2011
Gray Matter Volumes in Obsessive-Compulsive Disorder Before and After Fluoxetine or Cognitive-Behavior Therapy: A Randomized Clinical Trial
Hoexter M, de Souza Duran F, D'Alcante C, Dougherty D, Shavitt R, Lopes A, Diniz J, Deckersbach T, Batistuzzo M, Bressan R, Miguel E, Busatto G. Gray Matter Volumes in Obsessive-Compulsive Disorder Before and After Fluoxetine or Cognitive-Behavior Therapy: A Randomized Clinical Trial. Neuropsychopharmacology 2011, 37: 734-745. PMID: 22030709, PMCID: PMC3260985, DOI: 10.1038/npp.2011.250.Peer-Reviewed Original ResearchConceptsCognitive behavior therapyObsessive-compulsive disorderGray matter volumeLeft putamenClinical trialsOCD patientsGM volumeMatter volumeSignificant GM volume changesPathophysiology of OCDFluoxetine-treated patientsGM volume abnormalitiesMatched-healthy controlsTreatment-naive patientsFirst-line treatmentStructural brain abnormalitiesGM volume changesCBT-treated patientsGroup cognitive behavior therapySmaller GM volumeRegional brain volumesRegional brain morphologyAnterior cingulate cortexStructural magnetic resonanceRegional gray matter volume
2003
How to treat OCD in patients with Tourette syndrome
Miguel E, Shavitt RG, Ferrão YA, Brotto SA, Diniz JB. How to treat OCD in patients with Tourette syndrome. Journal Of Psychosomatic Research 2003, 55: 49-57. PMID: 12842231, DOI: 10.1016/s0022-3999(02)00583-4.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitorsObsessive-compulsive disorderTourette syndromeCognitive behavior therapyOCD patientsCircuit-based therapiesGonadal hormone systemsWorse treatment responsePresence of ticsRefractory patientsAutoimmune processReuptake inhibitorsSuch patientsCombined therapyResistant casesTreatment responseDrug treatmentPharmacological approachesNew therapiesPatientsEffective psychological interventionsTherapyHormone systemPsychological interventions