2024
Chapter 21 Gamma Knife for psychiatric indications
Lopes A, de Arruda I, Batistuzzo M, Gorgulho A, de Salles A, Miguel E. Chapter 21 Gamma Knife for psychiatric indications. 2024, 495-517. DOI: 10.1016/b978-0-443-18496-3.00021-5.Peer-Reviewed Original ResearchAnorexia nervosaObsessive-compulsive disorder patientsTreatment of psychiatric disordersAnterior limb of internal capsuleObsessive-compulsive disorderVentral anterior limbGamma KnifeGK radiosurgeryMajor depressionDisorder patientsPsychiatric disordersPsychiatric indicationsNervosaDepressionInternal capsuleSurgical modalitiesAdverse eventsDisordersAnorexiaRadiosurgeryWeight gainManiaPsychiatryBrain cystsComplications
2022
Management of Patients With Obsessive-Compulsive Disorder: Focus on Pharmacotherapy
Maziero M, Macaya D, Shavitt R, Diniz J, Miguel E, Silva R, Costa D. Management of Patients With Obsessive-Compulsive Disorder: Focus on Pharmacotherapy. Psychiatric Annals 2022, 52: 143-151. DOI: 10.3928/00485713-20220315-01.Peer-Reviewed Original ResearchSelective serotonin reuptake inhibitorsObsessive-compulsive disorderPharmacological treatmentFirst-line pharmacological therapySecond-line pharmacological treatmentPotential clinical situationsHalf of patientsManagement of patientsSerotonin reuptake inhibitorsKnowledge of cliniciansCommon clinical issueTreatment of patientsReports of RCTsTreatment of OCDAdverse eventsSSRI treatmentPharmacological therapyReuptake inhibitorsSignificant morbidityPharmacological strategiesLimited efficacyClinical practiceClinical situationsClinical issuesSocial disability
2021
Efficacy and safety of transcranial direct current stimulation as an add-on treatment for obsessive-compulsive disorder: a randomized, sham-controlled trial
Silva R, Brunoni A, Goerigk S, Batistuzzo M, Costa D, Diniz J, Padberg F, D’Urso G, Miguel E, Shavitt R. Efficacy and safety of transcranial direct current stimulation as an add-on treatment for obsessive-compulsive disorder: a randomized, sham-controlled trial. Neuropsychopharmacology 2021, 46: 1028-1034. PMID: 33452434, PMCID: PMC8115679, DOI: 10.1038/s41386-020-00928-w.Peer-Reviewed Original ResearchConceptsTreatment-resistant obsessive-compulsive disorderTranscranial direct current stimulationSupplementary motor areaBaseline Y-BOCS scoresActive transcranial direct current stimulationObsessive-compulsive disorderY-BOCS scoresDirect current stimulationAdverse eventsWeek 12Efficacy of tDCSCurrent stimulationCathodal transcranial direct current stimulationSham-controlled trialMild adverse eventsClinical Global ImpressionSham-controlled studyBetween-group differencesSymptoms of depressionSecondary outcomesPrimary outcomeImprovement subscaleGlobal ImpressionNeuromodulation therapiesTreatment resistance
2015
Gamma knife surgery
Lopes A, Batistuzzo M, Gentil A, Hoexter M, Miguel E. Gamma knife surgery. 2015, 369-383. DOI: 10.1002/9781118801086.ch20.Peer-Reviewed Original ResearchSevere adverse eventsGamma Knife surgeryGamma knife radiosurgeryDeep brain stimulationAdverse eventsBrain cystsCase seriesDecreased incidenceObsessive-compulsive disorderSymptom improvementInternal capsuleKnife radiosurgeryAblative proceduresAnterior limbPsychiatric disordersBrain stimulationMajority of studiesRadiosurgical techniquesWhite matter tissueDisordersPatientsSurgeryLesionsRadiosurgeryIncidence
2014
Gamma Ventral Capsulotomy for Obsessive-Compulsive Disorder: A Randomized Clinical Trial
Lopes A, Greenberg B, Canteras M, Batistuzzo M, Hoexter M, Gentil A, Pereira C, Joaquim M, de Mathis M, D’Alcante C, Taub A, de Castro D, Tokeshi L, Sampaio L, Leite C, Shavitt R, Diniz J, Busatto G, Norén G, Rasmussen S, Miguel E. Gamma Ventral Capsulotomy for Obsessive-Compulsive Disorder: A Randomized Clinical Trial. JAMA Psychiatry 2014, 71: 1066-1076. PMID: 25054836, DOI: 10.1001/jamapsychiatry.2014.1193.Peer-Reviewed Original ResearchConceptsIntractable obsessive-compulsive disorderObsessive-compulsive disorderClinical trialsGamma ventral capsulotomyClinical Global Impressions-Improvement scaleSerious adverse eventsRandomized clinical trialsCGI-I ratingsDeep brain stimulationYale-Brown ObsessiveAdverse eventsMonth 12Additional patientsActive treatmentSham groupSymptom improvementInternal capsuleSpecialized centersNeurosurgical ablationAnterior limbMAIN OUTCOMEPsychiatric disordersPatientsOCD symptom improvementSelect cases
2011
A Double-Blind, Randomized, Controlled Trial of Fluoxetine Plus Quetiapine or Clomipramine Versus Fluoxetine Plus Placebo for Obsessive-Compulsive Disorder
Diniz J, Shavitt R, Fossaluza V, Koran L, de Bragança Pereira C, Miguel E. A Double-Blind, Randomized, Controlled Trial of Fluoxetine Plus Quetiapine or Clomipramine Versus Fluoxetine Plus Placebo for Obsessive-Compulsive Disorder. Journal Of Clinical Psychopharmacology 2011, 31: 763-768. PMID: 22020357, DOI: 10.1097/jcp.0b013e3182367aee.Peer-Reviewed Original ResearchConceptsY-BOCS scoresFluoxetine groupTreatment regimenSelective serotonin reuptake inhibitorsPlacebo-controlled trialSevere adverse eventsSerotonin reuptake inhibitorsMain outcome measuresObsessive-compulsive disorder patientsCompulsive Scale scoresYale-Brown ObsessiveFluoxetine monotherapyAdverse eventsReuptake inhibitorsObsessive-compulsive disorderPrimary diagnosisOutcome measuresDisorder patientsScale scoreFluoxetineMental disordersQuetiapinePatientsStatistical ManualClomipramine
2009
Treatment of Resistant Obsessive-Compulsive Disorder With Ventral CapsularVentral Striatal Gamma Capsulotomy: A Pilot Prospective Study
Lopes A, Greenberg B, Norén G, Canteras M, Busatto G, de Mathis M, Taub A, D'Alcante C, Hoexter M, Gouvea F, Cecconi J, Gentil A, Ferrão Y, Fuentes D, de Castro C, Leite C, Salvajoli J, Duran F, Rasmussen S, Miguel E. Treatment of Resistant Obsessive-Compulsive Disorder With Ventral CapsularVentral Striatal Gamma Capsulotomy: A Pilot Prospective Study. Journal Of Neuropsychiatry 2009, 21: 381-392. PMID: 19996246, DOI: 10.1176/jnp.2009.21.4.381.Peer-Reviewed Original ResearchConceptsResistant obsessive-compulsive disorderRefractory OCD patientsAdverse effectsPilot prospective studyObsessive-compulsive disorder patientsAdverse eventsProspective studyObsessive-compulsive disorderStereotactic radiosurgeryDepressive symptomsDisorder patientsSide effectsConventional treatmentCapsulotomyTherapeutic promisePatientsOCD patientsTreatmentSurgeryRadiosurgerySymptomsMonths
2004
Atualização sobre o tratamento neurocirúrgico do transtorno obsessivo-compulsivo
Lopes A, de Mathis M, Canteras M, Salvajoli J, Del Porto J, Miguel E. Atualização sobre o tratamento neurocirúrgico do transtorno obsessivo-compulsivo. Brazilian Journal Of Psychiatry 2004, 26: 62-66. PMID: 15057843, DOI: 10.1590/s1516-44462004000100015.Peer-Reviewed Original ResearchConceptsDeep brain stimulationObsessive-compulsive disorderBrain stimulationOCD patientsSevere OCD patientsPost-operative improvementSevere psychosocial impairmentSevere psychiatric disordersActinic lesionsLimbic leucotomyMedial pallidotomyAdverse eventsAnterior capsulotomyAnterior cingulotomyTreatment trialsSurgical techniquePsychosocial impairmentSurgical proceduresLow prevalencePsychiatric disordersNeural circuitsStereotactic surgeryComplication issuesPersonality changesPatients