1997
Borrelia burgdorferi genes selectively expressed in ticks and mammals
de Silva AM, Fikrig E. Borrelia burgdorferi genes selectively expressed in ticks and mammals. Trends In Parasitology 1997, 13: 267-270. PMID: 15275064, DOI: 10.1016/s0169-4758(97)01074-0.Peer-Reviewed Original ResearchLyme disease vaccineTick-borne infectionsDisease vaccineHuman trialsSpirochete Borrelia burgdorferiDifferent surface proteinsLyme diseaseBorrelia burgdorferiLyme disease bacteriumBorrelia burgdorferi genesDisease bacteriumSurface proteinsRecent studiesDifferential gene expressionLife styleGene expressionVaccineInfectionDisease
1995
Efficacy of Human Lyme Disease Vaccine Formulations in a Mouse Model
Telford SR, Kantor FS, Lobet Y, Barthold SW, Spielman A, Flavell RA, Fikrig E. Efficacy of Human Lyme Disease Vaccine Formulations in a Mouse Model. The Journal Of Infectious Diseases 1995, 171: 1368-1370. PMID: 7751719, DOI: 10.1093/infdis/171.5.1368.Peer-Reviewed Original ResearchConceptsMouse modelC3H/HeJ mouse modelLyme diseaseRecombinant outer surface protein APhase I human trialsPhase II trialSurface protein AUnvaccinated miceII trialVaccinated miceOuter surface protein AVaccine formulationsHuman trialsRecombinant OspAMiceBorrelia burgdorferiDiseaseTrialsMajor siteTrial sitesProtein ATicksImmunizationVaccineInfection