2019
Durability and Efficacy of Tricuspid Valve Repair in Patients Undergoing Left Ventricular Assist Device Implantation
Barac YD, Nicoara A, Bishawi M, Schroder JN, Daneshmand MA, Hashmi NK, Velazquez E, Rogers JG, Patel CB, Milano CA. Durability and Efficacy of Tricuspid Valve Repair in Patients Undergoing Left Ventricular Assist Device Implantation. JACC Heart Failure 2019, 8: 141-150. PMID: 31838034, PMCID: PMC6995411, DOI: 10.1016/j.jchf.2019.08.016.Peer-Reviewed Original ResearchConceptsLate right heart failureRight heart failureTricuspid valve repairVentricular assist device implantationAssist device implantationTricuspid regurgitationLVAD implantationValve repairDevice implantationMultivariate Cox proportional hazards analysisPostoperative right heart failureCox proportional hazards analysisDurable LVAD implantationSignificant tricuspid regurgitationConsecutive adult patientsIndependent risk factorSevere tricuspid regurgitationProportional hazards analysisDiuretic therapyIndex hospitalizationAdult patientsHeart failureIndependent predictorsEchocardiographic examinationRetrospective review
2018
A meta‐analysis of MitraClip combined with medical therapy vs. medical therapy alone for treatment of mitral regurgitation in heart failure patients
Giannini C, D'ascenzo F, Fiorelli F, Spontoni P, Swaans MJ, Velazquez EJ, Armeni P, Adamo M, De Carlo M, Petronio AS. A meta‐analysis of MitraClip combined with medical therapy vs. medical therapy alone for treatment of mitral regurgitation in heart failure patients. ESC Heart Failure 2018, 5: 1150-1158. PMID: 30191666, PMCID: PMC6300824, DOI: 10.1002/ehf2.12339.Peer-Reviewed Original ResearchMeSH KeywordsConservative TreatmentHeart FailureHeart Valve Prosthesis ImplantationHumansMitral Valve InsufficiencyProsthesis DesignTreatment OutcomeConceptsFunctional mitral regurgitationMedical therapyMitral regurgitationSurvival benefitConservative treatmentPercutaneous mitral valve repairEffect of MitraClipRobust survival benefitSignificant survival benefitCardiac resynchronization therapyEligible observational studiesHeart failure patientsVentricular ejection fractionMitral valve repairPatient-level analysisComprehensive literature searchStudy-level analysisConservative therapyIschemic etiologyPrimary endpointFailure patientsMultivariate adjustmentEjection fractionResynchronization therapySurvival outcomes
2015
The MitraClip and survival in patients with mitral regurgitation at high risk for surgery: A propensity-matched comparison
Velazquez EJ, Samad Z, Al-Khalidi HR, Sangli C, Grayburn PA, Massaro JM, Stevens SR, Feldman TE, Krucoff MW. The MitraClip and survival in patients with mitral regurgitation at high risk for surgery: A propensity-matched comparison. American Heart Journal 2015, 170: 1050-1059.e3. PMID: 26542516, DOI: 10.1016/j.ahj.2015.08.004.Peer-Reviewed Original ResearchConceptsMitraClip patientsCox proportional hazards modelPropensity-matched comparisonSevere MR patientsHigh surgical riskHigh-risk patientsNon-surgical treatmentKaplan-Meier estimatesMitral regurgitation patientsProportional hazards modelSurvival benefitMedical therapySurgical riskMitral regurgitationRelative riskBaseline differencesHigh riskMR patientsHazards modelMitraClipPatientsFurther adjustmentLaboratory databasePropensity scorePatient matching