2023
Gamma knife capsulotomy for intractable OCD: Neuroimage analysis of lesion size, location, and clinical response
McLaughlin N, Magnotti J, Banks G, Nanda P, Hoexter M, Lopes A, Batistuzzo M, Asaad W, Stewart C, Paulo D, Noren G, Greenberg B, Malloy P, Salloway S, Correia S, Pathak Y, Sheehan J, Marsland R, Gorgulho A, De Salles A, Miguel E, Rasmussen S, Sheth S. Gamma knife capsulotomy for intractable OCD: Neuroimage analysis of lesion size, location, and clinical response. Translational Psychiatry 2023, 13: 134. PMID: 37185805, PMCID: PMC10130137, DOI: 10.1038/s41398-023-02425-2.Peer-Reviewed Original ResearchConceptsY-BOCS reductionObsessive-compulsive disorderGamma knife capsulotomyLesion sizeRefractory obsessive-compulsive disorderOverall lesion volumeIntractable obsessive-compulsive disorderLesion-symptom mappingVoxel-wise lesion-symptom mappingClinical improvementClinical responseWhite matter pathwaysClinical outcomesFull respondersConventional therapyInternal capsuleLesion characteristicsLesion volumeAnterior limbEffective treatmentLesion locationLesion occurrenceCoronal planeSize/locationPatients
2021
Neurocircuitry of Deep Brain Stimulation for Obsessive-Compulsive Disorder as Revealed by Tractography: A Systematic Review
Vieira E, Arantes P, Hamani C, Iglesio R, Duarte K, Teixeira M, Miguel E, Lopes A, Godinho F. Neurocircuitry of Deep Brain Stimulation for Obsessive-Compulsive Disorder as Revealed by Tractography: A Systematic Review. Frontiers In Psychiatry 2021, 12: 680484. PMID: 34276448, PMCID: PMC8280498, DOI: 10.3389/fpsyt.2021.680484.Peer-Reviewed Original ResearchDeep brain stimulationObsessive-compulsive disorderBrain stimulationEffects of DBSMechanisms of DBSRefractory obsessive-compulsive disorderOCD patientsVentral anterior limbDifferent white matter pathwaysCorresponding clinical outcomesDiffusion-weighted imagingDifferent fiber tractsDiffusion tensor imagingPostoperative periodWhite matter pathwaysClinical outcomesInternal capsuleFavorable outcomeDBS effectsDTI-MRIAnterior limbAffective symptomsElectronic databasesWhite matterPatients
2020
Obsessive–Compulsive Personality Symptoms Predict Poorer Response to Gamma Ventral Capsulotomy for Intractable OCD
Copetti M, Lopes A, Requena G, Johnson I, Greenberg B, Noren G, McLaughlin N, Shavitt R, Miguel E, Batistuzzo M, Hoexter M. Obsessive–Compulsive Personality Symptoms Predict Poorer Response to Gamma Ventral Capsulotomy for Intractable OCD. Frontiers In Psychiatry 2020, 10: 936. PMID: 31998155, PMCID: PMC6962231, DOI: 10.3389/fpsyt.2019.00936.Peer-Reviewed Original ResearchGamma ventral capsulotomyPersonality disorder symptomsIntractable obsessive-compulsive disorderObsessive-compulsive disorderDisorder symptomsOCD patientsTreatment responseDisorder symptom changeSymptom changeStructured Clinical InterviewWorse treatment responseDSM-IV personality disordersWilcoxon signed-rank testPoorer ResponseClinical responseTreatment optionsInternal capsuleSigned-rank testTreatment attemptsAnterior limbClinical InterviewRadiosurgical proceduresPatientsSymptomsVentral part
2019
Understanding gamma ventral capsulotomy: Potential implications of diffusion tensor image tractography on target selectivity
de Oliveira Santos B, Gorgulho A, Saraiva C, Lopes A, Gomes J, Pássaro A, Hoexter M, Miguel E, De Salles A. Understanding gamma ventral capsulotomy: Potential implications of diffusion tensor image tractography on target selectivity. Surgical Neurology International 2019, 10: 136. PMID: 31528471, PMCID: PMC6744751, DOI: 10.25259/sni-65-2019.Peer-Reviewed Original ResearchDiffusion tensor image tractographyMorbid obesity patientsOCD patientsObesity patientsInternal capsuleOrbitofrontal cortexAnterior internal capsuleGamma ventral capsulotomyMedial orbitofrontal cortexFunctional stereotactic proceduresFunctional patientsMorbid obesityMean ageTract fibersAnterior limbCerebral hemispheresPatientsFiber tractsDisorder individualsStereotactic proceduresDeep brain stimulation implantsObesityTractography parametersExact topographyTractography
2015
Gamma knife surgery
Lopes A, Batistuzzo M, Gentil A, Hoexter M, Miguel E. Gamma knife surgery. 2015, 369-383. DOI: 10.1002/9781118801086.ch20.Peer-Reviewed Original ResearchSevere adverse eventsGamma Knife surgeryGamma knife radiosurgeryDeep brain stimulationAdverse eventsBrain cystsCase seriesDecreased incidenceObsessive-compulsive disorderSymptom improvementInternal capsuleKnife radiosurgeryAblative proceduresAnterior limbPsychiatric disordersBrain stimulationMajority of studiesRadiosurgical techniquesWhite matter tissueDisordersPatientsSurgeryLesionsRadiosurgeryIncidence
2014
Gamma Ventral Capsulotomy for Obsessive-Compulsive Disorder: A Randomized Clinical Trial
Lopes A, Greenberg B, Canteras M, Batistuzzo M, Hoexter M, Gentil A, Pereira C, Joaquim M, de Mathis M, D’Alcante C, Taub A, de Castro D, Tokeshi L, Sampaio L, Leite C, Shavitt R, Diniz J, Busatto G, Norén G, Rasmussen S, Miguel E. Gamma Ventral Capsulotomy for Obsessive-Compulsive Disorder: A Randomized Clinical Trial. JAMA Psychiatry 2014, 71: 1066-1076. PMID: 25054836, DOI: 10.1001/jamapsychiatry.2014.1193.Peer-Reviewed Original ResearchConceptsIntractable obsessive-compulsive disorderObsessive-compulsive disorderClinical trialsGamma ventral capsulotomyClinical Global Impressions-Improvement scaleSerious adverse eventsRandomized clinical trialsCGI-I ratingsDeep brain stimulationYale-Brown ObsessiveAdverse eventsMonth 12Additional patientsActive treatmentSham groupSymptom improvementInternal capsuleSpecialized centersNeurosurgical ablationAnterior limbMAIN OUTCOMEPsychiatric disordersPatientsOCD symptom improvementSelect cases
2009
Association between symptom severity and internal capsule volume in obsessive-compulsive disorder
de Souza Duran F, Hoexter M, Valente A, Miguel E, Busatto G. Association between symptom severity and internal capsule volume in obsessive-compulsive disorder. Neuroscience Letters 2009, 452: 68-71. PMID: 19150484, DOI: 10.1016/j.neulet.2009.01.007.Peer-Reviewed Original ResearchConceptsWhite matter volumeObsessive-compulsive disorderMagnetic resonance imagingMatter volumeCingulum bundleWhite matter volume deficitsPathophysiology of OCDOCD patientsAsymptomatic control subjectsWhite matter reductionThalamic-cortical circuitWhite matter alterationsVoxel-based morphometryWhite matter tractsRegional white matter volumeSymptom severity ratingsInternal capsuleNeurosurgical treatmentSeverity scoreControl subjectsAnterior limbConnectivity dysfunctionT MRI scannerOCD severity scoresVolume deficits