2024
Native architecture of a human GBP1 defense complex for cell-autonomous immunity to infection
Zhu S, Bradfield C, Maminska A, Park E, Kim B, Kumar P, Huang S, Kim M, Zhang Y, Bewersdorf J, MacMicking J. Native architecture of a human GBP1 defense complex for cell-autonomous immunity to infection. Science 2024, 383: eabm9903. PMID: 38422126, DOI: 10.1126/science.abm9903.Peer-Reviewed Original ResearchConceptsGuanylate-binding proteinsCaspase-4Surface of Gram-negative bacteriaGuanosine triphosphate hydrolysisImmunity to infectionInnate immunity to infectionCryo-electron tomographyGram-negative bacteriaImmunity proteinSignaling platformsMembrane insertionHuman cellsNative structureCombat infectionsLipopolysaccharide releaseGasdermin DExtended conformationLiving organismsProteinDefense complexCellsNative architectureGBP1BacteriaInfection
2014
Development of transgenic mouse model expressing porcine aminopeptidase N and its susceptibility to porcine epidemic diarrhea virus
Park J, Park E, Yu J, Rho J, Paudel S, Hyun B, Yang D, Shin H. Development of transgenic mouse model expressing porcine aminopeptidase N and its susceptibility to porcine epidemic diarrhea virus. Virus Research 2014, 197: 108-115. PMID: 25550073, PMCID: PMC7114392, DOI: 10.1016/j.virusres.2014.12.024.Peer-Reviewed Original ResearchConceptsSusceptible to porcine epidemic diarrhea virusPorcine epidemic diarrhea virusDiarrhea virusPorcine coronavirusPorcine APNLaboratory animal modelsPorcine aminopeptidase NPorcineAminopeptidase NCoronavirus infectionRespiratory diseaseTransgenic miceAnimal modelsCoronavirus studiesVirusPigsMiceInfectionTransgeneSusceptibility