2023
Gamma knife capsulotomy for intractable OCD: Neuroimage analysis of lesion size, location, and clinical response
McLaughlin N, Magnotti J, Banks G, Nanda P, Hoexter M, Lopes A, Batistuzzo M, Asaad W, Stewart C, Paulo D, Noren G, Greenberg B, Malloy P, Salloway S, Correia S, Pathak Y, Sheehan J, Marsland R, Gorgulho A, De Salles A, Miguel E, Rasmussen S, Sheth S. Gamma knife capsulotomy for intractable OCD: Neuroimage analysis of lesion size, location, and clinical response. Translational Psychiatry 2023, 13: 134. PMID: 37185805, PMCID: PMC10130137, DOI: 10.1038/s41398-023-02425-2.Peer-Reviewed Original ResearchConceptsY-BOCS reductionObsessive-compulsive disorderGamma knife capsulotomyLesion sizeRefractory obsessive-compulsive disorderOverall lesion volumeIntractable obsessive-compulsive disorderLesion-symptom mappingVoxel-wise lesion-symptom mappingClinical improvementClinical responseWhite matter pathwaysClinical outcomesFull respondersConventional therapyInternal capsuleLesion characteristicsLesion volumeAnterior limbEffective treatmentLesion locationLesion occurrenceCoronal planeSize/locationPatients
2009
Neuropsychological Outcome of Ventral CapsularVentral Striatal Gamma Capsulotomy for Refractory Obsessive-Compulsive Disorder: A Pilot Study
Taub A, Lopes A, Fuentes D, D'Alcante C, de Mathis M, Canteras M, Siviero M, Greenberg B, Norén G, Batistuzzo M, Hoexter M, Cecílio S, Savage C, Rasmussen S, Miguel E. Neuropsychological Outcome of Ventral CapsularVentral Striatal Gamma Capsulotomy for Refractory Obsessive-Compulsive Disorder: A Pilot Study. Journal Of Neuropsychiatry 2009, 21: 393-397. PMID: 19996247, DOI: 10.1176/jnp.2009.21.4.393.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderObsessive-compulsive patientsProfound cognitive deficitsAbstract reasoningNeuropsychological batteryRefractory obsessive-compulsive disorderCognitive deficitsNeuropsychological outcomesGamma knife capsulotomyMemoryVocabularyPilot studyDeficitsReasoningLearningDisordersAttentionBatteries