2022
World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders – Version 3. Part II: OCD and PTSD
Bandelow B, Allgulander C, Baldwin D, da Conceição Costa D, Denys D, Dilbaz N, Domschke K, Hollander E, Kasper S, Möller H, Eriksson E, Fineberg N, Hättenschwiler J, Kaiya H, Karavaeva T, Katzman M, Kim Y, Inoue T, Lim L, Masdrakis V, Menchón J, Miguel E, Nardi A, Pallanti S, Perna G, Rujescu D, Starcevic V, Stein D, Tsai S, Van Ameringen M, Vasileva A, Wang Z, Zohar J. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders – Version 3. Part II: OCD and PTSD. The World Journal Of Biological Psychiatry 2022, 24: 118-134. PMID: 35900217, DOI: 10.1080/15622975.2022.2086296.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsRepetitive transcranial magnetic stimulationCognitive behavioral therapyFirst-line treatmentDeep brain stimulationSSRI treatmentBiological Psychiatry (WFSBP) GuidelinesSecond-line medicationsNon-pharmacological treatmentSerotonin reuptake inhibitorsNon-pharmacological interventionsTreatment-resistant casesTranscranial magnetic stimulationWorld FederationTreatment of anxietyPosttraumatic stress disorderTreatment of OCDReuptake inhibitorsMedication treatmentPharmacological treatmentSNRI venlafaxineInternet-CBTConsensus panelMagnetic stimulationBrain stimulation
2021
Neurocircuitry of Deep Brain Stimulation for Obsessive-Compulsive Disorder as Revealed by Tractography: A Systematic Review
Vieira E, Arantes P, Hamani C, Iglesio R, Duarte K, Teixeira M, Miguel E, Lopes A, Godinho F. Neurocircuitry of Deep Brain Stimulation for Obsessive-Compulsive Disorder as Revealed by Tractography: A Systematic Review. Frontiers In Psychiatry 2021, 12: 680484. PMID: 34276448, PMCID: PMC8280498, DOI: 10.3389/fpsyt.2021.680484.Peer-Reviewed Original ResearchDeep brain stimulationObsessive-compulsive disorderBrain stimulationEffects of DBSMechanisms of DBSRefractory obsessive-compulsive disorderOCD patientsVentral anterior limbDifferent white matter pathwaysCorresponding clinical outcomesDiffusion-weighted imagingDifferent fiber tractsDiffusion tensor imagingPostoperative periodWhite matter pathwaysClinical outcomesInternal capsuleFavorable outcomeDBS effectsDTI-MRIAnterior limbAffective symptomsElectronic databasesWhite matterPatients
2020
Lateral Insertion of Leads and Treatment Outcomes in Ventral Capsule/Ventral Striatum Deep Brain Stimulation for Obsessive-Compulsive Disorder
Lopes A, Godinho F, Murakami M, Iglesio R, Leemans A, Fonoff E, Miguel E, Teixeira M, Arantes P. Lateral Insertion of Leads and Treatment Outcomes in Ventral Capsule/Ventral Striatum Deep Brain Stimulation for Obsessive-Compulsive Disorder. Biological Psychiatry 2020, 87: s191-s192. DOI: 10.1016/j.biopsych.2020.02.500.Peer-Reviewed Original ResearchDeep brain stimulationObsessive-compulsive disorderTreatment outcomesBrain stimulationLateral insertion
2018
Assessment of Safety and Outcome of Lateral Hypothalamic Deep Brain Stimulation for Obesity in a Small Series of Patients With Prader-Willi Syndrome
Franco R, Fonoff E, Alvarenga P, Alho E, Lopes A, Hoexter M, Batistuzzo M, Paiva R, Taub A, Shavitt R, Miguel E, Teixeira M, Damiani D, Hamani C. Assessment of Safety and Outcome of Lateral Hypothalamic Deep Brain Stimulation for Obesity in a Small Series of Patients With Prader-Willi Syndrome. JAMA Network Open 2018, 1: e185275. PMID: 30646396, PMCID: PMC6324383, DOI: 10.1001/jamanetworkopen.2018.5275.Peer-Reviewed Original ResearchConceptsDeep brain stimulationPrader-Willi syndromeBody mass indexBlood workupMass indexSleep studiesHormonal levelsBrain stimulationBaseline mean body mass indexLow-frequency deep brain stimulationOutcome of DBSHigh-frequency deep brain stimulationLong-term deep brain stimulationHypothalamic deep brain stimulationLong-term DBS treatmentMean body mass indexSimilar psychiatric conditionsPrevious bariatric surgeryMonths of treatmentPrimary outcome measureUse of medicationsLateral hypothalamic areaHospital das ClínicasDeep brain stimulation electrodesAssessment of safety
2017
Lateral hypothalamic activity indicates hunger and satiety states in humans
Talakoub O, Paiva R, Milosevic M, Hoexter M, Franco R, Alho E, Navarro J, Pereira J, Popovic M, Savage C, Lopes A, Alvarenga P, Damiani D, Teixeira M, Miguel E, Fonoff E, Batistuzzo M, Hamani C. Lateral hypothalamic activity indicates hunger and satiety states in humans. Annals Of Clinical And Translational Neurology 2017, 4: 897-901. PMID: 29296618, PMCID: PMC5740250, DOI: 10.1002/acn3.466.Peer-Reviewed Original ResearchDeep brain stimulationSatiety stateLateral hypothalamic activityLow gamma activityPrader-Willi patientsFood-related cuesLocal field potentialsHypothalamic activityFood intakeBrain stimulationEarly sensationPatterns of activityAlpha rhythmField potentialsObesityPatientsNeuromodulation studiesHumansSatietyIntakeActivity
2016
DBS for Obesity
Franco R, Fonoff E, Alvarenga P, Lopes A, Miguel E, Teixeira M, Damiani D, Hamani C. DBS for Obesity. Brain Sciences 2016, 6: 21. PMID: 27438859, PMCID: PMC5039450, DOI: 10.3390/brainsci6030021.Peer-Reviewed Original ResearchDeep brain stimulationMorbid obesityUse of DBSDifferent brain targetsNon-negligible incidenceNeurosurgical modalityNumerous comorbiditiesRefractory obesityBariatric surgeryOperative failureEarly mortalitySurgical resultsBrain targetsPrevalent disorderBrain stimulationSide effectsObesityNeuropsychiatric disordersDisordersComorbiditiesPatientsSurgeryBehavioral approachMortalityIncidence
2015
Gamma knife surgery
Lopes A, Batistuzzo M, Gentil A, Hoexter M, Miguel E. Gamma knife surgery. 2015, 369-383. DOI: 10.1002/9781118801086.ch20.Peer-Reviewed Original ResearchSevere adverse eventsGamma Knife surgeryGamma knife radiosurgeryDeep brain stimulationAdverse eventsBrain cystsCase seriesDecreased incidenceObsessive-compulsive disorderSymptom improvementInternal capsuleKnife radiosurgeryAblative proceduresAnterior limbPsychiatric disordersBrain stimulationMajority of studiesRadiosurgical techniquesWhite matter tissueDisordersPatientsSurgeryLesionsRadiosurgeryIncidence
2014
Gamma Ventral Capsulotomy for Obsessive-Compulsive Disorder: A Randomized Clinical Trial
Lopes A, Greenberg B, Canteras M, Batistuzzo M, Hoexter M, Gentil A, Pereira C, Joaquim M, de Mathis M, D’Alcante C, Taub A, de Castro D, Tokeshi L, Sampaio L, Leite C, Shavitt R, Diniz J, Busatto G, Norén G, Rasmussen S, Miguel E. Gamma Ventral Capsulotomy for Obsessive-Compulsive Disorder: A Randomized Clinical Trial. JAMA Psychiatry 2014, 71: 1066-1076. PMID: 25054836, DOI: 10.1001/jamapsychiatry.2014.1193.Peer-Reviewed Original ResearchConceptsIntractable obsessive-compulsive disorderObsessive-compulsive disorderClinical trialsGamma ventral capsulotomyClinical Global Impressions-Improvement scaleSerious adverse eventsRandomized clinical trialsCGI-I ratingsDeep brain stimulationYale-Brown ObsessiveAdverse eventsMonth 12Additional patientsActive treatmentSham groupSymptom improvementInternal capsuleSpecialized centersNeurosurgical ablationAnterior limbMAIN OUTCOMEPsychiatric disordersPatientsOCD symptom improvementSelect cases
2004
Atualização sobre o tratamento neurocirúrgico do transtorno obsessivo-compulsivo
Lopes A, de Mathis M, Canteras M, Salvajoli J, Del Porto J, Miguel E. Atualização sobre o tratamento neurocirúrgico do transtorno obsessivo-compulsivo. Brazilian Journal Of Psychiatry 2004, 26: 62-66. PMID: 15057843, DOI: 10.1590/s1516-44462004000100015.Peer-Reviewed Original ResearchConceptsDeep brain stimulationObsessive-compulsive disorderBrain stimulationOCD patientsSevere OCD patientsPost-operative improvementSevere psychosocial impairmentSevere psychiatric disordersActinic lesionsLimbic leucotomyMedial pallidotomyAdverse eventsAnterior capsulotomyAnterior cingulotomyTreatment trialsSurgical techniquePsychosocial impairmentSurgical proceduresLow prevalencePsychiatric disordersNeural circuitsStereotactic surgeryComplication issuesPersonality changesPatients