2022
Deviations from a typical development of the cerebellum in youth are associated with psychopathology, executive functions and educational outcomes
Borges M, Hoffmann M, Simioni A, Axelrud L, Teixeira D, Zugman A, Jackowski A, Pan P, Bressan R, Parker N, Germann J, Bado P, Satterthwaite T, Milham M, Chakravarty M, Rohde L, Miguel E, Paus T, Salum G. Deviations from a typical development of the cerebellum in youth are associated with psychopathology, executive functions and educational outcomes. Psychological Medicine 2022, 53: 5698-5708. PMID: 36226568, DOI: 10.1017/s0033291722002926.Peer-Reviewed Original ResearchConceptsExecutive functionTypical developmentInhibitory controlAcademic achievementCerebellar volumeHigher executive functionChild Behavior ChecklistTypical brain developmentSchool achievementBehavior ChecklistMental health conditionsStandardized measuresMediation analysisMental healthHigh Risk Cohort StudyEducational outcomesPsychopathologyBrain developmentMental conditionLongitudinal analysisYouthSpecific factorsAchievementCognitionAdolescenceDisentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways
Axelrud L, Hoffmann M, Vosberg D, Santoro M, Pan P, Gadelha A, Belangero S, Miguel E, Shin J, Thapar A, Smoller J, Pausova Z, Rohde L, Keller M, Paus T, Salum G. Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways. Journal Of Child Psychology And Psychiatry 2022, 64: 408-416. PMID: 36162806, DOI: 10.1111/jcpp.13708.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderPolygenic scoresOffspring cognitionIntergenerational transmissionMultiple mediation modelEducational attainmentBehavioral traitsCognitive measuresExecutive functionGeneral intelligenceHyperactivity disorderMediation modelMultiple mediationCognitive AssessmentCognitionPsychopathologyGenetic influencesParental educationPsychotic symptomsDirect associationParental geneticsAttainmentDiscovery sampleGenetic riskFathersThreat and deprivation are associated with distinct aspects of cognition, emotional processing, and psychopathology in children and adolescents
Schäfer J, McLaughlin K, Manfro G, Pan P, Rohde L, Miguel E, Simioni A, Hoffmann M, Salum G. Threat and deprivation are associated with distinct aspects of cognition, emotional processing, and psychopathology in children and adolescents. Developmental Science 2022, 26: e13267. PMID: 35417607, PMCID: PMC10028496, DOI: 10.1111/desc.13267.Peer-Reviewed Original ResearchConceptsChild Behavior ChecklistExecutive functionEmotional processingChildhood adversityBrazilian High-Risk CohortForms of adversityPoor developmental outcomesAttention biasAngry facesCognitive tasksCognitive developmentDevelopmental correlatesBehavior ChecklistChild developmentDevelopmental outcomesLongitudinal associationsGeneral psychopathologyPsychopathologyAdversityLatent constructsDifferential associationsWorse performanceDistinct aspectsCognitionMeaningful influence
2021
Cognitive decline following acute viral infections: literature review and projections for post-COVID-19
Damiano R, Guedes B, de Rocca C, de Pádua Serafim A, Castro L, Munhoz C, Nitrini R, Filho G, Miguel E, Lucchetti G, Forlenza O. Cognitive decline following acute viral infections: literature review and projections for post-COVID-19. European Archives Of Psychiatry And Clinical Neuroscience 2021, 272: 139-154. PMID: 34173049, PMCID: PMC8231753, DOI: 10.1007/s00406-021-01286-4.Peer-Reviewed Original ResearchConceptsAcute viral infectionViral infectionCognitive declineHuman cognitionCoronavirus disease 2019Possible cognitive declineAsymptomatic individualsBrain dysfunctionDisease 2019Human dementiaNeuropsychiatric issuesCognitive sequelaeAlzheimer's diseaseNarrative reviewInfectionInfectious diseasesHealth leadersDiseaseCOVID-19COVID-19 pandemicIndirect pathwaysCognitionCurrent knowledgeRecent findingsLiterature review
2018
Polygenic Risk Score for Alzheimer’s Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life
Axelrud L, Santoro M, Pine D, Talarico F, Gadelha A, Manfro G, Pan P, Jackowski A, Picon F, Brietzke E, Grassi-Oliveira R, Bressan R, Miguel E, Rohde L, Hakonarson H, Pausova Z, Belangero S, Paus T, Salum G. Polygenic Risk Score for Alzheimer’s Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life. American Journal Of Psychiatry 2018, 175: 555-563. PMID: 29495896, PMCID: PMC6372950, DOI: 10.1176/appi.ajp.2017.17050529.Peer-Reviewed Original ResearchConceptsHippocampal volumeEarly-life cognitionCanadian sampleMemory taskCognitive abilitiesExecutive functionImmediate recallMemory performanceCognitive testsGenetic riskReplication sampleBrain algorithmPolygenic risk scoresStandardized testsLower hippocampal volumeDistinct tasksBrain structuresAlzheimer's diseaseCognitionIndependent samplesLate-life dementiaDevelopmental conditionsRecallPrevious evidenceTask
1997
Phenomenological differences appearing with repetitive behaviours in obsessive-compulsive disorder and Gilles de la Tourette's syndrome
Miguel E, Baer L, Coffey B, Rauch S, Savage C, O'Sullivan R, Phillips K, Moretti C, Leckman J, Jenike M. Phenomenological differences appearing with repetitive behaviours in obsessive-compulsive disorder and Gilles de la Tourette's syndrome. The British Journal Of Psychiatry 1997, 170: 140-145. PMID: 9093502, DOI: 10.1192/bjp.170.2.140.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRepetitive behaviorsSensory phenomenaAutonomic anxietyMore cognitionsOCD groupGilles de la Tourette's syndromeOCD subtypesSubjective experienceGTS groupSemi-structured interviewsCognitionTourette syndromeValid predictorPhenomenological differencesAnxietyLa Tourette's syndromeAdult outpatientsPhenomenological studyDisordersBehaviorTreatment responsePredictorsInterviewsExperience
1995
Phenomenology of intentional repetitive behaviors in obsessive-compulsive disorder and Tourette's disorder.
Miguel E, Coffey B, Baer L, Savage C, Rauch S, Jenike M. Phenomenology of intentional repetitive behaviors in obsessive-compulsive disorder and Tourette's disorder. The Journal Of Clinical Psychiatry 1995, 56: 246-55. PMID: 7775367.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRepetitive behaviorsOCD patientsCognitive phenomenaSensory phenomenaAutonomic anxietyComorbid obsessive-compulsive disorderTourette's disorderAffective experienceSuch sensationsTourette's subjectsAnxietyCognitionOCD outpatientsStructured interviewsTourette patientsDisordersSuch symptomsTouretteBehaviorRecent evidenceOutpatientsSubjectsInterviewsPhenomenology