2024
F18. ROLE OF PSYCHIATRIC-ASSOCIATED SNVS IN THE EARLY ADULTHOOD: INSIGHTS FROM LONGITUDINAL NEUROIMAGING
Ito L, Ota V, Fernandes D, Martins A, Carvalho C, Zugman A, Sato J, Bressan R, Miguel E, Pan P, Salum G, Belangero S, Santoro M. F18. ROLE OF PSYCHIATRIC-ASSOCIATED SNVS IN THE EARLY ADULTHOOD: INSIGHTS FROM LONGITUDINAL NEUROIMAGING. European Neuropsychopharmacology 2024, 87: 214-215. DOI: 10.1016/j.euroneuro.2024.08.429.Peer-Reviewed Original ResearchPost-traumatic stress disorderAttention deficit/hyperactivity disorderBrain regionsBipolar disorderMental conditionBrain structuresBrazilian High-Risk Cohort StudyPrefrontal cortex regionsFrontal pole regionsHigh Risk Cohort StudyLateral orbitofrontal regionGenome-wide association studiesSignificant main effectDepressive disorderMixed-effects modelsStress disorderDeficit/hyperactivity disorderFrontal cortexOrbitofrontal regionsBiological underpinningsGenetic influencesCortex regionsLongitudinal relationshipIntracranial volumeEarly adulthood
2023
Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents
Honorato-Mauer J, Xavier G, Ota V, Chehimi S, Mafra F, Cuóco C, Ito L, Ormond R, Asprino P, Oliveira A, Bugiga A, Torrecilhas A, Bressan R, Manfro G, Miguel E, Rohde L, Pan P, Salum G, Pellegrino R, Belangero S, Santoro M. Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents. Translational Psychiatry 2023, 13: 47. PMID: 36746925, PMCID: PMC9902559, DOI: 10.1038/s41398-023-02326-4.Peer-Reviewed Original ResearchConceptsMental health disordersCross-sectional analysisMajor depressive disorderAttention-deficit/hyperactivity disorderHealth disordersAnxiety disordersExtracellular vesiclesLarge ongoing cohort studiesMiR-432-5pPeripheral extracellular vesiclesTime pointsOngoing cohort studyMiR-328-3pSerum extracellular vesiclesLongitudinal analysisWave 2Deficit/hyperactivity disorderAdolescent participantsTotal extracellular vesiclesAttention-deficit/hyperactivityMiRNA expressionCohort studyDepressive disorderMajor depressionMiR-584-5p
2021
Mental health conditions in Lesbian, Gay, Bisexual, Transgender, Queer and Asexual youth in Brazil: A call for action
Terra T, Schafer J, Pan P, Costa A, Caye A, Gadelha A, Miguel E, Bressan R, Rohde L, Salum G. Mental health conditions in Lesbian, Gay, Bisexual, Transgender, Queer and Asexual youth in Brazil: A call for action. Journal Of Affective Disorders 2021, 298: 190-193. PMID: 34715179, DOI: 10.1016/j.jad.2021.10.108.Peer-Reviewed Original ResearchConceptsAsexual youthMental disordersWell-Being Behavior AssessmentHigh-risk cohortMental health conditionsPost-traumatic stress disorderAttention deficit hyperactivity disorderMental health problemsDeficit hyperactivity disorderMental health disparitiesStressful life eventsDepressive disorderPsychiatric disordersPrevalence estimatesHealth problemsConfidential questionnaireHealth disparitiesLogistic regressionStress disorderAnxiety disordersHealth conditionsConduct disorderGroup comparisonsHyperactivity disorderDisordersPsychotic-like Experiences and Common Mental Disorders in Childhood and Adolescence: Bidirectional and Transdiagnostic Associations in a Longitudinal Community-based Study
Giocondo J, Salum G, Gadelha A, Argolo F, Simioni A, Mari J, Miguel E, Bressan R, Rohde L, Pan P. Psychotic-like Experiences and Common Mental Disorders in Childhood and Adolescence: Bidirectional and Transdiagnostic Associations in a Longitudinal Community-based Study. Schizophrenia Bulletin Open 2021, 2: sgab028. DOI: 10.1093/schizbullopen/sgab028.Peer-Reviewed Original ResearchCommon mental disordersComorbid psychiatric disordersRisk of PLEsCommunity-based studyMental disordersPsychiatric disordersPsychotic-like experiencesDepressive disorderLongitudinal community-based studyBidirectional associationsCommon psychiatric disordersSubthreshold psychotic symptomsNon-psychotic disordersSubsequent depressive disordersYear old subjectsPsychotic symptomsOlder subjectsCutoff valueComorbidity analysisClinician ratingsSubstance useDisordersBaseline ADHDDistinct phenotypesRisk
2017
Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample
Pan P, Sato J, Salum G, Rohde L, Gadelha A, Zugman A, Mari J, Jackowski A, Picon F, Miguel E, Pine D, Leibenluft E, Bressan R, Stringaris A. Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample. American Journal Of Psychiatry 2017, 174: 1112-1119. PMID: 28946760, PMCID: PMC10752293, DOI: 10.1176/appi.ajp.2017.17040430.Peer-Reviewed Original ResearchConceptsResting-state functional MRIIntrinsic functional connectivityDepressive disorderFunctional connectivityFunctional MRIReward networkFuture depressive disorderAdolescent depressive disordersLeft ventral striatumOnset of depressionBrain reward networksAberrant reward processingAttention deficit hyperactivity disorderDeficit hyperactivity disorderLongitudinal communityChildren 6Ventral striatumAdolescent depressionLogistic regressionHyperactivity disorderSubstance useYouth depressionDisordersDepressionFuture riskComorbidity, age of onset and suicidality in obsessive–compulsive disorder (OCD): An international collaboration
Brakoulias V, Starcevic V, Belloch A, Brown C, Ferrao Y, Fontenelle L, Lochner C, Marazziti D, Matsunaga H, Miguel E, Reddy Y, do Rosario M, Shavitt R, Sundar A, Stein D, Torres A, Viswasam K. Comorbidity, age of onset and suicidality in obsessive–compulsive disorder (OCD): An international collaboration. Comprehensive Psychiatry 2017, 76: 79-86. PMID: 28433854, DOI: 10.1016/j.comppsych.2017.04.002.Peer-Reviewed Original ResearchConceptsAge of onsetObsessive-compulsive disorderMajor depressive disorderComorbid disordersPsychiatric comorbidityAnxiety disordersSpecific phobiaDepressive disorderMajor depressionSuicidal ideationCo-occurring major depressive disorderLifetime psychiatric comorbiditySocial phobiaCurrent comorbid disordersPatterns of comorbidityComorbid major depressionPrimary obsessive-compulsive disorderDisorder treatment centersEarly ageBody dysmorphic disorderAdult patientsObsessive-compulsive personality disorderPsychiatric diagnostic classificationClinical variablesOCD comorbidityGene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder
Spindola L, Pan P, Moretti P, Ota V, Santoro M, Cogo-Moreira H, Gadelha A, Salum G, Manfro G, Mari J, Brentani H, Grassi-Oliveira R, Brietzke E, Miguel E, Rohde L, Sato J, Bressan R, Belangero S. Gene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder. Journal Of Psychiatric Research 2017, 92: 24-30. PMID: 28384542, DOI: 10.1016/j.jpsychires.2017.03.015.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild AbuseCohort StudiesDepressive Disorder, MajorFemaleGene ExpressionGenetic TestingHumansHypothalamo-Hypophyseal SystemInterleukin-1betaMaleModels, BiologicalPeptide FragmentsPituitary-Adrenal SystemReceptors, GlucocorticoidReceptors, Tumor Necrosis Factor, Type IResidence CharacteristicsRNA, MessengerTumor Necrosis Factor-alphaConceptsMajor depressive disorderBlood of childrenDepressive disorderChildhood maltreatmentMDD diagnosisRole of glucocorticoidsWhole blood mRNA levelsCM historyGene expressionAdrenal axisIllness exposureHealthy controlsDepressive symptomsMDD groupLarger studyMRNA expressionMRNA levelsExpression levelsInflammationTNFChildrenDiagnosisBloodAdolescentsNR3C1The Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children
Saad LO, do Rosario MC, Cesar RC, Batistuzzo MC, Hoexter MQ, Manfro GG, Shavitt RG, Leckman JF, Miguel EC, Alvarenga PG. The Child Behavior Checklist—Obsessive-Compulsive Subscale Detects Severe Psychopathology and Behavioral Problems Among School-Aged Children. Journal Of Child And Adolescent Psychopharmacology 2017, 27: 342-348. PMID: 28151703, PMCID: PMC5439443, DOI: 10.1089/cap.2016.0125.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsPsychiatric comorbidityPredictive valueBehavioral problemsDSM-IV psychiatric diagnosesPresence of OCSGroup of patientsHigh-risk cohortSignificant obsessive-compulsive symptomsNegative predictive valuePositive predictive valueHigh rateSeverity of OCSRisk cohortSchool-Aged ChildrenDepressive disorderFunctional impairmentPsychiatric diagnosisChild Behavior ChecklistComorbiditiesSevere psychopathologyBeing AssessmentScreening toolPediatric OCDAnxiety disordersM31 Gene Expression In Blood of Children And Adolescents: Influence of Environmental Stressors On Major Depressive Disorder
Spindola L, Pan P, Moretti P, Ota V, Santoro M, Cogo-Moreira H, Gadelha A, Salum G, Manfro G, Mari J, Brentani H, Grassi-Oliveira R, Brietzke E, Miguel E, Rohde L, Sato J, Bressan R, Belangero S. M31 Gene Expression In Blood of Children And Adolescents: Influence of Environmental Stressors On Major Depressive Disorder. European Neuropsychopharmacology 2017, 27: s387-s388. DOI: 10.1016/j.euroneuro.2016.09.422.Peer-Reviewed Original ResearchMajor depressive disorderBlood of childrenPrenatal alcoholDepressive disorderChildhood maltreatmentMDD diagnosisPt exposureRole of glucocorticoidsPeripheral mRNA expressionGene expressionTobacco exposureIllness exposureHealthy controlsIL1B expressionDepressive symptomsMDD groupLarger studyMRNA expressionWhole bloodDisordersBloodExpression levelsInflammationTNFChildren
2012
CLINICAL PREDICTORS OF LONG‐TERM OUTCOME IN OBSESSIVE‐COMPULSIVE DISORDER
Jakubovski E, Diniz J, Valerio C, Fossaluza V, Belotto‐Silva C, Gorenstein C, Miguel E, Shavitt R. CLINICAL PREDICTORS OF LONG‐TERM OUTCOME IN OBSESSIVE‐COMPULSIVE DISORDER. Depression And Anxiety 2012, 30: 763-772. PMID: 23109056, DOI: 10.1002/da.22013.Peer-Reviewed Original ResearchConceptsLong-term outcomesObsessive-compulsive disorderPositive family historyGroup cognitive behavioral therapyDepressive disorderFamily historyOCD patientsOnset of OCDInitial treatment modalityComorbid psychiatric disordersPercent of subjectsBeck depression scoresDuration of OCDCognitive behavioral therapyYale-Brown ObsessiveUntreated patientsClinical factorsClinical predictorsInitial treatmentOpen trialWorse prognosisClinical variablesPharmacological treatmentPsychiatric comorbidityTreatment modalities
2011
Brazilian psychiatric brain bank: a new contribution tool to network studies
de Oliveira K, Nery F, Ferreti R, Lima M, Cappi C, Machado-Lima A, Polichiso L, Carreira L, Ávila C, Alho A, Brentani H, Miguel E, Heinsen H, Jacob-Filho W, Pasqualucci C, Lafer B, Grinberg L. Brazilian psychiatric brain bank: a new contribution tool to network studies. Cell And Tissue Banking 2011, 13: 315-326. PMID: 21562728, DOI: 10.1007/s10561-011-9258-0.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderBipolar disorderBrain BankBrazilian Aging Brain Study GroupMajor depressive disorderSubstance use disordersMood disorder NOSDepressive disorderStudy groupPsychiatric assessmentDisorder NOSUse disordersAverage ageAutopsy serviceNeuropsychiatric diseasesObsessive-compulsive spectrum symptomsOCD patientsOptimal fixationDisordersCompulsive disorderSpectrum symptomsBrainPsychiatric researchMolecular studiesUrgent needSuicidality in obsessive-compulsive disorder: prevalence and relation to symptom dimensions and comorbid conditions.
Torres A, Ramos-Cerqueira A, Ferrão Y, Fontenelle L, do Rosário M, Miguel E. Suicidality in obsessive-compulsive disorder: prevalence and relation to symptom dimensions and comorbid conditions. The Journal Of Clinical Psychiatry 2011, 72: 17-26; quiz 119-20. PMID: 21272513, DOI: 10.4088/jcp.09m05651blu.Peer-Reviewed Original ResearchMeSH KeywordsAdultComorbidityCross-Sectional StudiesDepressive Disorder, MajorDisruptive, Impulse Control, and Conduct DisordersFemaleHumansLongitudinal StudiesMaleObsessive-Compulsive DisorderPersonality InventoryPrevalenceReligion and PsychologyRisk FactorsSexual BehaviorStress Disorders, Post-TraumaticSuicideSuicide, AttemptedSurveys and QuestionnairesConceptsPosttraumatic stress disorderMajor depressive disorderObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleCurrent suicidal thoughtsSubstance use disordersImpulse control disordersSuicidal thoughtsObsessive Compulsive ScaleDepressive disorderUse disordersDSM-IV Axis I DisordersSuicidal behaviorComorbid substance use disorderCompulsive ScaleOCD patientsLifetime major depressive disorderCross-sectional studyStructured Clinical InterviewAxis I DisordersLogistic regression analysisPrimary obsessive-compulsive disorderSymptom dimensionsLifetime suicidal thoughtsBrazilian Research Consortium
2010
Comorbid major depression in obsessive-compulsive disorder patients
Quarantini L, Torres A, Sampaio A, Fossaluza V, de Mathis M, do Rosário M, Fontenelle L, Ferrão Y, Cordioli A, Petribu K, Hounie A, Miguel E, Shavitt R, Koenen K. Comorbid major depression in obsessive-compulsive disorder patients. Comprehensive Psychiatry 2010, 52: 386-393. PMID: 21087765, DOI: 10.1016/j.comppsych.2010.09.006.Peer-Reviewed Original ResearchConceptsMajor depressive disorderObsessive-compulsive disorderOCD patientsCurrent major depressive disorderComorbid major depressive disorderLifetime major depressive disorderComprehensive psychiatric evaluationComorbid major depressionSevere general psychopathologyHigher severity scoresObsessive-compulsive disorder patientsSymptom dimensionsOCD symptom dimensionsClinical characteristicsFrequent complicationSeverity scoreDepressive disorderMajor depressionPrevalence ratesPsychiatric evaluationDisorder patientsPatientsGeneral psychopathologyDisordersOCD symptoms
2004
Impact of age at onset and duration of illness on the expression of comorbidities in obsessive-compulsive disorder.
Diniz J, Rosario-Campos M, Shavitt R, Curi M, Hounie A, Brotto S, Miguel E. Impact of age at onset and duration of illness on the expression of comorbidities in obsessive-compulsive disorder. The Journal Of Clinical Psychiatry 2004, 65: 22-7. PMID: 14744164, DOI: 10.4088/jcp.v65n0104.Peer-Reviewed Original ResearchConceptsDuration of illnessDepressive disorderTic disordersObsessive-compulsive symptomsExpression of comorbiditiesCommon etiologic pathwayLonger illness durationStructured Clinical InterviewDSM-IV criteriaObsessive-compulsive disorder patientsImpact of ageBody dysmorphic disorderConsecutive outpatientsSecondary complicationsObsessive-compulsive disorderPsychiatric comorbidityIllness durationEtiologic pathwaysDisorder patientsClinical InterviewComorbid diagnosesComorbiditiesIllnessAnxiety disordersDysmorphic disorder
2000
The Psychiatric Symptoms of Rheumatic Fever
Mercadante MT, Busatto GF, Lombroso PJ, Prado L, Rosário-Campos MC, do Valle R, Marques-Dias MJ, Kiss MH, Leckman JF, Miguel EC. The Psychiatric Symptoms of Rheumatic Fever. American Journal Of Psychiatry 2000, 157: 2036-2038. PMID: 11097972, DOI: 10.1176/appi.ajp.157.12.2036.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderRheumatic feverSydenham's choreaTic disordersHigh riskComparison groupFever groupMajor depressive disorderDeficit hyperactivity disorderObsessive-compulsive disorderDepressive disorderRisk factorsPsychiatric symptomsPsychiatric disordersChoreaFeverNeuropsychiatric disordersObsessive-compulsive symptomsRating ScaleHyperactivity disorderSymptomsDisordersADHD symptomsChildrenSemistructured interviews