2018
Circadian Rhythms Influence the Severity of Sepsis in Mice via a TLR2-Dependent, Leukocyte-Intrinsic Mechanism
Heipertz EL, Harper J, Lopez CA, Fikrig E, Hughes ME, Walker WE. Circadian Rhythms Influence the Severity of Sepsis in Mice via a TLR2-Dependent, Leukocyte-Intrinsic Mechanism. The Journal Of Immunology 2018, 201: ji1701677. PMID: 29760192, PMCID: PMC9351006, DOI: 10.4049/jimmunol.1701677.Peer-Reviewed Original ResearchConceptsImmune cellsZT 19C57BL/6 miceWorse outcomesTLR2 agonist lipoteichoic acidCircadian rhythmTLR2 knockout miceFemale C57BL/6 miceMale C57BL/6 miceSeverity of sepsisBone marrow chimerasTLR2-dependent mechanismIL-6 productionTLR2-DependentSepsis severityCecal ligationSepsis phenotypesSepsisC57BL/6 cellsSimilar outcomesMiceMouse cecumLipoteichoic acidMurine macrophagesCLP
2012
Immunity's fourth dimension: approaching the circadian–immune connection
Arjona A, Silver AC, Walker WE, Fikrig E. Immunity's fourth dimension: approaching the circadian–immune connection. Trends In Immunology 2012, 33: 607-612. PMID: 23000010, PMCID: PMC3712756, DOI: 10.1016/j.it.2012.08.007.Peer-Reviewed Original Research
2011
Circadian expression of clock genes in mouse macrophages, dendritic cells, and B cells
Silver AC, Arjona A, Hughes ME, Nitabach MN, Fikrig E. Circadian expression of clock genes in mouse macrophages, dendritic cells, and B cells. Brain Behavior And Immunity 2011, 26: 407-413. PMID: 22019350, PMCID: PMC3336152, DOI: 10.1016/j.bbi.2011.10.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsARNTL Transcription FactorsB-LymphocytesCircadian RhythmCircadian Rhythm Signaling Peptides and ProteinsCLOCK ProteinsDendritic CellsDNA-Binding ProteinsGene ExpressionMacrophagesMiceNuclear Receptor Subfamily 1, Group D, Member 1Period Circadian ProteinsPhotoperiodSpleenTranscription FactorsConceptsMolecular clock mechanismClock genesClock mechanismGene expressionClock-controlled transcription factorsFunctional molecular clockAspects of physiologyConstant environmental conditionsMolecular clockTranscription factorsCircadian expressionB cellsEnvironmental conditionsLight-dark cycleMouse macrophagesDaily rhythmsGenesExpressionCellsDendritic cellsMurine spleenMammalsMacrophagesSplenic NK cellsImmune cells