2019
Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence?
de Araujo C, Swardfager W, Zugman A, Cogo-Moreira H, Belangero S, Ota V, Spindola L, Hakonarson H, Pellegrino R, Gadelha A, Salum G, Pan P, Mansur R, Hoexter M, Picon F, Sato J, Brietzke E, Grassi-Oliveira R, Rohde L, Miguel E, Bressan R, Jackowski A. Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence? CNS Spectrums 2019, 25: 790-796. PMID: 31845634, DOI: 10.1017/s1092852919001688.Peer-Reviewed Original ResearchConceptsSerum BDNF concentrationsBrain-derived neurotrophic factorBDNF concentrationsBDNF genotypeCortical thicknessPsychiatric disordersSerum brain-derived neurotrophic factor (BDNF) concentrationsBrain-derived neurotrophic factor concentrationSubcortical volumesMental disordersWell-Being Behavior AssessmentBrain structuresBDNF serum concentrationsNeurotrophic factor concentrationsPeripheral blood concentrationsHigh Risk Cohort StudyLate childhoodAdult psychiatric disordersLarge independent samplesCohort studyNeurotrophic factorCortical maturationSerum concentrationsBlood concentrationsMet carriers
2016
Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology
Mansur R, Cunha G, Asevedo E, Zugman A, Zeni-Graiff M, Rios A, Sethi S, Maurya P, Levandowski M, Gadelha A, Pan P, Stertz L, Belangero S, Anna M, Teixeira A, Mari J, Rohde L, Miguel E, McIntyre R, Grassi-Oliveira R, Bressan R, Brietzke E. Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology. PLOS ONE 2016, 11: e0160455. PMID: 27489945, PMCID: PMC4973983, DOI: 10.1371/journal.pone.0160455.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorThiobarbituric acid reactive substancesMental health problemsInterleukin-6Serum levelsHealth problemsSocioeconomic disadvantagePeripheral biomarkersSerum biomarkersOxidative stress markersAcid reactive substancesCross-sectional designChild Behavior Checklist DSMNeurotrophic factorHigher socioeconomic disadvantageSocio-demographic characteristicsBiomarker levelsNeurotrophic proteinsDomains of psychopathologyStress markersSpecific SubscaleCumulative risk modelBiomarkersMultiple biological systemsPathological neurodevelopment
2015
Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample
Cunha G, Asevedo E, Mansur R, Zugman A, Pan P, Gadelha A, Belangero S, Rizzo L, Coelho R, Stertz L, Cogo-Moreira H, Grassi-Oliveira R, Teixeira A, Kauer-Sant'Anna M, Mari J, Miguel E, Bressan R, Brietzke E. Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample. Acta Psychiatrica Scandinavica 2015, 133: 122-132. PMID: 26139469, DOI: 10.1111/acps.12453.Peer-Reviewed Original ResearchCluster of symptomsChild Behavior ChecklistPsychiatric diagnosisBrain-derived neurotrophic factorLarge community sampleImmune-inflammatory pathwaysEotaxin/CCL11CBCL total scoreWell-Being AssessmentCommunity sampleSchool-based studyIllness severityPeripheral biomarkersIL-6Neurotrophic factorPeripheral bloodMCP-1Older subjectsBehavioral symptomsMental disordersSignificant associationNeurodevelopmental psychopathologySymptomsSpecific disordersTotal score