Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi
Ouyang Z, Narasimhan S, Neelakanta G, Kumar M, Pal U, Fikrig E, Norgard MV. Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi. BMC Microbiology 2012, 12: 44. PMID: 22443136, PMCID: PMC3320556, DOI: 10.1186/1471-2180-12-44.Peer-Reviewed Original ResearchConceptsRpoN-RpoS regulatory pathwayRpoN-RpoS pathwayExpression of rpoSEnzootic life cycleMammalian infectionRegulatory pathwaysTranscription of rpoSOuter membrane lipoproteinLife cycleB. burgdorferiKey environmental stimuliLyme disease pathogenesisDiverse nichesMembrane lipoproteinMammalian hostsTarget genesTranscription levelsMicrobial survivalLipoprotein geneRpoSOrganism adaptationInfectious cycleFed larvaeIntermolt larvaeSustained transcription