2023
W27. POLYGENIC RISK SCORE AND HOUSEHOLD DEPRIVATION ARE RELATED TO INTERNALIZING SYMPTOMS IN YOUTH
Belangero S, De Oliveira A, Carvalho C, Ota V, Bugiga A, Pan P, Mauer J, Mari J, Santoro M, Miguel E, Hoffmann M, Salum G. W27. POLYGENIC RISK SCORE AND HOUSEHOLD DEPRIVATION ARE RELATED TO INTERNALIZING SYMPTOMS IN YOUTH. European Neuropsychopharmacology 2023, 75: s118-s119. DOI: 10.1016/j.euroneuro.2023.08.217.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsLinear mixed modelsMental disordersHigh Risk Cohort StudyInternalizing symptomsWell-Being AssessmentPotential biological markersParent reportGenome-wide association studiesSelf-report measuresTraumatic eventsCohort studyHigh prevalenceRisk scoreGene-environment interactionsPsychiatric disordersInternalizing psychopathologySignificant associationSymptomsBiological markersUnderlying causeHousehold deprivationScore studyInternalizing problemsEarly life
2020
Cutting-edge genetics in obsessive-compulsive disorder
Saraiva L, Cappi C, Simpson H, Stein D, Viswanath B, van den Heuvel O, Reddy Y, Miguel E, Shavitt R. Cutting-edge genetics in obsessive-compulsive disorder. Faculty Reviews 2020, 9: 30. PMID: 33659962, PMCID: PMC7886082, DOI: 10.12703/r/9-30.Peer-Reviewed Original ResearchGenetic architectureWide association studyNumber variation studiesCutting-edge geneticsWhole-exome sequencing studiesUnderlying biological pathwaysHuman cell modelsGene networksStudy of endophenotypesGene expressionBiological pathwaysSequencing studiesAssociation studiesAnimal systemsGeneticsGene-environment interactionsCell modelBiological basisPolygenic risk scoresEvidence pointsSynaptic transmissionRecent advancesVariation studiesExperimental animal systemsNeuropsychiatric disorders