2023
Repeated Tick Infestations Impair Borrelia burgdorferi Transmission in a Non-Human Primate Model of Tick Feeding
Narasimhan S, Booth C, Philipp M, Fikrig E, Embers M. Repeated Tick Infestations Impair Borrelia burgdorferi Transmission in a Non-Human Primate Model of Tick Feeding. Pathogens 2023, 12: 132. PMID: 36678479, PMCID: PMC9861725, DOI: 10.3390/pathogens12010132.Peer-Reviewed Original ResearchNon-human primatesImmune responseLyme diseaseTick transmissionAnimal modelsGuinea pigsNon-human primate modelProtective immune responseTick feedingTick infestationRobust immune responseTick salivary antigensElicit immune responsesHuman Lyme diseaseClinical manifestationsHuman pathogensPrimate modelSalivary antigensNon-natural hostsVaccine targetsDiseaseVaccine discoveryTick resistanceBorreliaNatural host
2009
Late Manifestations of Lyme Borreliosis
Hovius J, van Dam A, Fikrig E. Late Manifestations of Lyme Borreliosis. 2009, 9-25. DOI: 10.1128/9781555815486.ch2.Peer-Reviewed Original ResearchLyme borreliosisObjective clinical manifestationsFrequent clinical signsB. burgdorferiB. burgdorferi infectionHost immune responseCommon vector-borne diseaseClinical manifestationsErythema migransAntibiotic treatmentClinical signsBurgdorferi infectionImmune responsePositive culturesLate manifestationTick-borne pathogensLyme diseaseBorreliosisBorrelia burgdorferiDiseaseCausative agentB. afzeliiB. gariniiInfected tissuesBurgdorferi