2024
A nomogram combining neutrophil to lymphocyte ratio (NLR) and prognostic nutritional index (PNI) to predict distant metastasis in gastric cancer
Liu J, Sun R, Cai K, Xu Y, Yuan W. A nomogram combining neutrophil to lymphocyte ratio (NLR) and prognostic nutritional index (PNI) to predict distant metastasis in gastric cancer. Scientific Reports 2024, 14: 15391. PMID: 38965325, PMCID: PMC11224267, DOI: 10.1038/s41598-024-65307-7.Peer-Reviewed Original ResearchConceptsNeutrophil-to-lymphocyte ratioPrognostic nutritional indexPlatelet-to-lymphocyte ratioSystemic immune-inflammatory indexLymphocyte to monocyte ratioMultivariate logistic regression analysisDistant metastasisLogistic regression analysisLymphocyte ratioReceiver operating characteristicGastric cancerValidation cohortPredictive factorsRisk factors of distant metastasisDistant metastasis of gastric cancerNutritional indexImmune-inflammatory indexClinical practiceNomogram's predictive performanceDecision curve analysisGastric cancer patientsMetastasis of gastric cancerEfficient nomogramRegression analysisMonocyte ratioHyperbaric oxygen therapy ameliorates intestinal and systematic inflammation by modulating dysbiosis of the gut microbiota in Crohn’s disease
Li Y, Sun R, Lai C, Liu K, Yang H, Peng Z, Xu D, Huang F, Tang K, Peng Y, Liu X. Hyperbaric oxygen therapy ameliorates intestinal and systematic inflammation by modulating dysbiosis of the gut microbiota in Crohn’s disease. Journal Of Translational Medicine 2024, 22: 518. PMID: 38816750, PMCID: PMC11137967, DOI: 10.1186/s12967-024-05317-1.Peer-Reviewed Original ResearchConceptsGut microbiotaFecal microbiota transplantationHyperbaric oxygen therapyDysbiosis of gut microbiotaComposition of gut microbiotaC-reactive proteinCrohn's Disease Activity IndexRegulating gut microbiotaHost physiological conditionAbundance of EscherichiaDisease activity indexCrohn's diseaseClostridium XIVaModulating dysbiosisGene sequencesSystematic inflammationMicrobial diversityOxygen therapyPatients treated with hyperbaric oxygen therapyMicrobiotaColitis mouse modelLevels of C-reactive proteinMicrobiota transplantationSerum C-reactive proteinEffect of hyperbaric oxygen therapy
2023
Caprini risk assessment model combined with D-dimer to predict the occurrence of deep vein thrombosis and guide intervention after laparoscopic radical resection of colorectal cancer
Zhang W, Sun R, Hu X, Chen Z, Lai C. Caprini risk assessment model combined with D-dimer to predict the occurrence of deep vein thrombosis and guide intervention after laparoscopic radical resection of colorectal cancer. World Journal Of Surgical Oncology 2023, 21: 299. PMID: 37735407, PMCID: PMC10512522, DOI: 10.1186/s12957-023-03183-7.Peer-Reviewed Original ResearchConceptsCaprini risk assessment modelLow-molecular-weight heparinLaparoscopic radical resection of colorectal cancerResection of colorectal cancerRadical resection of colorectal cancerLaparoscopic radical resectionLMWH groupD-dimerDeep vein thrombosisCut-off valueVein thrombosisROC curveColorectal cancerIPC groupClinical data of patientsLow incidence of thrombosisOccurrence of deep vein thrombosisAccurate risk stratificationDecision curve analysisData of patientsColorectal cancer patientsIncidence of thrombosisIncidence of DVTMolecular weight heparinArea under the ROC curveGastrointestinal: A case of IgG4‐related disease involving intestinal tract and orbital cavity
Lai C, Sun R, Zhang W, Peng Y. Gastrointestinal: A case of IgG4‐related disease involving intestinal tract and orbital cavity. Journal Of Gastroenterology And Hepatology 2023, 38: 1865-1865. PMID: 37340618, DOI: 10.1111/jgh.16254.Peer-Reviewed Original Research
2022
Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis promotes tumorigenesis and oxaliplatin resistance in colorectal cancer
Li Y, Gan Y, Liu J, Li J, Zhou Z, Tian R, Sun R, Liu J, Xiao Q, Li Y, Lu P, Peng Y, Peng Y, Shu G, Yin G. Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis promotes tumorigenesis and oxaliplatin resistance in colorectal cancer. Signal Transduction And Targeted Therapy 2022, 7: 87. PMID: 35351858, PMCID: PMC8964798, DOI: 10.1038/s41392-022-00902-6.Peer-Reviewed Original ResearchConceptsOxaliplatin resistanceColorectal cancerTumor growthMEIS1 expressionCell sensitivity to oxaliplatinPreventing DNA damage repairCombination of oxaliplatinSurvival of CRC patientsTreatment of colorectal cancerSensitivity to oxaliplatinEZH2 inhibitor GSK126Suppressed tumor growthReverse oxaliplatin resistanceFrontline treatmentAcquired resistanceCRC patientsInhibitor GSK126OxaliplatinFEN1 expressionTherapeutic strategiesDNA damage repairELFN1-AS1Cell survivalMeis1Patients
2021
Lung microbiome alterations in NSCLC patients
Zheng L, Sun R, Zhu Y, Li Z, She X, Jian X, Yu F, Deng X, Sai B, Wang L, Zhou W, Wu M, Li G, Tang J, Jia W, Xiang J. Lung microbiome alterations in NSCLC patients. Scientific Reports 2021, 11: 11736. PMID: 34083661, PMCID: PMC8175694, DOI: 10.1038/s41598-021-91195-2.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerNon-small cell lung cancer patientsRare speciesOral taxaLung microbiotaDiverse array of microbesNon-cancer controlsLobectomy samplesArray of microbesGlobal microbial compositionAssociated with lung cancer progressionLung cancerLung microbiome compositionBronchoscopy samplesPseudomonas entomophilaMetagenomic sequencingBronchoalveolar lavageLactobacillus rossiaeBacteroides pyogenesMicrobiota dysbiosisMicrobial communitiesMicrobiome compositionPaenibacillus odoriferMicrobial compositionLung microbiota dysbiosis