2018
Clinical and Echocardiographic Predictors of Outcomes in Patients With Pulmonary Hypertension
Siddiqui I, Rajagopal S, Brucker A, Chiswell K, Christopher B, Alenezi F, Mandawat A, Rivera D, Arges K, Tapson V, Kisslo J, Velazquez E, Douglas PS, Samad Z. Clinical and Echocardiographic Predictors of Outcomes in Patients With Pulmonary Hypertension. The American Journal Of Cardiology 2018, 122: 872-878. PMID: 30093068, PMCID: PMC6280670, DOI: 10.1016/j.amjcard.2018.05.019.Peer-Reviewed Original ResearchConceptsPrecapillary pulmonary hypertensionRV global longitudinal strainPulmonary hypertensionEchocardiographic parametersHard outcomesPulmonary arterial hypertension medicationsClass III symptomsREVEAL risk scoreRight heart functionCohort of patientsCumulative incidence rateCurrent clinical guidelinesGlobal longitudinal strainEchocardiographic predictorsHypertension medicationsNT-proBNPTransthoracic echocardiographyWalk distanceUnivariable analysisMean ageClinical guidelinesIncidence rateMultivariable modelSurrogate outcomesRisk score
2017
Improving on the diagnostic characteristics of echocardiography for pulmonary hypertension
Broderick-Forsgren K, Davenport CA, Sivak JA, Hargett CW, Foster MC, Monteagudo A, Armour A, Rajagopal S, Arges K, Velazquez EJ, Samad Z. Improving on the diagnostic characteristics of echocardiography for pulmonary hypertension. The International Journal Of Cardiovascular Imaging 2017, 33: 1341-1349. PMID: 28337558, DOI: 10.1007/s10554-017-1114-2.Peer-Reviewed Original ResearchMeSH KeywordsArea Under CurveCardiac CatheterizationEchocardiographyHumansHypertension, PulmonaryHypertrophy, Right VentricularModels, CardiovascularPredictive Value of TestsPulmonary ArteryReproducibility of ResultsRetrospective StudiesROC CurveVentricular Dysfunction, RightVentricular Function, RightVentricular PressureConceptsValue of echoRight heart catheterizationPulmonary hypertensionComplex congenital heart diseaseRight heart parametersEcho parametersCongenital heart diseaseVentricular assist deviceDiagnostic characteristicsTime of studyLower RVSPPA enlargementRV dysfunctionRV enlargementEchocardiographic parametersHeart catheterizationHeart transplantationAdult patientsProspective cohortMechanical ventilationRetrospective studyHeart diseaseAssist deviceRVSPScreening test
2016
Platypnea-Orthodeoxia Syndrome: To Shunt or Not to Shunt, That is the Question
Klein MR, Kiefer TL, Velazquez EJ. Platypnea-Orthodeoxia Syndrome: To Shunt or Not to Shunt, That is the Question. Texas Heart Institute Journal 2016, 43: 264-6. PMID: 27303248, PMCID: PMC4894711, DOI: 10.14503/thij-15-5280.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiac CatheterizationCardiac Surgical ProceduresDecision MakingDextrocardiaDyspneaFemaleForamen Ovale, PatentHeart Septal Defects, AtrialHumansHypoxiaSyndromeConceptsRight atrial pressurePatent foramenAtrial pressureLow right atrial pressureRight-sided heart catheterizationFirst-line therapyPlatypnea-orthodeoxia syndromePercutaneous patent foramenPulmonary arteriovenous malformationsUpright positionCardiac causesHeart catheterizationTransient hypoxemiaTransthoracic echocardiogramTransthoracic echocardiographyLeft shuntingSyncopal episodesPercutaneous closureTransesophageal echocardiogramEmergency departmentOxygen supplementationIntracardiac shuntingArteriovenous malformationsChest radiographsOxygen saturationImplementing a Continuous Quality Improvement Program in a High-Volume Clinical Echocardiography Laboratory
Samad Z, Minter S, Armour A, Tinnemore A, Sivak JA, Sedberry B, Strub K, Horan SM, Harrison JK, Kisslo J, Douglas PS, Velazquez EJ. Implementing a Continuous Quality Improvement Program in a High-Volume Clinical Echocardiography Laboratory. Circulation Cardiovascular Imaging 2016, 9: e003708. PMID: 26957220, DOI: 10.1161/circimaging.115.003708.Peer-Reviewed Original ResearchMeSH KeywordsAortic ValveAortic Valve StenosisCardiac CatheterizationCritical PathwaysEchocardiography, DopplerFeasibility StudiesHemodynamicsHospitals, High-VolumeHumansObserver VariationPatient Care TeamPractice Patterns, Physicians'Predictive Value of TestsProgram EvaluationProspective StudiesQuality ImprovementQuality Indicators, Health CareReproducibility of ResultsSeverity of Illness IndexWorkflowConceptsAortic stenosisCatheterization dataContinuous quality improvementMean gradientAortic valve mean gradientCQI teamClinical echocardiography laboratoryGreater aortic stenosisProportion of patientsReferral of patientsPrimary outcome measureContinuous quality improvement programQuality Improvement ProgramAortic gradientCardiac catheterizationEchocardiographic diagnosisEchocardiography studyPractice patternsInvasive studiesOutcome measuresEchocardiography laboratoryValve hemodynamicsSecond sonographerCatheterizationCQI program
2015
Outcomes of Anatomical versus Functional Testing for Coronary Artery Disease
Douglas PS, Hoffmann U, Patel MR, Mark DB, Al-Khalidi HR, Cavanaugh B, Cole J, Dolor RJ, Fordyce CB, Huang M, Khan MA, Kosinski AS, Krucoff MW, Malhotra V, Picard MH, Udelson JE, Velazquez EJ, Yow E, Cooper LS, Lee KL. Outcomes of Anatomical versus Functional Testing for Coronary Artery Disease. New England Journal Of Medicine 2015, 372: 1291-1300. PMID: 25773919, PMCID: PMC4473773, DOI: 10.1056/nejmoa1415516.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseCoronary artery diseaseCTA groupSymptomatic patientsArtery diseaseComposite primary end pointPrimary end-point eventEnd pointRadiation exposureInvasive cardiac catheterizationMajor procedural complicationsPrimary end pointSecondary end pointsEnd-point eventsCumulative radiation exposureMedian followChest painUnstable anginaCardiac catheterizationMore patientsProcedural complicationsClinical outcomesRandomized trialsAnatomical testingMean age
2012
Race and gender variation in the QT interval and its association with mortality in patients with coronary artery disease: Results from the Duke Databank for Cardiovascular Disease (DDCD)
Williams ES, Thomas KL, Broderick S, Shaw LK, Velazquez EJ, Al-Khatib SM, Daubert JP. Race and gender variation in the QT interval and its association with mortality in patients with coronary artery disease: Results from the Duke Databank for Cardiovascular Disease (DDCD). American Heart Journal 2012, 164: 434-441. PMID: 22980312, DOI: 10.1016/j.ahj.2012.05.024.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseCause mortalityArtery diseaseProlonged QTcRisk factorsQT intervalMortality riskLow glomerular filtration rateHigher diastolic blood pressureNative coronary artery stenosisCardiac risk factorsLow ejection fractionDiastolic blood pressureGlomerular filtration rateCoronary artery stenosisRisk of deathCardiac catheterizationCardiac eventsDuke DatabankBlood pressureEjection fractionQTc intervalQTc prolongationArtery stenosisBaseline electrocardiogramLong-Term Survival of Patients With Ischemic Cardiomyopathy Treated by Coronary Artery Bypass Grafting Versus Medical Therapy
Velazquez EJ, Williams JB, Yow E, Shaw LK, Lee KL, Phillips HR, O'Connor CM, Smith PK, Jones RH. Long-Term Survival of Patients With Ischemic Cardiomyopathy Treated by Coronary Artery Bypass Grafting Versus Medical Therapy. The Annals Of Thoracic Surgery 2012, 93: 523-530. PMID: 22269720, PMCID: PMC3638256, DOI: 10.1016/j.athoracsur.2011.10.064.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCardiac CatheterizationCardiovascular AgentsComorbidityCoronary Artery BypassDatabases, FactualFemaleFollow-Up StudiesHeart FailureHumansKaplan-Meier EstimateMaleMiddle AgedMitral Valve InsufficiencyModels, CardiovascularMyocardial IschemiaNorth CarolinaRetrospective StudiesRisk FactorsStroke VolumeTreatment OutcomeConceptsVentricular ejection fractionCoronary artery diseaseMedical therapyArtery diseaseEjection fractionCanadian Cardiovascular Society class III anginaLeft ventricular ejection fractionRisk-adjusted mortality ratesClass III anginaLeft main diseaseCoronary artery bypassLeft main stenosisLong-term mortalityIschemic heart diseaseTrial entry criteriaAcute myocardial infarctionMain outcome measuresPropensity score analysisArtery bypassCohort studyMain stenosisObservational cohortSurvival benefitCardiac catheterizationDuke Databank
2006
Predicting significant coronary artery disease in patients with left ventricular dysfunction
Whellan DJ, Tuttle RH, Velazquez EJ, Shaw LK, Jollis JG, Ellis W, O'Connor CM, Califf RM, Borges-Neto S. Predicting significant coronary artery disease in patients with left ventricular dysfunction. American Heart Journal 2006, 152: 340-347. PMID: 16875920, DOI: 10.1016/j.ahj.2005.12.001.Peer-Reviewed Original ResearchConceptsSignificant coronary artery diseaseCoronary artery diseaseSegmental wall motion abnormalitiesLeft ventricular dysfunctionWall motion abnormalitiesEjection functionCardiac catheterizationVentricular dysfunctionArtery diseaseMedian ageMotion abnormalitiesLikelihood of CADAccurate baseline assessmentPatients' median ageMajor epicardial vesselsDiagnostic cardiac catheterizationNumber of patientsUnnecessary invasive proceduresStepwise logistic regressionClinical characteristicsEchocardiographic parametersPrevalent comorbiditiesDuke DatabankHeart failureDiabetes mellitus
2005
Left Ventricular Assessment in Myocardial Infarction: The VALIANT Registry
Hernandez AF, Velazquez EJ, Solomon SD, Kilaru R, Diaz R, O’Connor C, Ertl G, Maggioni AP, Rouleau JL, van Gilst W, Pfeffer MA, Califf RM. Left Ventricular Assessment in Myocardial Infarction: The VALIANT Registry. JAMA Internal Medicine 2005, 165: 2162-2169. PMID: 16217008, DOI: 10.1001/archinte.165.18.2162.Peer-Reviewed Original ResearchConceptsHeart failureMyocardial infarctionLV assessmentCardiac catheterizationVentricular assessmentAcute Myocardial Infarction RegistryAngiotensin-converting enzyme inhibitorClinical heart failureMyocardial Infarction RegistryLeft ventricular functionAcute myocardial infarctionQuality of careHospital mortalityHospital outcomesHospital stayBaseline characteristicsDischarge medicationsVentricular functionMultivariable modelPatientsPropensity analysisEnzyme inhibitorsLower mortalityCatheterizationEchocardiography
2004
Clinical characteristics and referral pattern of patients with left ventricular dysfunction and significant coronary artery disease undergoing radionuclide imaging
Bourque JM, Velazquez EJ, Borges-Neto S, Shaw LK, Whellan DJ, O'Connor C. Clinical characteristics and referral pattern of patients with left ventricular dysfunction and significant coronary artery disease undergoing radionuclide imaging. Journal Of Nuclear Cardiology 2004, 11: 118-125. PMID: 15052242, DOI: 10.1016/j.nuclcard.2003.09.005.Peer-Reviewed Original ResearchConceptsSignificant coronary artery diseaseCoronary artery diseaseLeft ventricular dysfunctionReferral patternsLV dysfunctionVentricular dysfunctionArtery diseaseMyocardial infarctionObservational studyMyocardial perfusion imaging resultsCharlson Comorbidity IndexHeart failure symptomsCongestive heart failureLogistic regression modelingNuclear perfusionCohort patientsComorbidity indexPrior revascularizationBaseline characteristicsCatheterization resultsClinical characteristicsCardiac revascularizationEjection fractionHeart failurePerfusion testing
2002
Comparison of coronary artery bypass grafting versus medical therapy on long-term outcome in patients with ischemic cardiomyopathy (a 25-year experience from the Duke Cardiovascular Disease Databank)
O’Connor C, Velazquez EJ, Gardner LH, Smith PK, Newman MF, Landolfo KP, Lee KL, Califf RM, Jones RH. Comparison of coronary artery bypass grafting versus medical therapy on long-term outcome in patients with ischemic cardiomyopathy (a 25-year experience from the Duke Cardiovascular Disease Databank). The American Journal Of Cardiology 2002, 90: 101-107. PMID: 12106836, DOI: 10.1016/s0002-9149(02)02429-3.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiac CatheterizationComorbidityCoronary AngiographyCoronary Artery BypassCoronary Artery DiseaseDisease-Free SurvivalFemaleFollow-Up StudiesHeart FailureHumansMaleMiddle AgedOutcome and Process Assessment, Health CareSurvival AnalysisTimeTreatment OutcomeVentricular Dysfunction, LeftConceptsCoronary artery bypass surgeryLong-term outcomesMedical therapyCoronary diseaseIschemic cardiomyopathyNew York Heart Association class IILeft ventricular ejection fractionCox proportional hazards modelDuke University Medical CenterDays of catheterizationInitial cardiac catheterizationMedical therapy armObservational treatment comparisonsCoronary artery bypassHeart failure symptomsMedical therapy groupVentricular systolic dysfunctionArtery bypass surgeryVentricular ejection fractionCoronary artery diseaseEpicardial coronary vesselsProportional hazards modelUniversity Medical CenterCABG groupTherapy arm