2021
Association Between Obsessive-Compulsive Symptom Dimensions in Mothers and Psychopathology in Their Children
Blanco-Vieira T, Hoexter M, Batistuzzo M, Alvarenga P, Szejko N, Fumo A, Miguel E, do Rosário M. Association Between Obsessive-Compulsive Symptom Dimensions in Mothers and Psychopathology in Their Children. Frontiers In Psychiatry 2021, 12: 674261. PMID: 34262490, PMCID: PMC8273307, DOI: 10.3389/fpsyt.2021.674261.Peer-Reviewed Original ResearchPresence of OCSObsessive-compulsive symptomsChild Behavior ChecklistMini-International Psychiatric InterviewPsychopathology statusSymptom dimensionsBehavioral problemsNon-clinical presentationsYale-Brown ObsessiveAggression/violenceClinical variablesOverall prevalenceSchool-aged childrenPsychiatric interviewMaternal psychopathologyMother-child dyadsDimensional Yale-Brown ObsessiveSubscale scoresOwn psychopathologyMothersBehavior ChecklistMultiple regression analysisSignificant correlationRegression analysisCellular and Extracellular White Matter Abnormalities in Obsessive-Compulsive Disorder: A Diffusion Magnetic Resonance Imaging Study
Maziero M, Seitz-Holland J, Cho K, Goldenberg J, Tanamatis T, Diniz J, Cappi C, Alice de Mathis M, Otaduy M, da Graça Morais Martin M, de Melo Felipe da Silva R, Shavitt R, Batistuzzo M, Lopes A, Miguel E, Pasternak O, Hoexter M. Cellular and Extracellular White Matter Abnormalities in Obsessive-Compulsive Disorder: A Diffusion Magnetic Resonance Imaging Study. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2021, 6: 983-991. PMID: 33862255, PMCID: PMC8502196, DOI: 10.1016/j.bpsc.2021.04.001.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderClinical variablesControl subjectsLower fractional anisotropyFractional anisotropyWhite matterDiffusion-weighted magnetic resonance imagingMagnetic resonance imaging studyDiffusion measuresDiffusion magnetic resonance imaging studyWhite matter abnormalitiesTract-based spatial statisticsResonance imaging studyMagnetic resonance imagingFree-water imagingExtracellular abnormalities
2017
Comorbidity, age of onset and suicidality in obsessive–compulsive disorder (OCD): An international collaboration
Brakoulias V, Starcevic V, Belloch A, Brown C, Ferrao Y, Fontenelle L, Lochner C, Marazziti D, Matsunaga H, Miguel E, Reddy Y, do Rosario M, Shavitt R, Sundar A, Stein D, Torres A, Viswasam K. Comorbidity, age of onset and suicidality in obsessive–compulsive disorder (OCD): An international collaboration. Comprehensive Psychiatry 2017, 76: 79-86. PMID: 28433854, DOI: 10.1016/j.comppsych.2017.04.002.Peer-Reviewed Original ResearchConceptsAge of onsetObsessive-compulsive disorderMajor depressive disorderComorbid disordersPsychiatric comorbidityAnxiety disordersSpecific phobiaDepressive disorderMajor depressionSuicidal ideationCo-occurring major depressive disorderLifetime psychiatric comorbiditySocial phobiaCurrent comorbid disordersPatterns of comorbidityComorbid major depressionPrimary obsessive-compulsive disorderDisorder treatment centersEarly ageBody dysmorphic disorderAdult patientsObsessive-compulsive personality disorderPsychiatric diagnostic classificationClinical variablesOCD comorbidity
2015
Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder
de Wit S, Alonso P, Schweren L, Mataix-Cols D, Lochner C, Menchón J, Stein D, Fouche J, Soriano-Mas C, Sato J, Hoexter M, Denys D, Nakamae T, Nishida S, Kwon J, Jang J, Busatto G, Cardoner N, Cath D, Fukui K, Jung W, Kim S, Miguel E, Narumoto J, Phillips M, Pujol J, Remijnse P, Sakai Y, Shin N, Yamada K, Veltman D, van den Heuvel O. Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder. FOCUS The Journal Of Lifelong Learning In Psychiatry 2015, 13: 204-212. DOI: 10.1176/appi.focus.130210.Peer-Reviewed Original ResearchHealthy comparison subjectsObsessive-compulsive disorderOCD patientsHealthy subjectsComparison subjectsMatter volumeGreater cerebellar gray matter volumeStructural T1-weighted MRI scansWhite matter brain volumesWhite matter volume differencesT1-weighted MRI scansWhite matter volumePrevious smaller studiesStructural brain scansGray matter volumeCerebellar gray matter volumeVoxel-based morphometryAdult OCD patientsAnterior cingulate cortexAltered neuroplasticityClinical variablesInferior frontal gyrusCognitive dysfunctionDorsomedial prefrontal cortexMRI scans
2014
Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder
de Wit S, Alonso P, Schweren L, Mataix-Cols D, Lochner C, Menchón J, Stein D, Fouche J, Soriano-Mas C, Sato J, Hoexter M, Denys D, Nakamae T, Nishida S, Kwon J, Jang J, Busatto G, Cardoner N, Cath D, Fukui K, Jung W, Kim S, Miguel E, Narumoto J, Phillips M, Pujol J, Remijnse P, Sakai Y, Shin N, Yamada K, Veltman D, van den Heuvel O. Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder. American Journal Of Psychiatry 2014, 171: 340-349. PMID: 24220667, DOI: 10.1176/appi.ajp.2013.13040574.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsObsessive-compulsive disorderOCD patientsHealthy subjectsComparison subjectsGreater cerebellar gray matter volumeMatter volumeStructural T1-weighted MRI scansWhite matter brain volumesWhite matter volume differencesT1-weighted MRI scansWhite matter volumePrevious smaller studiesStructural brain scansGray matter volumeVoxel-based morphometryAdult OCD patientsCerebellar gray matter volumeAnterior cingulate cortexAltered neuroplasticityClinical variablesInferior frontal gyrusCognitive dysfunctionDorsomedial prefrontal cortexTemporal cortex
2012
CLINICAL PREDICTORS OF LONG‐TERM OUTCOME IN OBSESSIVE‐COMPULSIVE DISORDER
Jakubovski E, Diniz J, Valerio C, Fossaluza V, Belotto‐Silva C, Gorenstein C, Miguel E, Shavitt R. CLINICAL PREDICTORS OF LONG‐TERM OUTCOME IN OBSESSIVE‐COMPULSIVE DISORDER. Depression And Anxiety 2012, 30: 763-772. PMID: 23109056, DOI: 10.1002/da.22013.Peer-Reviewed Original ResearchConceptsLong-term outcomesObsessive-compulsive disorderPositive family historyGroup cognitive behavioral therapyDepressive disorderFamily historyOCD patientsOnset of OCDInitial treatment modalityComorbid psychiatric disordersPercent of subjectsBeck depression scoresDuration of OCDCognitive behavioral therapyYale-Brown ObsessiveUntreated patientsClinical factorsClinical predictorsInitial treatmentOpen trialWorse prognosisClinical variablesPharmacological treatmentPsychiatric comorbidityTreatment modalities