1992
Borrelia burgdorferi strain 25015: characterization of outer surface protein A and vaccination against infection.
Fikrig E, Barthold SW, Persing DH, Sun X, Kantor FS, Flavell RA. Borrelia burgdorferi strain 25015: characterization of outer surface protein A and vaccination against infection. The Journal Of Immunology 1992, 148: 2256-60. PMID: 1545130, DOI: 10.4049/jimmunol.148.7.2256.Peer-Reviewed Original ResearchConceptsSurface protein AOuter surface protein ABorrelia burgdorferi strain N40Vaccination of miceB. burgdorferiImmunized miceVaccination experimentsIntradermal challengeVaccine candidatesCerebrospinal fluidMiceProtein AStrain N40VaccinationStrain 297OspA geneBurgdorferiOspACD16NeuroborreliosisPatientsInfection
1990
Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA
Fikrig E, Barthold S, Kantor F, Flavell R. Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA. Science 1990, 250: 553-556. PMID: 2237407, DOI: 10.1126/science.2237407.Peer-Reviewed Original ResearchConceptsRecombinant OspALyme borreliosisC3H/HeJ miceProtection of miceTick-borne illnessB. burgdorferi strain N40Recombinant OspA proteinSurface protein AOuter surface protein AHeJ miceLyme disease agentStrain N40Borrelia burgdorferiB. burgdorferiMiceOspABorreliosisOspA proteinBurgdorferiDisease agentsProtein AVaccineIllnessAntibodies