2005
A family study of early‐onset obsessive‐compulsive disorder
do Rosario‐Campos M, Leckman JF, Curi M, Quatrano S, Katsovitch L, Miguel EC, Pauls DL. A family study of early‐onset obsessive‐compulsive disorder. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2005, 136B: 92-97. PMID: 15892140, DOI: 10.1002/ajmg.b.30149.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRecurrence riskChronic ticsFirst-degree family membersChildhood-onset obsessive-compulsive disorderDiagnosis of OCDChronic tic disorderStandardized semi-structured interviewFirst-degree relativesEarly-onset casesOnset obsessive-compulsive disorderDSM-IV criteriaEarly-onset obsessive-compulsive disorderBest-estimate processRandom digit dialingHigh comorbid ratesAge of onsetFamily studiesHigh genetic loadingMean ageSpecialty clinicTic disordersComorbid ratesValid subgroupsCase relatives
2001
Regional Cerebral Blood Flow Abnormalities in Early-Onset Obsessive-Compulsive Disorder: An Exploratory SPECT Study
BUSATTO G, BUCHPIGUEL C, ZAMIGNANI D, GARRIDO G, GLABUS M, ROSARIO-CAMPOS M, CASTRO C, MAIA A, ROCHA E, MCGUIRE P, MIGUEL E. Regional Cerebral Blood Flow Abnormalities in Early-Onset Obsessive-Compulsive Disorder: An Exploratory SPECT Study. Journal Of The American Academy Of Child & Adolescent Psychiatry 2001, 40: 347-354. PMID: 11288777, DOI: 10.1097/00004583-200103000-00015.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderLate-onset subjectsOCD subjectsRegional cerebral blood flow (rCBF) single-photon emissionCerebral blood flow single photon emissionRegional cerebral blood flow abnormalitiesCerebral blood flow abnormalitiesObsessive-compulsive symptomsPathophysiology of OCDBlood flow abnormalitiesEarly-onset casesOnset obsessive-compulsive disorderFrontal-subcortical circuitsAge of onsetEarly-onset subjectsAnterior cingulate cortexPrefrontal cortex relativeSingle photon emissionStatistical parametric mappingRCBF differencesRight thalamusHealthy controlsFlow abnormalitiesClinical dataCortex relative