2019
Association between systolic ejection time and outcomes in heart failure by ejection fraction
Patel PA, Ambrosy AP, Phelan M, Alenezi F, Chiswell K, Van Dyke MK, Tomfohr J, Honarpour N, Velazquez EJ. Association between systolic ejection time and outcomes in heart failure by ejection fraction. European Journal Of Heart Failure 2019, 22: 1174-1182. PMID: 31863532, PMCID: PMC7493053, DOI: 10.1002/ejhf.1659.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsDiabetes Mellitus, Type 2FemaleHeart FailureHumansMaleMiddle AgedPercutaneous Coronary InterventionPrognosisStroke VolumeConceptsSystolic ejection timeEjection fractionHeart failureClinical outcomesVentricular systolic ejection timeOutpatient transthoracic echocardiogramReduced ejection fractionTertiary referral centerMultivariable logistic regressionHFrEF patientsHF patientsReferral centerTransthoracic echocardiogramAmbulatory patientsHF populationEjection timeEligibility criteriaLogistic regressionPatientsOutcomesAssociationHFpEFEchocardiogramPercutaneous coronary intervention outcomes in patients with stable coronary disease and left ventricular systolic dysfunction
DeVore AD, Yow E, Krucoff MW, Sherwood MW, Shaw LK, Chiswell K, O'Connor CM, Ohman EM, Velazquez EJ. Percutaneous coronary intervention outcomes in patients with stable coronary disease and left ventricular systolic dysfunction. ESC Heart Failure 2019, 6: 1233-1242. PMID: 31560171, PMCID: PMC6989282, DOI: 10.1002/ehf2.12510.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary AngiographyCoronary Artery DiseaseFemaleHeart FailureHumansMaleMiddle AgedPercutaneous Coronary InterventionPropensity ScoreRetrospective StudiesTreatment OutcomeVentricular Dysfunction, LeftConceptsStable coronary artery diseasePercutaneous coronary interventionCoronary artery diseaseVentricular systolic dysfunctionSevere left ventricular systolic dysfunctionLeft ventricular systolic dysfunctionSystolic dysfunctionMedical therapyCardiovascular hospitalizationAddition of PCICanadian Cardiovascular Society class IIIImpact of PCIPercutaneous coronary intervention outcomesDuke University Medical CenterComposite of mortalityPropensity-matched cohortStable coronary diseaseAcute coronary syndromeHigh-risk patientsLong-term mortalityVentricular ejection fractionCox proportional hazardsUniversity Medical CenterCause mortalityCoronary syndromeDoes prior coronary angioplasty affect outcomes of surgical coronary revascularization? Insights from the STICH trial
Nicolau JC, Stevens SR, Al-Khalidi HR, Jatene FB, Furtado RHM, Dallan LAO, Lisboa LAF, Desvigne-Nickens P, Haddad H, Jolicoeur EM, Petrie MC, Doenst T, Michler RE, Ohman EM, Maddury J, Ali I, Deja MA, Rouleau JL, Velazquez EJ, Hill JA. Does prior coronary angioplasty affect outcomes of surgical coronary revascularization? Insights from the STICH trial. International Journal Of Cardiology 2019, 291: 36-41. PMID: 30929973, PMCID: PMC6579621, DOI: 10.1016/j.ijcard.2019.03.029.Peer-Reviewed Original ResearchConceptsPrior percutaneous coronary interventionPercutaneous coronary interventionLeft ventricular ejection fractionSTICH trialCV hospitalizationCV mortalityCause mortalityMedical treatmentSuperiority of CABGOutcomes of patientsSurgical coronary revascularizationCoronary artery bypassVentricular ejection fractionArtery bypassCoronary revascularizationCoronary interventionCoronary angioplastyEjection fractionMedian timeWorse prognosisRandomized treatmentCABGHospitalizationMortalityPatientsPCI and CABG for Treating Stable Coronary Artery Disease JACC Review Topic of the Week
Doenst T, Haverich A, Serruys P, Bonow RO, Kappetein P, Falk V, Velazquez E, Diegeler A, Sigusch H. PCI and CABG for Treating Stable Coronary Artery Disease JACC Review Topic of the Week. Journal Of The American College Of Cardiology 2019, 73: 964-976. PMID: 30819365, DOI: 10.1016/j.jacc.2018.11.053.Peer-Reviewed Original ResearchMeSH KeywordsCoronary AngiographyCoronary Artery BypassCoronary Artery DiseaseHumansPercutaneous Coronary InterventionTreatment OutcomeConceptsPercutaneous coronary interventionMyocardial infarctionStable coronary artery diseaseMajority of infarctsCoronary artery bypassCoronary artery diseaseFlow-limiting lesionsNew infarctsArtery bypassCoronary interventionInfarct reductionArtery diseaseMedical therapyRevascularization proceduresVessel occlusionCABGSurvival effectReview TopicTreatment effectsInfarctionInfarctsIschemia detectionRevascularizationStenosisBypass
2018
Revascularization for Heart Failure Can We Do Better? ∗
Ohman EM, Velazquez EJ. Revascularization for Heart Failure Can We Do Better? ∗. JACC Heart Failure 2018, 6: 527-529. PMID: 29852934, DOI: 10.1016/j.jchf.2018.05.002.Peer-Reviewed Original ResearchCardiomyopathiesHeart FailureHumansMyocardial IschemiaPercutaneous Coronary InterventionVentricular DysfunctionCABG or PCI for Diabetic Patients With Left Ventricular Dysfunction Closing in on the Truth? ∗
Velazquez EJ, Petrie MC. CABG or PCI for Diabetic Patients With Left Ventricular Dysfunction Closing in on the Truth? ∗. Journal Of The American College Of Cardiology 2018, 71: 828-831. PMID: 29471932, DOI: 10.1016/j.jacc.2018.01.014.Peer-Reviewed Original ResearchCoronary Artery BypassDiabetes MellitusHumansPercutaneous Coronary InterventionVentricular Dysfunction, Left
2016
Functional Mitral Regurgitation: Appraising the Evidence Behind Recommended Treatment Strategies
Samad Z, Velazquez EJ. Functional Mitral Regurgitation: Appraising the Evidence Behind Recommended Treatment Strategies. Current Cardiology Reports 2016, 18: 128. PMID: 27796864, DOI: 10.1007/s11886-016-0808-8.Peer-Reviewed Original ResearchMeSH KeywordsDisease ProgressionEchocardiographyEvidence-Based MedicineHeart Valve Prosthesis ImplantationHumansMitral Valve InsufficiencyPercutaneous Coronary InterventionRandomized Controlled Trials as TopicTreatment Outcome
2015
Management and outcomes in patients with moderate or severe functional mitral regurgitation and severe left ventricular dysfunction
Samad Z, Shaw LK, Phelan M, Ersboll M, Risum N, Al-Khalidi HR, Glower DD, Milano CA, Alexander JH, O'Connor CM, Wang A, Velazquez EJ. Management and outcomes in patients with moderate or severe functional mitral regurgitation and severe left ventricular dysfunction. European Heart Journal 2015, 36: 2733-2741. PMID: 26233850, DOI: 10.1093/eurheartj/ehv343.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseSevere mitral regurgitationEvent-free survival benefitHigher event-free survivalSevere functional mitral regurgitationMV surgerySevere LV dysfunctionEvent-free survivalOutcomes of patientsMitral regurgitationFunctional mitral regurgitationIPW adjustmentSystolic dysfunctionLV dysfunctionSurvival benefitEntire cohortTreatment strategiesSevere left ventricular systolic dysfunctionCoronary artery bypass graft surgeryMultivariable Cox proportional hazards modelsSevere left ventricular dysfunctionArtery bypass graft surgeryLeft ventricular systolic dysfunctionCox proportional hazards modelIsolated MV surgery
2014
Surgical Revascularization Is Associated With Maximal Survival in Patients With Ischemic Mitral Regurgitation
Castleberry AW, Williams JB, Daneshmand MA, Honeycutt E, Shaw LK, Samad Z, Lopes RD, Alexander JH, Mathew JP, Velazquez EJ, Milano CA, Smith PK. Surgical Revascularization Is Associated With Maximal Survival in Patients With Ischemic Mitral Regurgitation. Circulation 2014, 129: 2547-2556. PMID: 24744275, PMCID: PMC4142433, DOI: 10.1161/circulationaha.113.005223.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery BypassDatabases, BibliographicFemaleFollow-Up StudiesHeart Valve Prosthesis ImplantationHumansKaplan-Meier EstimateMaleMiddle AgedMitral ValveMitral Valve InsufficiencyMyocardial IschemiaMyocardial RevascularizationPercutaneous Coronary InterventionProportional Hazards ModelsRetrospective StudiesRisk FactorsSeverity of Illness IndexStentsConceptsIschemic mitral regurgitationPercutaneous coronary interventionMitral valve repairSignificant coronary artery diseaseSevere ischemic mitral regurgitationCoronary artery diseaseMitral regurgitationCoronary interventionValve repairMedical treatmentArtery diseaseTreatment strategiesLower mortalityMultivariable Cox proportional hazards analysisCox proportional hazards analysisCoronary artery bypassMitral valve surgeryKaplan-Meier methodProportional hazards analysisMitral regurgitation severitySurgical revascularizationArtery bypassValve surgeryOptimal treatmentCABG