2021
Tick host immunity: vector immunomodulation and acquired tick resistance
Kitsou C, Fikrig E, Pal U. Tick host immunity: vector immunomodulation and acquired tick resistance. Trends In Immunology 2021, 42: 554-574. PMID: 34074602, PMCID: PMC10089699, DOI: 10.1016/j.it.2021.05.005.Peer-Reviewed Original ResearchConceptsTick-host associationsTick resistanceImmune evasion activitiesNovel preventive strategiesImmunological eventsImmunomodulatory rolePreventive strategiesTick salivaIncidental hostsNew seedsPathogen transmissionBlood mealNatural hostVector competenceNatural persistenceCritical appraisalTicksAssociation
2019
Aedes aegypti NeSt1 Protein Enhances Zika Virus Pathogenesis by Activating Neutrophils
Hastings AK, Uraki R, Gaitsch H, Dhaliwal K, Stanley S, Sproch H, Williamson E, MacNeil T, Marin-Lopez A, Hwang J, Wang Y, Grover JR, Fikrig E. Aedes aegypti NeSt1 Protein Enhances Zika Virus Pathogenesis by Activating Neutrophils. Journal Of Virology 2019, 93: 10.1128/jvi.00395-19. PMID: 30971475, PMCID: PMC6580965, DOI: 10.1128/jvi.00395-19.Peer-Reviewed Original ResearchConceptsVirus infectionBite siteMosquito salivaImmune cellsZika virusLocal immune environmentMosquito bite siteZika virus pathogenesisEarly viral replicationZika virus infectionFactor 1Pathogenesis of flavivirusesVirus-infected mosquitoesVirus-induced pathogenesisCXCL2 expressionImmune environmentPassive immunizationZIKV pathogenesisImmune microenvironmentAntibody responseZIKV replicationVirus pathogenesisMosquito bitesPrimary mouse neutrophilsImmune system
2018
Vector Immunity and Evolutionary Ecology: The Harmonious Dissonance
Shaw DK, Tate AT, Schneider DS, Levashina EA, Kagan JC, Pal U, Fikrig E, Pedra JHF. Vector Immunity and Evolutionary Ecology: The Harmonious Dissonance. Trends In Immunology 2018, 39: 862-873. PMID: 30301592, PMCID: PMC6218297, DOI: 10.1016/j.it.2018.09.003.Peer-Reviewed Original ResearchConceptsVector immunityEvolutionary ecologyEvolutionary forcesEvolutionary ecologistsGenetic plasticityVector-borne pathogensArthropod populationsAbiotic factorsMolecular immunologistsMicrobial assaultImmune systemInnate defenseRecent scientific breakthroughsEcologyEcologistsImmune responsePathogenicityImmunityPathogensPlasticityDefenseToleranceResistanceScientific breakthroughs
2011
Identification and Characterization of Ixodes scapularis Antigens That Elicit Tick Immunity Using Yeast Surface Display
Schuijt TJ, Narasimhan S, Daffre S, DePonte K, Hovius JW, Veer C, van der Poll T, Bakhtiari K, Meijers JC, Boder ET, van Dam AP, Fikrig E. Identification and Characterization of Ixodes scapularis Antigens That Elicit Tick Immunity Using Yeast Surface Display. PLOS ONE 2011, 6: e15926. PMID: 21246036, PMCID: PMC3016337, DOI: 10.1371/journal.pone.0015926.Peer-Reviewed Original ResearchConceptsSalivary antigensTick salivary antigensPotential vaccine candidatesAnti-coagulant activityTick biteImmunization studiesVaccine candidatesAnti-complement activityTick antigensRepeated exposureTick immunityAntigenRabbit serumHall markTicks resultsImmunitySerumYeast surface display libraryRabbitsDisplay libraryIxodes scapularisDrosophila expression systemP19Surface display libraryP8
2008
RNA interference screen for human genes associated with West Nile virus infection
Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, Xavier RJ, Agaisse H, Fikrig E. RNA interference screen for human genes associated with West Nile virus infection. Nature 2008, 455: 242-245. PMID: 18690214, PMCID: PMC3136529, DOI: 10.1038/nature07207.Peer-Reviewed Original ResearchMeSH KeywordsComputational BiologyDengue VirusEndoplasmic ReticulumGene Expression ProfilingGenome, HumanHeLa CellsHIVHumansImmunityMonocarboxylic Acid TransportersMuscle ProteinsProtein BindingRNA InterferenceUbiquitinationUbiquitin-Protein LigasesVesiculovirusVirus ReplicationWest Nile FeverWest Nile virus
2003
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: A critical role of STAT3 in innate immunity
Welte T, Zhang SS, Wang T, Zhang Z, Hesslein DG, Yin Z, Kano A, Iwamoto Y, Li E, Craft JE, Bothwell AL, Fikrig E, Koni PA, Flavell RA, Fu XY. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: A critical role of STAT3 in innate immunity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 1879-1884. PMID: 12571365, PMCID: PMC149927, DOI: 10.1073/pnas.0237137100.Peer-Reviewed Original ResearchConceptsDeletion of Stat3STAT3 deletionInnate immune responseKey transcriptional mediatorNormal embryonic developmentCell-autonomous proliferationAbsence of STAT3Tissue-specific disruptionImmune responseInnate immunityCritical roleTumor necrosis factor alphaNF-kappa B activationTranscriptional mediatorsEmbryonic developmentBowel wall thickeningHematopoiesis resultsInflammatory cell infiltrationSignal transducerNecrosis factor alphaTranscription 3NAPDH oxidase activityBone marrow cellsMyeloid lineageSTAT3