2017
Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells
Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA. Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature 2017, 546: 667-670. PMID: 28636595, PMCID: PMC5787375, DOI: 10.1038/nature22967.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosis Regulatory ProteinsCARD Signaling Adaptor ProteinsCaspase 1DEAD-box RNA HelicasesEpithelial CellsFemaleImmunity, InnateInflammasomesInterleukin-18Intestinal MucosaIntestinesIntracellular Signaling Peptides and ProteinsMaleMiceMice, Inbred C57BLPhosphate-Binding ProteinsPyroptosisReceptors, G-Protein-CoupledRNA, Double-StrandedRotavirusRotavirus Infections
2015
Frostbite Protection in Mice Expressing an Antifreeze Glycoprotein
Heisig M, Mattessich S, Rembisz A, Acar A, Shapiro M, Booth CJ, Neelakanta G, Fikrig E. Frostbite Protection in Mice Expressing an Antifreeze Glycoprotein. PLOS ONE 2015, 10: e0116562. PMID: 25714402, PMCID: PMC4340617, DOI: 10.1371/journal.pone.0116562.Peer-Reviewed Original ResearchConceptsAnti-freeze glycoproteinAnti-freeze proteinsTransgenic Drosophila modelReduced cell deathDiverse speciesMammalian cellsDrosophila modelCold stressIAFGPMammalian tissuesCold shockCell deathCold hardinessDiverse mechanismsTick hostsTransgenic mouse modelPrevents tissue damagePrevention of frostbiteCold temperaturesAntifreeze glycoproteinsTransgenic miceGlycoproteinNorthern latitudesProtective functionMouse model