2016
Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis*
Yu J, Yun H, Shin B, Kim Y, Park E, Choi S, Yu J, Amarasekara D, Kim S, Inoue J, Walsh M, Choi Y, Takami M, Rho J. Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis*. Journal Of Biological Chemistry 2016, 291: 20643-20660. PMID: 27507811, PMCID: PMC5034056, DOI: 10.1074/jbc.m116.728303.Peer-Reviewed Original ResearchConceptsTNF receptor-associated factor 6Signaling complexIVVY motifCross-talkDbl homology domainCoiled-coil domainFactor 6RANK-mediated osteoclastogenesisTRAF6-binding siteFunctional cross-talkUbiquitin pathwayBinding partnersCytoplasmic tailTumor necrosis factor receptor-associated factor 6Activation of nuclear factor-kBInteraction partnersNuclear factor-kBProteomic approachVav3Signaling cascadesFunctional importanceMotifCooperative signalingMutantsInteraction of tumor necrosis factor receptor-associated factor 6
2007
Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene
Park E, Choi S, Kim J, Jeong Y, Choe J, Park C, Choi Y, Rho J. Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene. Biochemical And Biophysical Research Communications 2007, 363: 971-977. PMID: 17927961, DOI: 10.1016/j.bbrc.2007.09.103.Peer-Reviewed Original ResearchConceptsTumor necrosis factor receptor (TNFR)-associated factorsTRAF-interacting proteinCylindromatosis tumor suppressor geneFamilial cylindromatosis tumour suppressor geneHomozygous mouse embryosComplex in vitroEarly embryonic lethalityTumor suppressor geneExcessive cell deathNF-kappaB signalingAdaptor moleculeEmbryonic lethalityProliferation defectEmbryonic development in vivoSignaling in vitroSuppressor geneSignaling cascadesCell deathActivity in vitroDevelopment in vivoTargeted disruptionNF-kappaB activation in vitroFunctional roleCell proliferationMouse embryos