2017
Mental stress-induced left ventricular dysfunction and adverse outcome in ischemic heart disease patients
Sun JL, Boyle SH, Samad Z, Babyak MA, Wilson JL, Kuhn C, Becker RC, Ortel TL, Williams RB, Rogers JG, O’Connor C, Velazquez EJ, Jiang W. Mental stress-induced left ventricular dysfunction and adverse outcome in ischemic heart disease patients. European Journal Of Preventive Cardiology 2017, 24: 591-599. PMID: 28067532, PMCID: PMC6093615, DOI: 10.1177/2047487316686435.Peer-Reviewed Original ResearchMeSH KeywordsAgedCitalopramDisease-Free SurvivalFemaleHumansMaleMental HealthMiddle AgedMultivariate AnalysisMyocardial IschemiaProportional Hazards ModelsRisk AssessmentRisk FactorsSelective Serotonin Reuptake InhibitorsStress, PsychologicalStroke VolumeTime FactorsTreatment OutcomeVentricular Dysfunction, LeftVentricular Function, LeftConceptsMental stress-induced myocardial ischemiaMajor adverse cardiovascular eventsAdverse cardiovascular eventsLeft ventricular ejection fraction changeVentricular ejection fraction changeStable ischemic heart diseaseIschemic heart disease patientsLeft ventricular ejection fractionStress-induced myocardial ischemiaEjection fraction changesVentricular ejection fractionIschemic heart diseaseCardiovascular eventsHeart disease patientsMyocardial ischemiaEjection fractionStudy endpointDisease patientsHeart diseaseMental Stress–Induced Myocardial IschemiaStress-induced left ventricular dysfunctionFuture adverse cardiovascular eventsLeft ventricular dysfunctionHeart failure statusAssociation of indices
2014
Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study
Jiang W, Boyle SH, Ortel TL, Samad Z, Velazquez EJ, Harrison RW, Wilson J, Kuhn C, Williams RB, O’Connor C, Becker RC. Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study. American Heart Journal 2014, 169: 496-507.e1. PMID: 25819856, PMCID: PMC4382806, DOI: 10.1016/j.ahj.2014.12.002.Peer-Reviewed Original ResearchMeSH KeywordsCitalopramElectrocardiographyFemaleHumansMaleMiddle AgedMyocardial IschemiaPlatelet AggregationROC CurveSelective Serotonin Reuptake InhibitorsStress, PsychologicalTreatment OutcomeConceptsMental stress-induced myocardial ischemiaIschemic heart diseaseSerotonin transporter expressionMyocardial ischemiaPlatelet aggregationPlatelet hyperactivityNormal left ventricular responseStable ischemic heart diseaseStress-induced myocardial ischemiaMental stressTransporter expressionAcute coronary syndromeLeft ventricular responseMental stress testMental stress testingCombination of serotoninEligible patientsCardiovascular eventsCardiovascular prognosisCoronary syndromeVentricular responsePlatelet activityHeart diseaseTreatment studiesIschemia
2013
Therapy for Mental Stress–Induced Myocardial Ischemia—Reply
Jiang W, O’Connor C, Velazquez EJ. Therapy for Mental Stress–Induced Myocardial Ischemia—Reply. JAMA 2013, 310: 1401-1402. PMID: 24084928, DOI: 10.1001/jama.2013.277975.Peer-Reviewed Original ResearchCitalopramCoronary DiseaseFemaleHumansMaleMyocardial IschemiaSelective Serotonin Reuptake InhibitorsStress, PsychologicalEffect of Escitalopram on Mental Stress–Induced Myocardial Ischemia: Results of the REMIT Trial
Jiang W, Velazquez EJ, Kuchibhatla M, Samad Z, Boyle SH, Kuhn C, Becker RC, Ortel TL, Williams RB, Rogers JG, O’Connor C. Effect of Escitalopram on Mental Stress–Induced Myocardial Ischemia: Results of the REMIT Trial. JAMA 2013, 309: 2139-2149. PMID: 23695483, PMCID: PMC4378823, DOI: 10.1001/jama.2013.5566.Peer-Reviewed Original ResearchMeSH KeywordsAgedCitalopramCoronary DiseaseDisease ProgressionDouble-Blind MethodElectrocardiographyEmotionsExerciseFemaleHumansMaleMiddle AgedMyocardial IschemiaSelective Serotonin Reuptake InhibitorsStress, PsychologicalVentricular Function, LeftConceptsMental stress-induced myocardial ischemiaStable coronary heart diseaseExercise-induced ischemiaCoronary heart diseaseMyocardial ischemiaHeart diseaseVentricular ejection fraction reductionStress-induced myocardial ischemiaMental stressRegional wall motion abnormalitiesEjection fraction reductionPlacebo-controlled trialST-segment depressionEffect of escitalopramTertiary medical centerWall motion abnormalitiesWeeks of escitalopramSignificant differencesEnd-point assessmentStressor taskEscitalopram groupCardiac eventsEscitalopram treatmentMore patientsTreat analysis
2011
Responses of mental stress–induced myocardial ischemia to escitalopram treatment: Background, design, and method for the Responses of Mental Stress Induced Myocardial Ischemia to Escitalopram Treatment trial
Jiang W, Velazquez EJ, Samad Z, Kuchibhatla M, Martsberger C, Rogers J, Williams R, Kuhn C, Ortel TL, Becker RC, Pristera N, Krishnan R, O'Connor CM. Responses of mental stress–induced myocardial ischemia to escitalopram treatment: Background, design, and method for the Responses of Mental Stress Induced Myocardial Ischemia to Escitalopram Treatment trial. American Heart Journal 2011, 163: 20-26. PMID: 22172432, PMCID: PMC3254211, DOI: 10.1016/j.ahj.2011.09.018.Peer-Reviewed Original ResearchMeSH KeywordsAdultCardiovascular DiseasesCitalopramDepressive DisorderExercise TestHumansMyocardial InfarctionPsychometricsResearch DesignSelective Serotonin Reuptake InhibitorsStress, PsychologicalTreatment OutcomeConceptsMental stress-induced myocardial ischemiaCoronary heart diseaseStable coronary heart diseaseStress-induced myocardial ischemiaMyocardial ischemiaMental Stress–Induced Myocardial IschemiaSelective serotonin reuptake inhibitor (SSRI) treatmentStress testingSerotonin reuptake inhibitor treatmentEjection fraction reductionReuptake inhibitor treatmentMental stress testingPsychometric questionnairesEffects of SSRIsIschemic ST changesInduced Myocardial IschemiaAbnormal wall motionAdult patientsEscitalopram treatmentSSRI treatmentPoor outcomeTreatment trialsPlatelet activityHeart diseaseRisk factors