2023
Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part I: pharmacological treatment
de Oliveira M, de Barros P, de Mathis M, Boavista R, Chacon P, Echevarria M, Ferrão Y, de Queiroz Vattimo E, Lopes A, Torres A, Diniz J, Fontenelle L, do Rosário M, Shavitt R, Miguel E, da Silva R, da Conceição Costa D. Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part I: pharmacological treatment. Brazilian Journal Of Psychiatry 2023, 45: 146-161. PMID: 36749887, PMCID: PMC10154009, DOI: 10.47626/1516-4446-2022-2891.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsAdult obsessive-compulsive disorderObsessive-compulsive disorderPharmacological treatmentReuptake inhibitorsEvidence-based pharmacological interventionsFirst-line pharmacological treatmentAmerican Psychiatric Association guidelinesEvidence-based pharmacological treatmentFirst-line treatmentNorepinephrine reuptake inhibitorsPrimary outcome measureSerotonin reuptake inhibitorsGlutamate-modulating agentsHigh-quality evidenceAmerican Heart AssociationLevel of evidenceTreatment of OCDBrazilian Research ConsortiumAdult patientsHeart AssociationTolerable dosesAssociation guidelinesTreatment recommendationsPharmacological interventionsBrazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part II: cognitive-behavioral therapy
de Mathis M, Chacon P, Boavista R, de Oliveira M, de Barros P, Echevarria M, Ferrão Y, de Queiroz Vattimo E, Lopes A, Torres A, Diniz J, Fontenelle L, do Rosário M, Shavitt R, da Silva R, Miguel E, da Conceição Costa D. Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part II: cognitive-behavioral therapy. Brazilian Journal Of Psychiatry 2023, 45: 431-447. PMID: 37718254, PMCID: PMC10894635, DOI: 10.47626/1516-4446-2023-3081.Peer-Reviewed Original ResearchAdult obsessive-compulsive disorderObsessive-compulsive disorderTherapy treatmentHigh-quality scientific evidenceTreatment of adultsPrimary outcome measureHigh-quality evidenceAmerican Heart AssociationLevel of evidenceInternet-delivered CBTCognitive behavioral therapy treatmentBrazilian Research ConsortiumAdult patientsHeart AssociationClinical guidelinesTreatment recommendationsOutcome measuresAmerican CollegeSystematic reviewCBT interventionClinical interventionsCBT treatmentStudy designCBT protocolResponse prevention
2022
Right Prefrontal Cortical Thickness Is Associated With Response to Cognitive-Behavioral Therapy in Children With Obsessive-Compulsive Disorder
Bertolín S, Alonso P, Martínez-Zalacaín I, Menchón J, Jimenez-Murcia S, Baker J, Bargalló N, Batistuzzo M, Boedhoe P, Brennan B, Feusner J, Fitzgerald K, Fontaine M, Hansen B, Hirano Y, Hoexter M, Huyser C, Jahanshad N, Jaspers-Fayer F, Kuno M, Kvale G, Lazaro L, Machado-Sousa M, Marsh R, Morgado P, Nakagawa A, Norman L, Nurmi E, O’Neill J, Ortiz A, Perriello C, Piacentini J, Picó-Pérez M, Shavitt R, Shimizu E, Simpson H, Stewart S, Thomopoulos S, Thorsen A, Walitza S, Wolters L, Group E, Real E, Segalas C, Morer A, Brem S, Ferreira S, Moreira P, Hagen K, Hamatani S, Takahashi J, Yoshida T, de Mathis M, Miguel E, Pariente J, Tang J, Thompson P, van den Heuvel O, Stein D, Soriano-Mas C. Right Prefrontal Cortical Thickness Is Associated With Response to Cognitive-Behavioral Therapy in Children With Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 62: 403-414. PMID: 36526161, PMCID: PMC10065927, DOI: 10.1016/j.jaac.2022.07.865.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyObsessive-compulsive disorderCBT responseCortical thicknessMagnetic Resonance Imaging PredictorsBaseline cortical thicknessPrefrontal cortex thicknessFirst-line treatmentRostral middle frontal gyrusPrefrontal cortical thicknessIdentification of predictorsHigher cortical thicknessMiddle frontal gyrusRight prefrontal cortexCortical surface areaMechanism of actionAdult patientsImaging predictorsPrefrontal cortex regionsClinical managementLarge seriesSubcortical volumesAdult populationFrontal polePrefrontal cortexAssociation between chemosensory impairment with neuropsychiatric morbidity in post-acute COVID-19 syndrome: results from a multidisciplinary cohort study
Damiano R, Neto D, Oliveira J, Magalhães Santos J, Alves J, Guedes B, Nitrini R, de Araújo A, Oliveira M, Brunoni A, Voegels R, Bento R, Busatto G, Miguel E, Forlenza O, de Rezende Pinna F. Association between chemosensory impairment with neuropsychiatric morbidity in post-acute COVID-19 syndrome: results from a multidisciplinary cohort study. European Archives Of Psychiatry And Clinical Neuroscience 2022, 273: 325-333. PMID: 35633395, PMCID: PMC9142732, DOI: 10.1007/s00406-022-01427-3.Peer-Reviewed Original ResearchConceptsCohort studyChemosensory impairmentPost-acute COVID-19 syndromeCOVID-19 syndromeCentral nervous systemCOVID-19SARS-CoV-2Word list memory taskEpisodic memory impairmentSmell functionAdult patientsChemosensory dysfunctionAcute phaseNeuropsychiatric symptomsNeuropsychiatric morbidityGustatory lossHospitalization dataNeuropsychiatric impairmentEligible individualsSevere formCognition dysfunctionNervous systemMemory impairmentMultivariate analysisNeuropsychiatric disorders
2020
Higher volumes of hippocampal subfields in pediatric obsessive-compulsive disorder
Vattimo E, Dos Santos A, Hoexter M, Frudit P, Miguel E, Shavitt R, Batistuzzo M. Higher volumes of hippocampal subfields in pediatric obsessive-compulsive disorder. Psychiatry Research Neuroimaging 2020, 307: 111200. PMID: 33059948, DOI: 10.1016/j.pscychresns.2020.111200.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderHippocampal volumeTotal gray matter volumeRight whole hippocampusBilateral hippocampal headsLarger hippocampal volumesGray matter volumePediatric obsessive-compulsive disorderRight parasubiculumAdult patientsPediatric patientsHippocampal bodyAnatomic subregionsHippocampal headLimbic structuresHealthy controlsFreeSurfer softwareHippocampus volumeHippocampal subfieldsWhole hippocampusHippocampal cytoarchitectureEarly markerMatter volumePatientsSignificant larger volumes
2019
The impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects
Blanco‐Vieira T, Santos M, Ferrão YA, Torres AR, Miguel EC, Bloch MH, Leckman JF, do Rosario MC. The impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects. Depression And Anxiety 2019, 36: 533-542. PMID: 30990937, DOI: 10.1002/da.22898.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderAdult OCD patientsObsessive-compulsive disorderDeficit hyperactivity disorderOCD patientsClinical characteristicsExact testFeatures of ADHDHyperactivity disorderSubgroup of patientsAdult obsessive-compulsive disorderComorbid attention deficit hyperactivity disorderSpecific clinical featuresCross-sectional studyObsessive-compulsive disorder (OCD) subjectsLogistic regression analysisFisher's exact testBrazilian Research ConsortiumMann-Whitney testAdult patientsRheumatic feverDevelopment of interventionsClinical featuresObsessive-compulsive spectrum disordersLifetime prevalence
2017
Comorbidity, age of onset and suicidality in obsessive–compulsive disorder (OCD): An international collaboration
Brakoulias V, Starcevic V, Belloch A, Brown C, Ferrao Y, Fontenelle L, Lochner C, Marazziti D, Matsunaga H, Miguel E, Reddy Y, do Rosario M, Shavitt R, Sundar A, Stein D, Torres A, Viswasam K. Comorbidity, age of onset and suicidality in obsessive–compulsive disorder (OCD): An international collaboration. Comprehensive Psychiatry 2017, 76: 79-86. PMID: 28433854, DOI: 10.1016/j.comppsych.2017.04.002.Peer-Reviewed Original ResearchConceptsAge of onsetObsessive-compulsive disorderMajor depressive disorderComorbid disordersPsychiatric comorbidityAnxiety disordersSpecific phobiaDepressive disorderMajor depressionSuicidal ideationCo-occurring major depressive disorderLifetime psychiatric comorbiditySocial phobiaCurrent comorbid disordersPatterns of comorbidityComorbid major depressionPrimary obsessive-compulsive disorderDisorder treatment centersEarly ageBody dysmorphic disorderAdult patientsObsessive-compulsive personality disorderPsychiatric diagnostic classificationClinical variablesOCD comorbidity
2016
Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis
Boedhoe PS, Schmaal L, Abe Y, Ameis SH, Arnold PD, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Calvo A, Cheng Y, Cho KI, Dallaspezia S, Denys D, Fitzgerald KD, Fouche JP, Giménez M, Gruner P, Hanna GL, Hibar DP, Hoexter MQ, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Koch K, Kwon JS, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Nakamae T, Nakao T, Narayanaswamy JC, Piras F, Piras F, Pittenger C, Reddy YC, Sato JR, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin DF, Venkatasubramanian G, Walitza S, Wang Z, van Wingen GA, Xu J, Xu X, Yun JY, Zhao Q, Thompson P, Stein D, van den Heuvel O, Abe Y, Alonso P, Ameis S, Arnold P, Bargalló N, Batistuzzo M, Benedetti F, Beucke J, Boedhoe P, Bollettini I, Bose A, Brem S, Busatto G, Calvo A, Calvo R, Cath D, Cheng Y, Cho K, Dallaspezia S, de Vries F, de Wit S, Denys D, Fang Y, Fitzgerald K, Fontaine M, Fouche J, Giménez M, Gruner P, Hanna G, Hibar D, Hoexter M, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Khadka S, Koch K, Kwon J, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón J, Miguel E, Minuzzii L, Morer A, Nakamae T, Nakao T, Narayanaswamy J, Piras F, Piras F, Pittenger C, Reddy Y, Sato J, Simpson H, Schmaal L, Soreni N, Soriano-Mas C, Spalletta G, Stein D, Stevens M, Szeszko P, Thompson P, Tolin D, Veltman D, Venkatasubramanian G, van den Heuvel O, van der Werf Y, van Wingen G, Walitza S, Wang Z, Xu J, Xu X, Yun J, Zhao Q. Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis. American Journal Of Psychiatry 2016, 174: 60-69. PMID: 27609241, PMCID: PMC5344782, DOI: 10.1176/appi.ajp.2016.16020201.Peer-Reviewed Original ResearchConceptsAdult obsessive-compulsive disorderObsessive-compulsive disorderOCD patientsLarger thalamic volumesSubcortical volume alterationsSmaller hippocampal volumesAdult OCD patientsPediatric obsessive-compulsive disorderPotential modulating effectSubcortical brain volumesLimited statistical powerPallidum volumeClinical characteristicsAdult patientsPediatric patientsMean ageThalamic volumeControl subjectsPediatric controlsSubcortical abnormalitiesIllness profileHippocampal volumeHealthy subjectsNeurodevelopmental alterationsPatients
2015
Separation anxiety disorder in adult patients with obsessive-compulsive disorder: Prevalence and clinical correlates
Franz A, Rateke L, Hartmann T, McLaughlin N, Torres A, do Rosário M, Filho E, Ferrão Y. Separation anxiety disorder in adult patients with obsessive-compulsive disorder: Prevalence and clinical correlates. European Psychiatry 2015, 30: 145-151. PMID: 24908152, DOI: 10.1016/j.eurpsy.2014.04.007.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSeparation anxiety disorderPsychiatric comorbidityAnxiety disordersMore psychiatric comorbiditiesCross-sectional studyMultiple logistic regressionSpecific psychiatric comorbiditiesPrimary obsessive-compulsive disorderBrazilian Research ConsortiumSensory phenomenaGroup patientsAdult patientsHigh morbidityClinical correlatesSymptom assessmentPoor responsePrognostic evaluationLifetime diagnosisPatientsSuch symptomsSocio-demographic variablesLogistic regressionOCD patientsDisorders
2013
Clinical features of pure obsessive-compulsive disorder
Torres A, Shavitt R, Torresan R, Ferrão Y, Miguel E, Fontenelle L. Clinical features of pure obsessive-compulsive disorder. Comprehensive Psychiatry 2013, 54: 1042-1052. PMID: 23746710, DOI: 10.1016/j.comppsych.2013.04.013.Peer-Reviewed Original ResearchConceptsPure obsessive-compulsive disorderNon-comorbid patientsObsessive-compulsive disorderYale-Brown ObsessiveClinical characteristicsDSM-IV Axis I DisordersSuicidal thoughtsLogistic regressionCompulsive ScaleOCD patientsAnxious symptomsAxis I comorbidityCross-sectional studyAxis I DisordersStructured Clinical InterviewCo-occurring disordersPrevious suicidal thoughtsBrazilian Research ConsortiumLarge multicenter samplePure OCD patientsAdult patientsClinical featuresLifetime comorbidityPsychiatric comorbidityObsessive-compulsive spectrum disordersSymptom dimensions are associated with age of onset and clinical course of obsessive–compulsive disorder
Kichuk SA, Torres AR, Fontenelle LF, Rosário MC, Shavitt RG, Miguel EC, Pittenger C, Bloch MH. Symptom dimensions are associated with age of onset and clinical course of obsessive–compulsive disorder. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2013, 44: 233-239. PMID: 23410525, PMCID: PMC3654083, DOI: 10.1016/j.pnpbp.2013.02.003.Peer-Reviewed Original ResearchConceptsAge of onsetClinical courseObsessive-compulsive disorderPrimary symptom dimensionsSymptom dimensionsPrimary OCD symptomsChi-square testEarly ageOCD symptom dimensionsYale-Brown ObsessiveAdult patientsComorbid ticsSignificant symptomsLarge cohortDifferent OCD symptom dimensionsHeterogeneous symptomsSymptomsCompulsive ScaleDimensional Yale-Brown ObsessiveAgeSignificant differencesOCD symptomsOnsetInconsistent results
2012
Does anti-obsessional pharmacotherapy treat so-called comorbid depressive and anxiety states?
Valerio C, Diniz J, Fossaluza V, de Mathis M, Belotto-Silva C, Joaquim M, Filho E, Shavitt R. Does anti-obsessional pharmacotherapy treat so-called comorbid depressive and anxiety states? Journal Of Affective Disorders 2012, 139: 187-192. PMID: 22455835, DOI: 10.1016/j.jad.2012.02.002.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderPsychiatric comorbidityTreatment responseOCD treatment responseTic disordersOCD treatmentAnxiety disordersOCD patientsNon-blinded studyAdditional psychiatric disordersCertain comorbid disordersPrimary obsessive-compulsive disorderCommon comorbiditiesAdult patientsComorbid conditionsComorbid depressiveChronic conditionsMajor depressionTreatment protocolComorbiditiesComorbid disordersPsychiatric disordersDisorders ProgramConventional treatmentPossible association
2006
Clinical features associated with treatment response in obsessive-compulsive disorder
Shavitt R, Belotto C, Curi M, Hounie A, Rosário-Campos M, Diniz J, Ferrão Y, Pato M, Miguel E. Clinical features associated with treatment response in obsessive-compulsive disorder. Comprehensive Psychiatry 2006, 47: 276-281. PMID: 16769302, DOI: 10.1016/j.comppsych.2005.09.001.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderClinical featuresPharmacological treatmentTreatment responseEarly onsetConsecutive adult patientsFourth Edition criteriaSensory phenomenaEarly-onset obsessive-compulsive disorderYale-Brown ObsessiveOral clomipramineClomipramine treatmentAdult patientsPoor prognosisPoor responseSao Paulo SchoolDisorders ClinicTic disordersEdition criteriaScore decreaseFavorable responseLinear regression analysisMental disordersStatistical ManualDisorders