2015
Reduced Prefrontal Activation in Pediatric Patients With Obsessive-Compulsive Disorder During Verbal Episodic Memory Encoding
Batistuzzo M, Balardin J, da Graça Morais Martin M, Hoexter M, Bernardes E, Borcato S, de Marco e Souza M, Querido C, Morais R, de Alvarenga P, Lopes A, Shavitt R, Savage C, Amaro E, Miguel E, Polanczyk G, Miotto E. Reduced Prefrontal Activation in Pediatric Patients With Obsessive-Compulsive Disorder During Verbal Episodic Memory Encoding. Journal Of The American Academy Of Child & Adolescent Psychiatry 2015, 54: 849-858. PMID: 26407495, DOI: 10.1016/j.jaac.2015.06.020.Peer-Reviewed Original ResearchConceptsVerbal episodic memoryObsessive-compulsive disorderEpisodic memoryOrbitofrontal cortexPrefrontal cortexSemantic clusteringFunctional magnetic resonance imagingDorsomedial prefrontal cortexAltered brain activationDifferent neural mechanismsPathophysiology of OCDUnrelated wordsPrefrontal activationBrain activationWord listsExecutive dysfunctionNeural mechanismsTotal wordsCompulsive Scale scoresYale-Brown Obsessive Compulsive Scale scoresStrategy scoresStrategy applicationMemoryCortexKey regionsMulticenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder
de Wit S, Alonso P, Schweren L, Mataix-Cols D, Lochner C, Menchón J, Stein D, Fouche J, Soriano-Mas C, Sato J, Hoexter M, Denys D, Nakamae T, Nishida S, Kwon J, Jang J, Busatto G, Cardoner N, Cath D, Fukui K, Jung W, Kim S, Miguel E, Narumoto J, Phillips M, Pujol J, Remijnse P, Sakai Y, Shin N, Yamada K, Veltman D, van den Heuvel O. Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder. FOCUS The Journal Of Lifelong Learning In Psychiatry 2015, 13: 204-212. DOI: 10.1176/appi.focus.130210.Peer-Reviewed Original ResearchHealthy comparison subjectsObsessive-compulsive disorderOCD patientsHealthy subjectsComparison subjectsMatter volumeGreater cerebellar gray matter volumeStructural T1-weighted MRI scansWhite matter brain volumesWhite matter volume differencesT1-weighted MRI scansWhite matter volumePrevious smaller studiesStructural brain scansGray matter volumeCerebellar gray matter volumeVoxel-based morphometryAdult OCD patientsAnterior cingulate cortexAltered neuroplasticityClinical variablesInferior frontal gyrusCognitive dysfunctionDorsomedial prefrontal cortexMRI scans
2014
Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder
de Wit S, Alonso P, Schweren L, Mataix-Cols D, Lochner C, Menchón J, Stein D, Fouche J, Soriano-Mas C, Sato J, Hoexter M, Denys D, Nakamae T, Nishida S, Kwon J, Jang J, Busatto G, Cardoner N, Cath D, Fukui K, Jung W, Kim S, Miguel E, Narumoto J, Phillips M, Pujol J, Remijnse P, Sakai Y, Shin N, Yamada K, Veltman D, van den Heuvel O. Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder. American Journal Of Psychiatry 2014, 171: 340-349. PMID: 24220667, DOI: 10.1176/appi.ajp.2013.13040574.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsObsessive-compulsive disorderOCD patientsHealthy subjectsComparison subjectsGreater cerebellar gray matter volumeMatter volumeStructural T1-weighted MRI scansWhite matter brain volumesWhite matter volume differencesT1-weighted MRI scansWhite matter volumePrevious smaller studiesStructural brain scansGray matter volumeVoxel-based morphometryAdult OCD patientsCerebellar gray matter volumeAnterior cingulate cortexAltered neuroplasticityClinical variablesInferior frontal gyrusCognitive dysfunctionDorsomedial prefrontal cortexTemporal cortex