2009
Passage through Ixodes scapularis Ticks Enhances the Virulence of a Weakly Pathogenic Isolate of Borrelia burgdorferi
Adusumilli S, Booth CJ, Anguita J, Fikrig E. Passage through Ixodes scapularis Ticks Enhances the Virulence of a Weakly Pathogenic Isolate of Borrelia burgdorferi. Infection And Immunity 2009, 78: 138-144. PMID: 19822652, PMCID: PMC2798202, DOI: 10.1128/iai.00470-09.Peer-Reviewed Original ResearchConceptsIxodes scapularis ticksCommon tick-borne illnessScapularis ticksTick-borne illnessB. burgdorferi sensu strictoC3H miceBurgdorferi sensu strictoLyme diseaseMiceHigh expression levelsBorrelia burgdorferiB. burgdorferiTick engorgementExpression levelsSpirochetesDiseaseArray analysisSyringe inoculationBurgdorferiPathogenic isolatesIsolatesI. scapularisArthritisVirulencePathogenesis
2008
The Tick Salivary Protein Salp15 Inhibits the Killing of Serum-Sensitive Borrelia burgdorferi Sensu Lato Isolates
Schuijt TJ, Hovius JW, van Burgel ND, Ramamoorthi N, Fikrig E, van Dam AP. The Tick Salivary Protein Salp15 Inhibits the Killing of Serum-Sensitive Borrelia burgdorferi Sensu Lato Isolates. Infection And Immunity 2008, 76: 2888-2894. PMID: 18426890, PMCID: PMC2446733, DOI: 10.1128/iai.00232-08.Peer-Reviewed Original ResearchConceptsComplement-mediated killingBurgdorferi-specific antibodiesBorrelia burgdorferiStrong protective effectSerum-sensitive isolatesNormal human serumBorrelia burgdorferi sensu latoBurgdorferi sensu latoProtective effectMembrane attack complexTick salivaLyme diseaseBorrelia burgdorferi sensu lato isolatesComplement complexI. scapularis Salp15B. burgdorferiSalp15Attack complexBurgdorferiHuman serumKillingSpirochetesIxodes scapularisIsolatesTicks