2001
Regional Cerebral Blood Flow Abnormalities in Early-Onset Obsessive-Compulsive Disorder: An Exploratory SPECT Study
BUSATTO G, BUCHPIGUEL C, ZAMIGNANI D, GARRIDO G, GLABUS M, ROSARIO-CAMPOS M, CASTRO C, MAIA A, ROCHA E, MCGUIRE P, MIGUEL E. Regional Cerebral Blood Flow Abnormalities in Early-Onset Obsessive-Compulsive Disorder: An Exploratory SPECT Study. Journal Of The American Academy Of Child & Adolescent Psychiatry 2001, 40: 347-354. PMID: 11288777, DOI: 10.1097/00004583-200103000-00015.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderLate-onset subjectsOCD subjectsRegional cerebral blood flow (rCBF) single-photon emissionCerebral blood flow single photon emissionRegional cerebral blood flow abnormalitiesCerebral blood flow abnormalitiesObsessive-compulsive symptomsPathophysiology of OCDBlood flow abnormalitiesEarly-onset casesOnset obsessive-compulsive disorderFrontal-subcortical circuitsAge of onsetEarly-onset subjectsAnterior cingulate cortexPrefrontal cortex relativeSingle photon emissionStatistical parametric mappingRCBF differencesRight thalamusHealthy controlsFlow abnormalitiesClinical dataCortex relative
2000
A voxel-based investigation of regional cerebral blood flow abnormalities in obsessive–compulsive disorder using single photon emission computed tomography (SPECT)
Busatto G, Zamignani D, Buchpiguel C, Garrido G, Glabus M, Rocha E, Maia A, Rosario-Campos M, Castro C, Furuie S, Gutierrez M, McGuire P, Miguel E. A voxel-based investigation of regional cerebral blood flow abnormalities in obsessive–compulsive disorder using single photon emission computed tomography (SPECT). Psychiatry Research 2000, 99: 15-27. PMID: 10891646, DOI: 10.1016/s0925-4927(00)00050-0.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexECD uptakeObsessive-compulsive disorderCingulate cortexLateral orbitofrontal cortexObsessive-compulsive symptomsOrbitofrontal cortexControl subjectsOCD patientsLeft dorsal anterior cingulate cortexRegional cerebral blood flow abnormalitiesImaging studiesCerebral blood flow abnormalitiesRight medial orbitofrontal cortexPatient samplesRegional cerebral blood flowPathophysiology of OCDRight lateral orbitofrontal cortexRCBF SPECT studiesHealthy control subjectsBlood flow abnormalitiesCerebral blood flowLarger patient samplesSmall patient sampleLeft lateral orbitofrontal cortex