2020
An Ixodes scapularis Protein Disulfide Isomerase Contributes to Borrelia burgdorferi Colonization of the Vector
Cao Y, Rosen C, Arora G, Gupta A, Booth CJ, Murfin KE, Cerny J, Lopez A, Chuang YM, Tang X, Pal U, Ring A, Narasimhan S, Fikrig E. An Ixodes scapularis Protein Disulfide Isomerase Contributes to Borrelia burgdorferi Colonization of the Vector. Infection And Immunity 2020, 88: 10.1128/iai.00426-20. PMID: 32928964, PMCID: PMC7671890, DOI: 10.1128/iai.00426-20.Peer-Reviewed Original ResearchConceptsTick gutTick bite siteVector-host interfaceAbility of spirochetesProtein disulfide isomerase A3Infected vertebrate hostsInflammatory responseBite siteLyme diseaseVertebrate hostsGutTick proteinsAdditional targetsMiceSpirochete life cycleSpirochete survivalArthropod vectorsSpirochetesRNA interferenceIllnessTicks
1998
Heat shock protein 70 of the agent of human granulocytic ehrlichiosis binds to Borrelia burgdorferi antibodies.
Ijdo J, Zhang Y, Anderson M, Goldberg D, Fikrig E. Heat shock protein 70 of the agent of human granulocytic ehrlichiosis binds to Borrelia burgdorferi antibodies. MSphere 1998, 5: 118-20. PMID: 9455892, PMCID: PMC121403, DOI: 10.1128/cdli.5.1.118-120.1998.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisEhrlichial antigenHSP-70Borrelia burgdorferi antibodiesSerologic test resultsHeat shock protein 70Shock protein 70Burgdorferi antibodiesPatient seraGranulocytic ehrlichiosisLyme diseaseFirst weekHeat shock proteinsLyme disease spirochetePrior exposureImmunoglobulin GProtein 70Immunoblot analysisAntigenShock proteinsSerumAntibodiesPatientsIllnessIgG
1993
Protective immunity in lyme borreliosis
Fikrig E, Kantor FS, Barthold SW, Flavell RA. Protective immunity in lyme borreliosis. Trends In Parasitology 1993, 9: 129-131. PMID: 15463734, DOI: 10.1016/0169-4758(93)90176-g.Peer-Reviewed Original ResearchLyme diseaseCommon vector-borne illnessLyme borreliosisVector-borne illnessInitial diagnosisProtective immunityLate diseaseMurine modelSpirochete Borrelia burgdorferiVaccine candidatesSurface antigenEarly infectionDiseaseBorrelia burgdorferiBorreliosisTherapyVaccineIllnessInfectionAntigenDiagnosisImmunity
1990
Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA
Fikrig E, Barthold S, Kantor F, Flavell R. Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA. Science 1990, 250: 553-556. PMID: 2237407, DOI: 10.1126/science.2237407.Peer-Reviewed Original ResearchConceptsRecombinant OspALyme borreliosisC3H/HeJ miceProtection of miceTick-borne illnessB. burgdorferi strain N40Recombinant OspA proteinSurface protein AOuter surface protein AHeJ miceLyme disease agentStrain N40Borrelia burgdorferiB. burgdorferiMiceOspABorreliosisOspA proteinBurgdorferiDisease agentsProtein AVaccineIllnessAntibodies
1989
Septic Shock and Acute Respiratory Distress Syndrome After Salpingitis Caused by Streptococcus pyogenes Group A
FIKRIG E, WORTHINGTON M, LEFKOWITZ L. Septic Shock and Acute Respiratory Distress Syndrome After Salpingitis Caused by Streptococcus pyogenes Group A. Southern Medical Journal 1989, 82: 634-635. PMID: 2655106, DOI: 10.1097/00007611-198905000-00024.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeRespiratory distress syndromeStreptococcus pyogenes group ADistress syndromeGroup AIntensive supportive therapySymptoms of sepsisOnset of illnessIntravascular coagulationRenal failureAcute salpingitisSeptic shockSupportive therapyBlood culturesSalpingitisSyndromeHypotensionLaparotomySepsisPatientsTherapyIllnessSymptomsWomen