2024
Is waiting for rewards good for you? No association between impulsive choice, psychopathology, and functional outcomes in a large cohort sample
Bado P, Salum G, Rohde L, Gadelha A, Pan P, Miguel E, Tripp G, Furukawa E. Is waiting for rewards good for you? No association between impulsive choice, psychopathology, and functional outcomes in a large cohort sample. JCPP Advances 2024, 4: e12231. PMID: 38827985, PMCID: PMC11143955, DOI: 10.1002/jcv2.12231.Peer-Reviewed Original ResearchDelayed rewardsPsychiatric conditionsPresence of psychiatric disordersLife outcomesBaseline task performanceImpulsive choicePositive long-term outcomesImmediate rewardsPsychiatric disordersTask performanceADHDResults ChildrenRewardChildren's preferencesStronger preferenceSchool-based cohortDisordersLongitudinal outcomesCohort sampleFunctional outcomesChildrenCohort of Brazilian childrenBrazilian childrenPsychopathologyDiverse populations
2023
Longitudinal invariance of psychotic experiences in children and adolescents: What do the data tell us?
Barbosa M, Machado V, Ziebold C, Moriyama T, Bressan R, Pan P, Rohde L, Miguel E, Fonseca L, Van Os J, Gadelha A. Longitudinal invariance of psychotic experiences in children and adolescents: What do the data tell us? Schizophrenia Research 2023, 255: 33-40. PMID: 36958268, DOI: 10.1016/j.schres.2023.03.003.Peer-Reviewed Original ResearchConceptsPsychotic experiencesTime pointsHigh-risk cohortPrevious systematic reviewDifferent age groupsDifferent time pointsBaseline evaluationLifetime psychotic experiencesPositive symptomsSystematic reviewAge groupsPerceptual abnormalitiesLongitudinal studyBrazilian High-Risk CohortPsychosis pronenessGood model fit indicesThree-factor solutionChildren
2021
Long‐term stability of the cortical volumetric profile and the functional human connectome throughout childhood and adolescence
Sato J, Biazoli C, Zugman A, Pan P, Bueno A, Moura L, Gadelha A, Picon F, Amaro E, Salum G, Miguel E, Rohde L, Bressan R, Jackowski A. Long‐term stability of the cortical volumetric profile and the functional human connectome throughout childhood and adolescence. European Journal Of Neuroscience 2021, 54: 6187-6201. PMID: 34460993, DOI: 10.1111/ejn.15435.Peer-Reviewed Original ResearchConceptsFunctional connectomeVolumetric profileLarge-scale functional networksDorsal attention networkBrain functional connectomeIdentification accuracyStructural brain featuresFunctional connectivity profilesProtracted developmentBrain featuresConnectivity profilesFunctional networksHuman connectomeConnectomeNeurodevelopmental processesLongitudinal cohortAdolescenceAdolescentsWhole brainSubject variabilityChildrenChildhoodLarge-scale networksScan intervalFunctional profilesPredictors of gaming disorder in children and adolescents: a school-based study
Ferreira F, Bambini B, Tonsig G, Fonseca L, Picon F, Pan P, Salum G, Jackowski A, Miguel E, Rohde L, Bressan R, Gadelha A. Predictors of gaming disorder in children and adolescents: a school-based study. Brazilian Journal Of Psychiatry 2021, 43: 289-292. PMID: 32756806, PMCID: PMC8136393, DOI: 10.1590/1516-4446-2020-0964.Peer-Reviewed Original ResearchConceptsMental disordersWell-Being Behavior AssessmentHigh-risk cohortLogistic regression modelsSchool-based studyGaming disorderPsychiatric disordersUnhealthy patternsDisorder ratesSchool-based sampleDisordersSignificant predictorsFurther riskBrazilian High-Risk CohortCommunity sampleHigh rateBehavior changeMore hoursRegression modelsChildrenPredictorsAdolescentsHoursBehavior assessmentPattern variables
2019
Relationships between childhood maltreatment, impairment in executive functions and disruptive behavior disorders in a community sample of children
Bernardes E, Manitto A, Miguel E, Pan P, Batistuzzo M, Rohde L, Polanczyk G. Relationships between childhood maltreatment, impairment in executive functions and disruptive behavior disorders in a community sample of children. European Child & Adolescent Psychiatry 2019, 29: 969-978. PMID: 31559500, DOI: 10.1007/s00787-019-01408-3.Peer-Reviewed Original ResearchConceptsDisruptive behavior disordersExecutive functionChildhood maltreatmentCognitive flexibilityEF performanceCommunity sampleBehavior disorderSchool-based sampleCognitive mechanismsCognitive tasksInhibitory controlDisruptive behaviorChild maltreatmentMaltreatmentWorse performanceMental disordersModeratorChildrenImpairmentDisordersIndependent relationshipMemoryFuture studiesAssociationTaskCaudate volume differences among treatment responders, non-responders and controls in children with obsessive–compulsive disorder
Vattimo E, Barros V, Requena G, Sato J, Fatori D, Miguel E, Shavitt R, Hoexter M, Batistuzzo M. Caudate volume differences among treatment responders, non-responders and controls in children with obsessive–compulsive disorder. European Child & Adolescent Psychiatry 2019, 28: 1607-1617. PMID: 30972581, DOI: 10.1007/s00787-019-01320-w.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderGroup cognitive behavioral therapyPediatric obsessive-compulsive disorderRight caudateTreatment responseCognitive behavioral therapyCaudate nucleusPossible neural substrateTreatment respondersGM volumeStructural magnetic resonance imagingNeural substratesPrevious evidenceNeurobiological underpinningsOrbitofrontal cortexAge-matched controlsTotal GM volumeMagnetic resonance imagingBrain structuresResonance imagingChildrenRespondersBonferroni correctionCaudatePatientsUse of Mental Health Services by Children With Mental Disorders in Two Major Cities in Brazil
Fatori D, Salum G, Rohde L, Pan P, Bressan R, Evans-Lacko S, Polanczyk G, Miguel E, Graeff-Martins A. Use of Mental Health Services by Children With Mental Disorders in Two Major Cities in Brazil. Psychiatric Services 2019, 70: 337-341. PMID: 30651056, DOI: 10.1176/appi.ps.201800389.Peer-Reviewed Original ResearchConceptsMental health servicesMental disordersUnmet needHealth servicesHigh Risk Cohort StudyCombination of psychotherapyMental health treatmentChildren ages 6Cohort studyHealth treatmentCommunity studyAge 6DisordersHealth careLifetime useWhite childrenChildrenHigh rateTreatmentCurrent studyPorto AlegreSao PauloMedicationsPsychotherapyDiagnosis
2018
Prevalência de problemas de saúde mental na infância na atenção primária
Fatori D, Brentani A, Grisi S, Miguel E, Graeff-Martins A. Prevalência de problemas de saúde mental na infância na atenção primária. Ciência & Saúde Coletiva 2018, 23: 3013-3020. PMID: 30281738, DOI: 10.1590/1413-81232018239.25332016.Peer-Reviewed Original ResearchConceptsMental health problemsPrimary healthcare unitsHealth professionalsHealth problemsPrimary care settingHealth service usePrevalence of internalizingPublic health problemPresent population studyMental health professionalsMedication treatmentYear old childrenHigh prevalenceCare settingsAtenção primáriaService useHealth servicesSample of childrenOlder childrenPrevalenceTreatment constituteDifficulties QuestionnairePopulation studiesHealthcare unitsChildrenSocioeconomic diversities and infant development at 6 to 9 months in a poverty area of São Paulo, Brazil
Tella P, da Rosa Piccolo L, Rangel M, Rohde L, Polanczyk G, Miguel E, Grisi S, Fleitlich-Bilyk B, Ferraro A. Socioeconomic diversities and infant development at 6 to 9 months in a poverty area of São Paulo, Brazil. Trends In Psychiatry And Psychotherapy 2018, 40: 232-240. PMID: 30156646, DOI: 10.1590/2237-6089-2017-0008.Peer-Reviewed Original ResearchConceptsCognitive developmentInfant developmentInfant languageInfants' performanceMaternal educationCognitive scoresMotor skillsSocioeconomic statusIntervention effortsBayley ScalesHigh languageSES effectsParticipant familiesEarly childhoodMotor ScaleLanguageSocioeconomic backgroundHigher maternal educationPositive associationChildhoodSocioeconomic diversityInfancySkillsFirst yearChildrenAdaptive treatment strategies for children and adolescents with Obsessive-Compulsive Disorder: A sequential multiple assignment randomized trial
Fatori D, de Bragança Pereira CA, Asbahr FR, Requena G, Alvarenga PG, de Mathis MA, Rohde LA, Leckman JF, March JS, Polanczyk GV, Miguel EC, Shavitt RG. Adaptive treatment strategies for children and adolescents with Obsessive-Compulsive Disorder: A sequential multiple assignment randomized trial. Journal Of Anxiety Disorders 2018, 58: 42-50. PMID: 30025255, DOI: 10.1016/j.janxdis.2018.07.002.Peer-Reviewed Original ResearchConceptsGroup cognitive behavioral therapySequential multiple assignmentTreatment failureInitial treatmentBaseline Yale-Brown ObsessiveChildhood OCDEffective initial treatmentProvision of treatmentCompulsive Scale scoresCognitive behavioral therapyAdaptive treatment strategiesYale-Brown ObsessiveSame regimenObsessive-compulsive disorderTreatment strategiesSymptom reductionPrimary analysisScale scoreFluoxetineTime pointsWeeksTreatmentChildrenEffect sizeTrialsChildhood trauma and adolescent psychotic experiences in a community-based cohort: The potential role of positive attributes as a protective factor
Pan P, Gadelha A, Argolo F, Hoffmann M, Arcadepani F, Miguel E, Rohde L, McGuire P, Salum G, Bressan R. Childhood trauma and adolescent psychotic experiences in a community-based cohort: The potential role of positive attributes as a protective factor. Schizophrenia Research 2018, 205: 23-29. PMID: 30879477, DOI: 10.1016/j.schres.2018.06.044.Peer-Reviewed Original ResearchConceptsChildhood traumaPsychotic experiencesPositive attributesSelf-reported psychotic experiencesIndirect effectsBaseline psychotic experiencesHigh childhood traumaMediation modelAdolescent psychotic experiencesYear old childrenPersonality characteristicsProtective factorsPreventive interventionsBehavioral traitsHigh levelsIndirect pathwaysChildrenTraumaPsychologistsAdolescenceExperienceParentsRelationshipAttributesTime pointsObsessive-compulsive symptoms in children with first degree relatives diagnosed with obsessive-compulsive disorder
Chacon P, Bernardes E, Faggian L, Batistuzzo M, Moriyama T, Miguel E, Polanczyk G. Obsessive-compulsive symptoms in children with first degree relatives diagnosed with obsessive-compulsive disorder. Brazilian Journal Of Psychiatry 2018, 40: 388-393. PMID: 29898190, PMCID: PMC6899383, DOI: 10.1590/1516-4446-2017-2321.Peer-Reviewed Original ResearchConceptsPresence of OCSObsessive-compulsive disorderFirst-degree relativesObsessive-compulsive symptomsSocioeconomic statusImportant risk factorLow socioeconomic statusFuture longitudinal studiesClinical correlatesAssessed childrenRisk factorsDegree relativesFamily historySymptomsContamination/Longitudinal studyOCD diagnosisDisordersChildrenHigh rateFamily membersChildhoodCorrelatesStatusThe economic impact of subthreshold and clinical childhood mental disorders
Fatori D, Salum G, Itria A, Pan P, Alvarenga P, Rohde L, Bressan R, Gadelha A, de Jesus Mari J, do Rosário M, Manfro G, Polanczyk G, Miguel E, Graeff-Martins A. The economic impact of subthreshold and clinical childhood mental disorders. Journal Of Mental Health 2018, 27: 588-594. PMID: 29708045, DOI: 10.1080/09638237.2018.1466041.Peer-Reviewed Original ResearchConceptsSubthreshold mental disordersClinical mental disordersMental disordersHigh Risk Cohort StudyCommon health problemLifetime cost estimatesChild mental disordersChildhood mental disordersWell-Being AssessmentSocial service useCohort studyYear old childrenService useEconomic burdenCost-effective programsHealth problemsBrazilian childrenCommunity studyMental healthOlder childrenDisordersDisorder assessmentSerious impairmentMajor Brazilian citiesChildren
2017
Gene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder
Spindola L, Pan P, Moretti P, Ota V, Santoro M, Cogo-Moreira H, Gadelha A, Salum G, Manfro G, Mari J, Brentani H, Grassi-Oliveira R, Brietzke E, Miguel E, Rohde L, Sato J, Bressan R, Belangero S. Gene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder. Journal Of Psychiatric Research 2017, 92: 24-30. PMID: 28384542, DOI: 10.1016/j.jpsychires.2017.03.015.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild AbuseCohort StudiesDepressive Disorder, MajorFemaleGene ExpressionGenetic TestingHumansHypothalamo-Hypophyseal SystemInterleukin-1betaMaleModels, BiologicalPeptide FragmentsPituitary-Adrenal SystemReceptors, GlucocorticoidReceptors, Tumor Necrosis Factor, Type IResidence CharacteristicsRNA, MessengerTumor Necrosis Factor-alphaConceptsMajor depressive disorderBlood of childrenDepressive disorderChildhood maltreatmentMDD diagnosisRole of glucocorticoidsWhole blood mRNA levelsCM historyGene expressionAdrenal axisIllness exposureHealthy controlsDepressive symptomsMDD groupLarger studyMRNA expressionMRNA levelsExpression levelsInflammationTNFChildrenDiagnosisBloodAdolescentsNR3C1M31 Gene Expression In Blood of Children And Adolescents: Influence of Environmental Stressors On Major Depressive Disorder
Spindola L, Pan P, Moretti P, Ota V, Santoro M, Cogo-Moreira H, Gadelha A, Salum G, Manfro G, Mari J, Brentani H, Grassi-Oliveira R, Brietzke E, Miguel E, Rohde L, Sato J, Bressan R, Belangero S. M31 Gene Expression In Blood of Children And Adolescents: Influence of Environmental Stressors On Major Depressive Disorder. European Neuropsychopharmacology 2017, 27: s387-s388. DOI: 10.1016/j.euroneuro.2016.09.422.Peer-Reviewed Original ResearchMajor depressive disorderBlood of childrenPrenatal alcoholDepressive disorderChildhood maltreatmentMDD diagnosisPt exposureRole of glucocorticoidsPeripheral mRNA expressionGene expressionTobacco exposureIllness exposureHealthy controlsIL1B expressionDepressive symptomsMDD groupLarger studyMRNA expressionWhole bloodDisordersBloodExpression levelsInflammationTNFChildren
2016
Connectome hubs at resting state in children and adolescents: Reproducibility and psychopathological correlation
Sato J, Biazoli C, Salum G, Gadelha A, Crossley N, Vieira G, Zugman A, Picon F, Pan P, Hoexter M, Anés M, Moura L, Del’Aquilla M, Amaro E, Mcguire P, Rohde L, Miguel E, Bressan R, Jackowski A. Connectome hubs at resting state in children and adolescents: Reproducibility and psychopathological correlation. Developmental Cognitive Neuroscience 2016, 20: 2-11. PMID: 27288820, PMCID: PMC6987719, DOI: 10.1016/j.dcn.2016.05.002.Peer-Reviewed Original ResearchConceptsAnterior medial prefrontal cortexPsychiatric symptomsLarge-scale functional networksBrain hubsMental disordersHub regionsMedial prefrontal cortexResting-state fMRIFunctional cortical networksIndependent population-based samplesRight IPSPopulation-based sampleIntraparietal sulcusBrain networksPrefrontal cortexCortical networksIntegrative regionsFunctional networksAdolescentsLow centralitySymptomsChildrenDisordersReplicabilityInteresting target
2015
Temporal stability of network centrality in control and default mode networks: Specific associations with externalizing psychopathology in children and adolescents
Sato J, Biazoli C, Salum G, Gadelha A, Crossley N, Satterthwaite T, Vieira G, Zugman A, Picon F, Pan P, Hoexter M, Anés M, Moura L, Del'aquilla M, Amaro E, McGuire P, Lacerda A, Rohde L, Miguel E, Jackowski A, Bressan R. Temporal stability of network centrality in control and default mode networks: Specific associations with externalizing psychopathology in children and adolescents. Human Brain Mapping 2015, 36: 4926-4937. PMID: 26350757, PMCID: PMC6868942, DOI: 10.1002/hbm.22985.Peer-Reviewed Original ResearchConceptsDefault mode networkChild Behavior ChecklistDynamic functional connectivity patternsHigh Risk Cohort StudyBehavior ChecklistAbnormal connectivity patternsFunctional connectivity patternsResting-state fMRIPathological mental statesCohort studyConnectivity patternsPsychiatric disordersFunctional network dynamicsGeneral psychopathologyTotal scoreMode networkNetwork maturationBrain networksMaturation indexEmotional problemsChildrenAge effectsOverall presenceSpecific associationAdolescentsDefault mode network maturation and psychopathology in children and adolescents
Sato J, Salum G, Gadelha A, Crossley N, Vieira G, Manfro G, Zugman A, Picon F, Pan P, Hoexter M, Anés M, Moura L, Del'Aquilla M, Amaro E, McGuire P, Lacerda A, Rohde L, Miguel E, Jackowski A, Bressan R. Default mode network maturation and psychopathology in children and adolescents. Journal Of Child Psychology And Psychiatry 2015, 57: 55-64. PMID: 26111611, DOI: 10.1111/jcpp.12444.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingChild Behavior ChecklistMental health disordersResting-state protocolPsychopathology scoresHealth disordersBehavior ChecklistDefault modeChild psychopathologyDeviant trajectoriesNeurodevelopmental trajectoriesAge of participantsBrain maturationLow-frequency fluctuationsPsychopathologyChronological ageFractional amplitudeMental disordersDMNGeneral psychopathology scoresNetwork maturationAge predictionChildrenPredictor variablesDisorders
2014
High risk cohort study for psychiatric disorders in childhood: rationale, design, methods and preliminary results
Salum G, Gadelha A, Pan P, Moriyama T, Graeff‐Martins A, Tamanaha A, Alvarenga P, Krieger F, Fleitlich‐Bilyk B, Jackowski A, Sato J, Brietzke E, Polanczyk G, Brentani H, de Jesus Mari J, Do Rosário M, Manfro G, Bressan R, Mercadante M, Miguel E, Rohde L. High risk cohort study for psychiatric disorders in childhood: rationale, design, methods and preliminary results. International Journal Of Methods In Psychiatric Research 2014, 24: 58-73. PMID: 25469819, PMCID: PMC6878239, DOI: 10.1002/mpr.1459.Peer-Reviewed Original ResearchConceptsHigh Risk Cohort StudyMental disordersCohort studyPsychiatric disordersHigh-risk stratumChild mental disordersChildhood psychiatric disordersUseful clinical informationDiagnostic instrumentHigh riskClinical informationScreening instrumentFamily psychopathologyDisordersBaseline phaseScreening procedureChild psychiatryChildrenParticipation ratesPreliminary resultsPrevalenceStudyFamily rates
2000
The Psychiatric Symptoms of Rheumatic Fever
Mercadante MT, Busatto GF, Lombroso PJ, Prado L, Rosário-Campos MC, do Valle R, Marques-Dias MJ, Kiss MH, Leckman JF, Miguel EC. The Psychiatric Symptoms of Rheumatic Fever. American Journal Of Psychiatry 2000, 157: 2036-2038. PMID: 11097972, DOI: 10.1176/appi.ajp.157.12.2036.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderRheumatic feverSydenham's choreaTic disordersHigh riskComparison groupFever groupMajor depressive disorderDeficit hyperactivity disorderObsessive-compulsive disorderDepressive disorderRisk factorsPsychiatric symptomsPsychiatric disordersChoreaFeverNeuropsychiatric disordersObsessive-compulsive symptomsRating ScaleHyperactivity disorderSymptomsDisordersADHD symptomsChildrenSemistructured interviews