Intra‐neural administration of fractalkine attenuates neuropathic pain‐related behaviour
Holmes FE, Arnott N, Vanderplank P, Kerr NC, Longbrake EE, Popovich PG, Imai T, Combadière C, Murphy PM, Wynick D. Intra‐neural administration of fractalkine attenuates neuropathic pain‐related behaviour. Journal Of Neurochemistry 2008, 106: 640-649. PMID: 18410510, PMCID: PMC2726982, DOI: 10.1111/j.1471-4159.2008.05419.x.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesicsAnimalsBehavior, AnimalChemokine CX3CL1CX3C Chemokine Receptor 1Disease Models, AnimalDose-Response Relationship, DrugGanglia, SpinalGene Expression RegulationMacrophagesMaleMiceMice, Inbred BALB CMice, KnockoutPain MeasurementPain ThresholdReaction TimeReceptors, ChemokineRNA, MessengerSciaticaSpinal CordTime FactorsConceptsDorsal root gangliaNeuropathic pain-related behaviorLumbar dorsal root gangliaBALB/c controlsDevelopment of allodyniaIntra-neural injectionSciatic nerve proximalNeuropathic pain statesNerve injury modelSciatic nerve axotomyPain-related behaviorsExpression of CX3CR1Site of injuryNumber of cytokinesNeuropathic painNerve axotomyPain statesNerve proximalRoot gangliaSciatic nerveInjury modelCX3CR1 mRNAFractalkine mRNAKnockout miceAxotomy