2019
Community Health Workers Improve Linkage to Hypertension Care in Western Kenya
Vedanthan R, Kamano JH, DeLong AK, Naanyu V, Binanay CA, Bloomfield GS, Chrysanthopoulou SA, Finkelstein EA, Hogan JW, Horowitz CR, Inui TS, Menya D, Orango V, Velazquez EJ, Were MC, Kimaiyo S, Fuster V. Community Health Workers Improve Linkage to Hypertension Care in Western Kenya. Journal Of The American College Of Cardiology 2019, 74: 1897-1906. PMID: 31487546, PMCID: PMC6788970, DOI: 10.1016/j.jacc.2019.08.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntihypertensive AgentsBlood PressureBlood Pressure DeterminationCluster AnalysisCommunicationCommunity Health ServicesCommunity Health WorkersFemaleHealth BehaviorHealth PromotionHealth Services AccessibilityHealth Services ResearchHumansHypertensionKenyaMaleMedication AdherenceMiddle AgedRisk FactorsSmartphoneSystoleTelemedicineConceptsCommunity health workersElevated blood pressureBlood pressureSystolic BPUsual careHealth workersHypertension careCovariate-adjusted mixed effects modelAverage overall followBaseline systolic BPHypertension care programCo-primary outcomesSystolic blood pressureSBP reductionHypertension controlOverall followSBP changeRisk factorsCare programLinkage of individualsCareMixed effects modelsGreater reductionMobile healthMortalityEffects of a Cookstove Intervention on Cardiac Structure, Cardiac Function, and Blood Pressure in Western Kenya
Bloomfield GS, Kirwa K, Agarwal A, Eliot MN, Alenezi F, Carter EJ, Foster MC, Kimaiyo S, Lumsden R, Menya D, Mitter SS, Velazquez EJ, Vedanthan R, Wellenius GA. Effects of a Cookstove Intervention on Cardiac Structure, Cardiac Function, and Blood Pressure in Western Kenya. Journal Of The American Society Of Echocardiography 2019, 32: 427-430. PMID: 30665729, DOI: 10.1016/j.echo.2018.11.013.Peer-Reviewed Original Research
2017
Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya
Temu TM, Lane KA, Shen C, Ng'ang'a L, Akwanalo CO, Chen PS, Emonyi W, Heckbert SR, Koech MM, Manji I, Vatta M, Velazquez EJ, Wessel J, Kimaiyo S, Inui TS, Bloomfield GS. Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya. PLOS ONE 2017, 12: e0185204. PMID: 28934312, PMCID: PMC5608343, DOI: 10.1371/journal.pone.0185204.Peer-Reviewed Original ResearchConceptsValvular AFValvular heart diseaseAtrial fibrillationNVAF patientsAF patientsHeart diseaseNon-valvular atrial fibrillationGlobal cardiovascular disease burdenValvular atrial fibrillationRates of hypertensionCardiovascular disease burdenLong-term outcomesProspective data collectionAnticoagulation therapyClinical characteristicsCohort studyClinical profileHeart failureOverall mortalityClinical featuresComorbid conditionsFatal outcomeMean ageFemale sexDisease burdenHousehold Air Pollution Is Associated with Altered Cardiac Function among Women in Kenya
Agarwal A, Kirwa K, Eliot MN, Alenezi F, Menya D, Mitter SS, Velazquez EJ, Vedanthan R, Wellenius GA, Bloomfield GS. Household Air Pollution Is Associated with Altered Cardiac Function among Women in Kenya. American Journal Of Respiratory And Critical Care Medicine 2017, 197: 958-961. PMID: 28925740, PMCID: PMC6020413, DOI: 10.1164/rccm.201704-0832le.Peer-Reviewed Original ResearchApproaches to Sustainable Capacity Building for Cardiovascular Disease Care in Kenya
Barasa FA, Vedanthan R, Pastakia SD, Crowe SJ, Aruasa W, Sugut WK, White R, Ogola ES, Bloomfield GS, Velazquez EJ. Approaches to Sustainable Capacity Building for Cardiovascular Disease Care in Kenya. Cardiology Clinics 2017, 35: 145-152. PMID: 27886785, DOI: 10.1016/j.ccl.2016.08.014.Peer-Reviewed Original ResearchConceptsCardiovascular disease careHealth care infrastructureDiseases of povertyMiddle-income countriesDisease careCardiovascular diseaseNoncommunicable diseasesTherapeutic strategiesDiagnostic capacityHigh-quality medicationsCare infrastructureEpidemic levelsHealth careDiseasePhysical injuryCareTraffic accidents
2016
Markers of Atherosclerosis, Clinical Characteristics, and Treatment Patterns in Heart Failure A Case-Control Study of Middle-Aged Adult Heart Failure Patients in Rural Kenya
Bloomfield GS, DeLong AK, Akwanalo CO, Hogan JW, Carter EJ, Aswa DF, Binanay C, Koech M, Kimaiyo S, Velazquez EJ. Markers of Atherosclerosis, Clinical Characteristics, and Treatment Patterns in Heart Failure A Case-Control Study of Middle-Aged Adult Heart Failure Patients in Rural Kenya. Global Heart 2016, 11: 97-107. PMID: 27102027, PMCID: PMC4843836, DOI: 10.1016/j.gheart.2015.12.014.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnkle Brachial IndexAtherosclerosisBiomarkersCardiomyopathy, DilatedCase-Control StudiesDyslipidemiasEchocardiographyElectrocardiographyFemaleGuideline AdherenceHeart FailureHumansHypertensionKenyaLogistic ModelsMaleMiddle AgedMyocardial IschemiaOdds RatioPractice Guidelines as TopicRisk FactorsRural PopulationConceptsAnkle-brachial indexAtherosclerotic risk factorsIschemic heart failureHeart failureCase-control studyWall motion abnormalitiesRisk factorsMotion abnormalitiesAdult heart failure patientsHuman immunodeficiency virus (HIV) infectionA Case-Control StudyContribution of atherosclerosisImmunodeficiency virus infectionMarker of atherosclerosisHeart failure patientsMultivariable logistic regressionPhysical examination findingsConfidence intervalsRural KenyaIschemic patternLipid testingClinical characteristicsFailure patientsMost patientsExamination findings
2015
Building Sustainable Capacity for Cardiovascular Care at a Public Hospital in Western Kenya
Binanay CA, Akwanalo CO, Aruasa W, Barasa FA, Corey GR, Crowe S, Esamai F, Einterz R, Foster MC, Gardner A, Kibosia J, Kimaiyo S, Koech M, Korir B, Lawrence JE, Lukas S, Manji I, Maritim P, Ogaro F, Park P, Pastakia SD, Sugut W, Vedanthan R, Yanoh R, Velazquez EJ, Bloomfield GS. Building Sustainable Capacity for Cardiovascular Care at a Public Hospital in Western Kenya. Journal Of The American College Of Cardiology 2015, 66: 2550-2560. PMID: 26653630, PMCID: PMC4680855, DOI: 10.1016/j.jacc.2015.09.086.Peer-Reviewed Original ResearchConceptsMiddle-income countriesPublic referral hospitalCardiovascular disease deathsWorld Health Organization frameworkResource-limited settingsHealth care systemReferral hospitalSubspecialty careDisease deathsCardiovascular healthChronic diseasesCardiovascular diseaseCardiovascular careMedical CenterCardiovascular servicesInfectious diseasesHealth systemCare systemDiseaseHealth partnershipsHospitalStepwise approachCareWestern KenyaAcademic partnershipsGenetic mutations in African patients with atrial fibrillation: Rationale and design of the Study of Genetics of Atrial Fibrillation in an African Population (SIGNAL)
Bloomfield GS, Temu TM, Akwanalo CO, Chen PS, Emonyi W, Heckbert SR, Koech MM, Manji I, Shen C, Vatta M, Velazquez EJ, Wessel J, Kimaiyo S, Inui TS. Genetic mutations in African patients with atrial fibrillation: Rationale and design of the Study of Genetics of Atrial Fibrillation in an African Population (SIGNAL). American Heart Journal 2015, 170: 455-464.e5. PMID: 26385028, PMCID: PMC4575772, DOI: 10.1016/j.ahj.2015.06.008.Peer-Reviewed Original ResearchConceptsValvular atrial fibrillationNonvalvular atrial fibrillationValvular heart diseaseAtrial fibrillationHeart diseaseCurrent tobacco smokingHistory of strokeCase-control studyGroup morbidityGenetic associationTobacco smokingSaharan AfricaMean ageAfrican patientsCardiovascular diseaseClinical phenotypingFibrillationPrimary analysisPatientsControl populationGenetic testingMorbidityDiseaseGenetic mutationsMost participantsImplementation of Management Strategies for Diabetes and Hypertension From Local to Global Health in Cardiovascular Diseases
Bloomfield GS, Wang TY, Boulware LE, Califf RM, Hernandez AF, Velazquez EJ, Peterson ED, Li JS. Implementation of Management Strategies for Diabetes and Hypertension From Local to Global Health in Cardiovascular Diseases. Global Heart 2015, 10: 31-38. PMID: 25754564, PMCID: PMC4754665, DOI: 10.1016/j.gheart.2014.12.010.Peer-Reviewed Original ResearchConceptsCardiovascular diseaseNetwork-based careFuture cardiovascular diseasePopulation risk stratificationUniversity Health CentreSuccessful treatment interventionsChronic conditionsHealth centersTreatment interventionsHypertensionDiabetesImproved healthGlobal healthMajor causal factorDiseaseHealthManagement strategiesCausal factorsPrevalenceCare
2014
Factors Associated With Isolated Right Heart Failure in Women A Pilot Study From Western Kenya
Lagat DK, DeLong AK, Wellenius GA, Carter EJ, Bloomfield GS, Velazquez EJ, Hogan J, Kimaiyo S, Sherman CB. Factors Associated With Isolated Right Heart Failure in Women A Pilot Study From Western Kenya. Global Heart 2014, 9: 249-254. PMID: 25667096, PMCID: PMC4405788, DOI: 10.1016/j.gheart.2014.04.003.Peer-Reviewed Original ResearchConceptsRight heart failureOccupational dust exposureAirflow limitationHeart failureControl subjectsIndoor air pollutionDust exposureIsolated right heart failureHuman immunodeficiency virus (HIV) testingPilot studySmall observational studiesCase-control studyKitchen ventilationSpecific environmental exposuresWestern KenyaSurrogate measureA Pilot StudyAnalysis of subgroupsSmoke exposure timeExpiratory volumeHIV positivityReferral hospitalWalk testOccupational dustThromboembolic diseaseBlood pressure level impacts risk of death among HIV seropositive adults in Kenya: a retrospective analysis of electronic health records
Bloomfield GS, Hogan JW, Keter A, Holland TL, Sang E, Kimaiyo S, Velazquez EJ. Blood pressure level impacts risk of death among HIV seropositive adults in Kenya: a retrospective analysis of electronic health records. BMC Infectious Diseases 2014, 14: 284. PMID: 24886474, PMCID: PMC4046023, DOI: 10.1186/1471-2334-14-284.Peer-Reviewed Original ResearchConceptsSystolic blood pressureLower blood pressureHigher systolic blood pressureCardiovascular risk factorsBlood pressure levelsBlood pressureHigh blood pressureHigher mortality riskMortality rateHazard ratioRisk factorsIncidence rateRetrospective analysisMortality riskLarge HIV treatment programHuman immunodeficiency virus (HIV) infectionNormal systolic blood pressureProportional hazards regression modelsCox proportional hazards modelAdvanced HIV diseaseNon-communicable causeHIV-seropositive individualsHIV-seropositive adultsImmunodeficiency virus infectionHIV treatment programsOptimizing linkage and retention to hypertension care in rural Kenya (LARK hypertension study): study protocol for a randomized controlled trial
Vedanthan R, Kamano JH, Naanyu V, Delong AK, Were MC, Finkelstein EA, Menya D, Akwanalo CO, Bloomfield GS, Binanay CA, Velazquez EJ, Hogan JW, Horowitz CR, Inui TS, Kimaiyo S, Fuster V. Optimizing linkage and retention to hypertension care in rural Kenya (LARK hypertension study): study protocol for a randomized controlled trial. Trials 2014, 15: 143. PMID: 24767476, PMCID: PMC4113229, DOI: 10.1186/1745-6215-15-143.Peer-Reviewed Original ResearchMeSH KeywordsBlack PeopleBlood PressureCell PhoneClinical ProtocolsCommunicationCommunity Health ServicesCommunity Health WorkersCost-Benefit AnalysisHealth BehaviorHealth Care CostsHealth Knowledge, Attitudes, PracticeHumansHypertensionKenyaMotivational InterviewingPatient CompliancePatientsProfessional-Patient RelationsResearch DesignRural Health ServicesTime FactorsTreatment OutcomeConceptsCommunity health workersHypertension careBlood pressureHealth workersHypertensive individualsMethods/designThis studyCo-primary outcome measuresNon-communicable disease managementHypertension care programDisability-adjusted life yearsSystolic blood pressureOne-year changeHealth Belief ModelCost-effectiveness analysisUsual careMiddle-income countriesHypertension managementHypertension treatmentControl rateRisk factorsOutcome measuresDesignThis studyBehavioral communication strategyCare programLife yearsNurse Management of Hypertension in Rural Western Kenya: Implementation Research to Optimize Delivery
Vedanthan R, Kamano JH, Horowitz CR, Ascheim D, Velazquez EJ, Kimaiyo S, Fuster V. Nurse Management of Hypertension in Rural Western Kenya: Implementation Research to Optimize Delivery. Annals Of Global Health 2014, 80: 5-12. PMID: 24751560, PMCID: PMC4036099, DOI: 10.1016/j.aogh.2013.12.002.Peer-Reviewed Original ResearchConceptsRural western KenyaNurse managementBlood pressureNoncommunicable disease managementSystolic blood pressurePrimary outcome measureLong-term treatmentWestern KenyaHypertensive patientsHypertensive individualsMiddle-income countriesHypertension managementHypertension treatmentControl rateRisk factorsHypertensionOutcome measuresOptimize deliveryFull-time equivalentsEffectiveness of strategiesImplementation researchNursesDisease managementFeasibility testingRecord-keeping tool
2011
Hypertension and Obesity as Cardiovascular Risk Factors among HIV Seropositive Patients in Western Kenya
Bloomfield GS, Hogan JW, Keter A, Sang E, Carter EJ, Velazquez EJ, Kimaiyo S. Hypertension and Obesity as Cardiovascular Risk Factors among HIV Seropositive Patients in Western Kenya. PLOS ONE 2011, 6: e22288. PMID: 21779407, PMCID: PMC3136516, DOI: 10.1371/journal.pone.0022288.Peer-Reviewed Original ResearchConceptsPrevalence of hypertensionOverweight/obesityLarge HIV treatment programCardiovascular risk factorsHIV treatment programsLogistic regression analysisRisk factorsSystolic/diastolic blood pressureAssociated cardiovascular risk factorsTreatment programMultiple logistic regression analysisHIV-seropositive individualsHIV-seropositive patientsDiastolic blood pressureOverweight/obesePrevalence of HIVPercent of menAge categoriesOrdinal logistic regression analysisRegression analysisHigher age categoriesElectronic medical recordsWestern KenyaCD4 countSeropositive patients