2019
Relationships between childhood maltreatment, impairment in executive functions and disruptive behavior disorders in a community sample of children
Bernardes E, Manitto A, Miguel E, Pan P, Batistuzzo M, Rohde L, Polanczyk G. Relationships between childhood maltreatment, impairment in executive functions and disruptive behavior disorders in a community sample of children. European Child & Adolescent Psychiatry 2019, 29: 969-978. PMID: 31559500, DOI: 10.1007/s00787-019-01408-3.Peer-Reviewed Original ResearchConceptsDisruptive behavior disordersExecutive functionChildhood maltreatmentCognitive flexibilityEF performanceCommunity sampleBehavior disorderSchool-based sampleCognitive mechanismsCognitive tasksInhibitory controlDisruptive behaviorChild maltreatmentMaltreatmentWorse performanceMental disordersModeratorChildrenImpairmentDisordersIndependent relationshipMemoryFuture studiesAssociationTask
2017
Gene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder
Spindola L, Pan P, Moretti P, Ota V, Santoro M, Cogo-Moreira H, Gadelha A, Salum G, Manfro G, Mari J, Brentani H, Grassi-Oliveira R, Brietzke E, Miguel E, Rohde L, Sato J, Bressan R, Belangero S. Gene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder. Journal Of Psychiatric Research 2017, 92: 24-30. PMID: 28384542, DOI: 10.1016/j.jpsychires.2017.03.015.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild AbuseCohort StudiesDepressive Disorder, MajorFemaleGene ExpressionGenetic TestingHumansHypothalamo-Hypophyseal SystemInterleukin-1betaMaleModels, BiologicalPeptide FragmentsPituitary-Adrenal SystemReceptors, GlucocorticoidReceptors, Tumor Necrosis Factor, Type IResidence CharacteristicsRNA, MessengerTumor Necrosis Factor-alphaConceptsMajor depressive disorderBlood of childrenDepressive disorderChildhood maltreatmentMDD diagnosisRole of glucocorticoidsWhole blood mRNA levelsCM historyGene expressionAdrenal axisIllness exposureHealthy controlsDepressive symptomsMDD groupLarger studyMRNA expressionMRNA levelsExpression levelsInflammationTNFChildrenDiagnosisBloodAdolescentsNR3C1M31 Gene Expression In Blood of Children And Adolescents: Influence of Environmental Stressors On Major Depressive Disorder
Spindola L, Pan P, Moretti P, Ota V, Santoro M, Cogo-Moreira H, Gadelha A, Salum G, Manfro G, Mari J, Brentani H, Grassi-Oliveira R, Brietzke E, Miguel E, Rohde L, Sato J, Bressan R, Belangero S. M31 Gene Expression In Blood of Children And Adolescents: Influence of Environmental Stressors On Major Depressive Disorder. European Neuropsychopharmacology 2017, 27: s387-s388. DOI: 10.1016/j.euroneuro.2016.09.422.Peer-Reviewed Original ResearchMajor depressive disorderBlood of childrenPrenatal alcoholDepressive disorderChildhood maltreatmentMDD diagnosisPt exposureRole of glucocorticoidsPeripheral mRNA expressionGene expressionTobacco exposureIllness exposureHealthy controlsIL1B expressionDepressive symptomsMDD groupLarger studyMRNA expressionWhole bloodDisordersBloodExpression levelsInflammationTNFChildren
2016
Serum copeptin in children exposed to maltreatment
Coelho R, Levandowski M, Mansur R, da Cunha G, Asevedo E, Zugman A, Salum G, Gadelha A, Pan P, Rizzo L, Manfro G, Mari J, Rohde L, Miguel E, Bressan R, Brietzke E, Grassi‐Oliveira R. Serum copeptin in children exposed to maltreatment. Psychiatry And Clinical Neurosciences 2016, 70: 434-441. PMID: 27278269, DOI: 10.1111/pcn.12412.Peer-Reviewed Original ResearchConceptsHistory of CMCopeptin levelsSerum copeptinChildhood maltreatmentChild Behavior ChecklistSerum copeptin levelsAdrenal axis activationSerum copeptin concentrationSevere childhood maltreatmentPromising new biomarkerCBCL total scoreEnzyme-linked immunosorbentExternalizing symptomsCopeptin concentrationsSerum levelsAxis activationPsychiatric morbidityPositive historyClinical InterviewCopeptinNew biomarkersHistory of abuseChild psychopathology symptomsSymptom severitySymptoms