessive-compulsive disorderNeuropsychological evaluationClinical trialsGroup cognitive behavioral therapyDisorder patientsTRODAT-1 single photon emissionIntegrative neurobiological modelCognitive behavioral therapySelective serotonin reuptake inhibitorsAdult obsessive-compulsive disorder (OCD) patientsMagnetic resonance imagesDrug-naïve OCD patientsDrug-naïve patientsSerotonin reuptake inhibitorsSame research procedureNeurobiological modelsSingle photon emissionResonance imagesTreatment response studiesOCD patientsReuptake inhibitorsHealthy controlsBlood samplesPatientsThe impact of trauma and post-traumatic stress disorder on the treatment response of patients with obsessive-compulsive disorder
Shavitt R, Valério C, Fossaluza V, da Silva E, Cordeiro Q, Diniz J, Belotto-Silva C, Cordioli A, Mari J, Miguel E. The impact of trauma and post-traumatic stress disorder on the treatment response of patients with obsessive-compulsive disorder. European Archives Of Psychiatry And Clinical Neuroscience 2009, 260: 91-99. PMID: 20077119, DOI: 10.1007/s00406-009-0015-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAnxietyDepressionDiagnostic and Statistical Manual of Mental DisordersFemaleFollow-Up StudiesHumansMaleMiddle AgedObsessive-Compulsive DisorderPsychiatric Status Rating ScalesSelective Serotonin Reuptake InhibitorsStatistics, NonparametricStress Disorders, Post-TraumaticTreatment OutcomeConceptsHistory of traumaPost-traumatic stress disorderObsessive-compulsive disorderTreatment responseHT groupBeck Depression InventoryPTSD groupBeck Anxiety InventorySpecific OCD symptom dimensionsConventional treatmentOCD symptom dimensionsOCD patientsSelective serotonin reuptake inhibitorsStress disorderFull DSM-IV criteriaFirst-line treatmentSerotonin reuptake inhibitorsCase series studyPoor treatment responseResistant OCD patientsSymptom dimensionsGreater treatment responseDSM-IV criteriaGreater reductionGroup cognitive behavioral therapy