2016
Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer
Tung N, Lin NU, Kidd J, Allen BA, Singh N, Wenstrup RJ, Hartman AR, Winer EP, Garber JE. Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer. Journal Of Clinical Oncology 2016, 34: 1460-1468. PMID: 26976419, PMCID: PMC4872307, DOI: 10.1200/jco.2015.65.0747.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overBreast NeoplasmsFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGenes, BRCA1Genes, BRCA2Genetic Predisposition to DiseaseGenetic TestingGerm-Line MutationHigh-Throughput Nucleotide SequencingHumansJewsMiddle AgedNeoplasm StagingOvarian NeoplasmsPredictive Value of TestsPrevalenceProspective StudiesRetrospective StudiesRisk FactorsTriple Negative Breast NeoplasmsConceptsCancer predisposition genesTriple-negative breast cancerBreast cancer predisposition genesBreast cancerPredisposition genesGermline mutationsOvarian cancerNext-generation sequencingBRCA1/2 mutationsCancer susceptibility genesSingle cancer centerFamily cancer historyBreast/ovarian cancerOvarian cancer predisposition genesPredictors of mutationsSusceptibility genesSelect patientsSequential patientsAshkenazi Jewish ancestryCancer CenterCancer historyClinical managementFamily historyBreast/ovarian cancer susceptibility geneOvarian cancer susceptibility genes
2015
Molecular Phenotype of Breast Cancer According to Time Since Last Pregnancy in a Large Cohort of Young Women
Collins LC, Gelber S, Marotti JD, White S, Ruddy K, Brachtel EF, Schapira L, Come SE, Borges VF, Schedin P, Warner E, Wensley T, Tamimi RM, Winer EP, Partridge AH. Molecular Phenotype of Breast Cancer According to Time Since Last Pregnancy in a Large Cohort of Young Women. The Oncologist 2015, 20: 713-718. PMID: 26025931, PMCID: PMC4492229, DOI: 10.1634/theoncologist.2014-0412.Peer-Reviewed Original ResearchConceptsBreast cancer molecular phenotypesBreast cancerYoung womenFamily historyPregnancy-associated breast cancerMolecular phenotypesTumor histologic gradeBreast cancer riskBreast cancer phenotypeLast pregnancyParous womenProspective cohortCentral reviewHistologic gradeLike subtypeMolecular subtypesLarge cohortCancer riskPregnancyClinical practiceStudy questionnaireBiomarker expressionCancerTumor phenotypeWomen
2007
Genetic testing in young women with breast cancer: Results from a web-based survey
Shin J, Gelber S, Garber J, Rosenberg R, Przypyszny M, Winer E, Partridge A. Genetic testing in young women with breast cancer: Results from a web-based survey. Journal Of Clinical Oncology 2007, 25: 21093-21093. DOI: 10.1200/jco.2007.25.18_suppl.21093.Peer-Reviewed Original ResearchBreast cancerOvarian cancerFamily historyGenetic testingYoung womenWeb-based surveyYoung breast cancer survivorsTime of diagnosisBreast cancer survivorsHigh-risk populationMajority of womenFear of recurrenceQuality of lifeCross-sectional surveyLarge web-based surveyBreast cancer diagnosisCancer survivorsBRCA1/2 mutationsAge 40Baseline anxietyNumber of childrenFertility issuesCancerMultivariate modelSignificant financial relationship
2002
Pre-Counseling Education Materials for BRCA Testing: Does Tailoring Make a Difference?
Skinner CS, Schildkraut JM, Berry D, Calingaert B, Marcom PK, Sugarman J, Winer EP, Iglehart JD, Futreal PA, Rimer BK. Pre-Counseling Education Materials for BRCA Testing: Does Tailoring Make a Difference? Genetic Testing And Molecular Biomarkers 2002, 6: 93-105. PMID: 12215248, DOI: 10.1089/10906570260199348.Peer-Reviewed Original ResearchConceptsGenetic testingOvarian cancer susceptibilityTumor RegistryMean ageOvarian cancer gene BRCA1Ovarian cancerFamily historyMutation carriersBRCA testingBaseline surveyCancer susceptibilityEstimation of riskBehavioral targetsPrint materialsGreater improvementBreastFollowup surveyEducation materialsWomenGenes BRCA1Decision aidRiskBRCA1
1999
Modeling Risk of Breast Cancer and Decisions about Genetic Testing
Parmigiani G, Berry D, Iversen E, Müller P, Schildkraut J, Winer E. Modeling Risk of Breast Cancer and Decisions about Genetic Testing. Lecture Notes In Statistics 1999, 140: 133-203. DOI: 10.1007/978-1-4612-1502-8_3.Peer-Reviewed Original ResearchBreast cancerFamily historyGenetic susceptibilityGenetic testingPreventive treatment decisionsPatient counselingRisk factorsTreatment decisionsClinical OncologyRelated cancersBRCA2 genesCancerMedical decision makingIndividualized informationRiskAccurate assessmentPatientsDuke UniversityRisk communicationBreastCliniciansEpidemiologyResearch UnitSusceptibilityOncology
1998
Overestimation of Hereditary Breast Cancer Risk
Iglehart J, Miron A, Rimer B, Winer E, Berry D, Shildkraut J. Overestimation of Hereditary Breast Cancer Risk. Annals Of Surgery 1998, 228: 375-384. PMID: 9742920, PMCID: PMC1191495, DOI: 10.1097/00000658-199809000-00010.Peer-Reviewed Original ResearchConceptsOvarian cancerHereditary factorsBRCA2 mutationsHereditary breast cancer riskIntensive clinical servicesTest-negative womenExpert panelBreast cancer riskCarrier probabilitiesAffected womenFamily historyCancer riskHereditary riskCancerClinical servicesBreastWomenHigher risk perceptionPretest educationWomen's perceptionsPersonal historyRiskBRCA1Disease-associated mutationsBRCA2Sequence analysis of BRCA1 and BRCA2: correlation of mutations with family history and ovarian cancer risk.
Frank TS, Manley SA, Olopade OI, Cummings S, Garber JE, Bernhardt B, Antman K, Russo D, Wood ME, Mullineau L, Isaacs C, Peshkin B, Buys S, Venne V, Rowley PT, Loader S, Offit K, Robson M, Hampel H, Brener D, Winer EP, Clark S, Weber B, Strong LC, Thomas A. Sequence analysis of BRCA1 and BRCA2: correlation of mutations with family history and ovarian cancer risk. Journal Of Clinical Oncology 1998, 16: 2417-25. PMID: 9667259, DOI: 10.1200/jco.1998.16.7.2417.Peer-Reviewed Original Research