2023
Gamma knife capsulotomy for intractable OCD: Neuroimage analysis of lesion size, location, and clinical response
McLaughlin N, Magnotti J, Banks G, Nanda P, Hoexter M, Lopes A, Batistuzzo M, Asaad W, Stewart C, Paulo D, Noren G, Greenberg B, Malloy P, Salloway S, Correia S, Pathak Y, Sheehan J, Marsland R, Gorgulho A, De Salles A, Miguel E, Rasmussen S, Sheth S. Gamma knife capsulotomy for intractable OCD: Neuroimage analysis of lesion size, location, and clinical response. Translational Psychiatry 2023, 13: 134. PMID: 37185805, PMCID: PMC10130137, DOI: 10.1038/s41398-023-02425-2.Peer-Reviewed Original ResearchConceptsY-BOCS reductionObsessive-compulsive disorderGamma knife capsulotomyLesion sizeRefractory obsessive-compulsive disorderOverall lesion volumeIntractable obsessive-compulsive disorderLesion-symptom mappingVoxel-wise lesion-symptom mappingClinical improvementClinical responseWhite matter pathwaysClinical outcomesFull respondersConventional therapyInternal capsuleLesion characteristicsLesion volumeAnterior limbEffective treatmentLesion locationLesion occurrenceCoronal planeSize/locationPatients
2020
Obsessive–Compulsive Personality Symptoms Predict Poorer Response to Gamma Ventral Capsulotomy for Intractable OCD
Copetti M, Lopes A, Requena G, Johnson I, Greenberg B, Noren G, McLaughlin N, Shavitt R, Miguel E, Batistuzzo M, Hoexter M. Obsessive–Compulsive Personality Symptoms Predict Poorer Response to Gamma Ventral Capsulotomy for Intractable OCD. Frontiers In Psychiatry 2020, 10: 936. PMID: 31998155, PMCID: PMC6962231, DOI: 10.3389/fpsyt.2019.00936.Peer-Reviewed Original ResearchGamma ventral capsulotomyPersonality disorder symptomsIntractable obsessive-compulsive disorderObsessive-compulsive disorderDisorder symptomsOCD patientsTreatment responseDisorder symptom changeSymptom changeStructured Clinical InterviewWorse treatment responseDSM-IV personality disordersWilcoxon signed-rank testPoorer ResponseClinical responseTreatment optionsInternal capsuleSigned-rank testTreatment attemptsAnterior limbClinical InterviewRadiosurgical proceduresPatientsSymptomsVentral part
2010
Response to Sham and Active Gamma Ventral Capsulotomy in Otherwise Intractable Obsessive-Compulsive Disorder
Gouvea F, Lopes A, Greenberg B, Canteras M, Taub A, Mathis M, Miguel E. Response to Sham and Active Gamma Ventral Capsulotomy in Otherwise Intractable Obsessive-Compulsive Disorder. Stereotactic And Functional Neurosurgery 2010, 88: 177-182. PMID: 20431329, DOI: 10.1159/000313870.Peer-Reviewed Original ResearchConceptsRefractory obsessive-compulsive disorderGamma ventral capsulotomyClinical responseSham surgeryObsessive-compulsive disorderSurgical techniquePsychopathological changesRadiosurgical proceduresRemarkable ameliorationActive interventionCompulsive disorderDisordersActive procedureCapsulotomySurgeryShamRadiosurgery