2024
Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure
Vriend C, de Joode N, Pouwels P, Liu F, Otaduy M, Pastorello B, Robertson F, Ipser J, Lee S, Hezel D, van Meter P, Batistuzzo M, Hoexter M, Sheshachala K, Narayanaswamy J, Venkatasubramanian G, Lochner C, Miguel E, Reddy Y, Shavitt R, Stein D, Wall M, Simpson H, van den Heuvel O. Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure. Molecular Psychiatry 2024, 29: 1033-1045. PMID: 38228890, PMCID: PMC11176057, DOI: 10.1038/s41380-023-02390-8.Peer-Reviewed Original ResearchObsessive-compulsive disorderPathophysiology of obsessive-compulsive disorderObsessive-compulsive disorder groupAge of OCD onsetOCD onsetHealthy controlsMedication-free adultsWhite matter microstructural alterationsVisual attention processesWhite matter microstructureStructural brain networksStructural connectome analysisWhite matter tractsBayesian multilevel analysisDirection of effectAttentional processesOCD individualsBrain signaturesBrain networksDiffusion MRI studiesPost hoc analysisSagittal stratumConnectome analysisMultilevel analysisStructural connectome
2023
Polygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample
Sato J, Biazoli C, Bueno A, Caye A, Pan P, Santoro M, Honorato‐Mauer J, Salum G, Hoexter M, Bressan R, Jackowski A, Miguel E, Belangero S, Rohde L. Polygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample. Genes Brain & Behavior 2023, 22: e12838. PMID: 36811275, PMCID: PMC10067387, DOI: 10.1111/gbb.12838.Peer-Reviewed Original ResearchConceptsCingulo-opercular networkDefault mode networkADHD-PRSAttentional networksFunctional segregationAttention-deficit/hyperactivity disorder (ADHD) symptomsAttention-deficit/hyperactivity disorderLarge-scale brain networksADHD polygenic risk scoresHyperactivity disorder symptomsSegregation of networksFunctional network segregationLongitudinal community-based cohortAttentional processesRs-fMRI dataExecutive functionHyperactivity disorderDisorder symptomsBrain networksCommunity-based sampleProbable ADHDADHDNetwork segregationPolygenic risk scoresDirection of association