2017
Sudden cardiac death after acute heart failure hospital admission: insights from ASCEND‐HF
Pokorney SD, Al‐Khatib S, Sun J, Schulte P, O'Connor CM, Teerlink JR, Armstrong PW, Ezekowitz JA, Starling RC, Voors AA, Velazquez EJ, Hernandez AF, Mentz RJ. Sudden cardiac death after acute heart failure hospital admission: insights from ASCEND‐HF. European Journal Of Heart Failure 2017, 20: 525-532. PMID: 29266564, DOI: 10.1002/ejhf.1078.Peer-Reviewed Original ResearchConceptsSudden cardiac deathVT/VFHeart failure hospital admissionsAcute HFCardiac deathHospital admissionVentricular tachycardia/ventricular fibrillationDecompensated Heart Failure (ASCEND-HF) trialChronic obstructive pulmonary diseaseVT/VF eventsEvent ratesComposite event rateMeier event ratesHeart Failure TrialCause mortality ratesDay of admissionObstructive pulmonary diseaseLonger QRS durationCause mortalityBaseline characteristicsComposite endpointEjection fractionPulmonary diseaseASCEND-HFFailure TrialSudden Cardiac Death in Patients With Ischemic Heart Failure Undergoing Coronary Artery Bypass Grafting
Rao MP, Al-Khatib SM, Pokorney SD, She L, Romanov A, Nicolau JC, Lee KL, Carson P, Selzman CH, Stepinska J, Cleland JG, Tungsubutra W, Desvigne-Nickens PM, Sueta CA, Siepe M, Lang I, Feldman AM, Yii M, Rouleau JL, Velazquez EJ. Sudden Cardiac Death in Patients With Ischemic Heart Failure Undergoing Coronary Artery Bypass Grafting. Circulation 2017, 135: 1136-1144. PMID: 28154006, PMCID: PMC5516272, DOI: 10.1161/circulationaha.116.026075.Peer-Reviewed Original ResearchMeSH KeywordsAgedAtrial FibrillationCoronary Artery BypassDeath, Sudden, CardiacFemaleFollow-Up StudiesHeart FailureHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncidenceMaleMiddle AgedMultivariate AnalysisNatriuretic Peptide, BrainPostoperative PeriodProportional Hazards ModelsReceptors, Tumor Necrosis FactorRisk FactorsStroke VolumeVentricular Function, LeftConceptsCoronary artery bypass graft surgerySudden cardiac deathEnd-systolic volume indexB-type natriuretic peptideVentricular ejection fractionSurgical ventricular reconstructionCardiac deathEjection fractionHeart failureNatriuretic peptideVentricular reconstructionPreoperative end-systolic volume indexLow left ventricular ejection fractionIncidence of SCDPredictors of SCDArtery bypass graft surgeryCoronary Artery Bypass GraftingLeft ventricular ejection fractionVolume indexArtery Bypass GraftingBypass graft surgeryIschemic heart failureContemporary clinical trialsBlinded committeeSTICH trial
2013
Early Echocardiographic Deformation Analysis for the Prediction of Sudden Cardiac Death and Life-Threatening Arrhythmias After Myocardial Infarction
Ersbøll M, Valeur N, Andersen MJ, Mogensen UM, Vinther M, Svendsen JH, Møller JE, Kisslo J, Velazquez EJ, Hassager C, Søgaard P, Køber L. Early Echocardiographic Deformation Analysis for the Prediction of Sudden Cardiac Death and Life-Threatening Arrhythmias After Myocardial Infarction. JACC Cardiovascular Imaging 2013, 6: 851-860. PMID: 23850252, DOI: 10.1016/j.jcmg.2013.05.009.Peer-Reviewed Original ResearchMeSH KeywordsAgedArrhythmias, CardiacDeath, Sudden, CardiacDefibrillators, ImplantableDenmarkEchocardiographyElectric CountershockFemaleHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPredictive Value of TestsPrimary PreventionProportional Hazards ModelsProspective StudiesRisk FactorsStroke VolumeTreatment OutcomeVentricular Function, LeftConceptsGlobal longitudinal strainAcute myocardial infarctionSudden cardiac deathMalignant ventricular arrhythmiasMyocardial infarctionNet reclassification indexVentricular arrhythmiasCardiac deathAddition of GLSMeasurement of GLSSCD/VAsChronic ischemic heart failureNovel echocardiographic parametersPrimary composite endpointPrimary composite outcomeIschemic heart failureEchocardiographic parametersPrimary endpointComposite outcomeHospital dischargeLate complicationsMultivariate adjustmentComposite endpointHeart failureRisk stratification
2010
Does Myocardial Perfusion Imaging Provide Incremental Prognostic Information to Left Ventricular Ejection Fraction?
Mudrick DW, Velazquez E, Borges-Neto S. Does Myocardial Perfusion Imaging Provide Incremental Prognostic Information to Left Ventricular Ejection Fraction? Current Cardiology Reports 2010, 12: 155-161. PMID: 20425171, DOI: 10.1007/s11886-010-0093-x.Peer-Reviewed Original ResearchMeSH KeywordsCardiac-Gated Single-Photon Emission Computer-Assisted TomographyCoronary Artery DiseaseDeath, Sudden, CardiacHumansMass ScreeningMyocardial Perfusion ImagingPositron-Emission TomographyPredictive Value of TestsPrognosisRisk AssessmentSensitivity and SpecificityStroke VolumeVentricular Function, LeftConceptsEjection fractionVentricular functionNonfatal cardiac eventsGated single-photon emissionIncremental prognostic informationSignificant coronary diseaseVentricular ejection fractionCoronary artery diseaseOptimal treatment strategySudden cardiac deathNuclear imaging studiesImportant clinical implicationsMyocardial perfusion imagingPositron emission tomographySingle photon emissionIschemic burdenCardiac eventsArtery diseaseCardiac deathCoronary diseasePrognostic informationTreatment strategiesMyocardial perfusionPerfusion imagingBest predictor
2009
Usefulness of the Duke Sudden Cardiac Death Risk Score for Predicting Sudden Cardiac Death in Patients With Angiographic (>75% Narrowing) Coronary Artery Disease
Atwater BD, Thompson VP, Vest RN, Shaw LK, Mazzei WR, Al-Khatib SM, Hranitzky PM, Bahnson TD, Velazquez EJ, Califf RM, Lee KL, Roe MT. Usefulness of the Duke Sudden Cardiac Death Risk Score for Predicting Sudden Cardiac Death in Patients With Angiographic (>75% Narrowing) Coronary Artery Disease. The American Journal Of Cardiology 2009, 104: 1624-1630. PMID: 19962465, DOI: 10.1016/j.amjcard.2009.07.042.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseSCD risk scoreRisk of SCDArtery diseaseRisk scoreSCD riskDepressed left ventricular ejection fractionAngiographic coronary artery diseasePredicting Sudden Cardiac DeathLeft ventricular ejection fractionNative coronary artery stenosisCox proportional hazards modelVentricular ejection fractionSudden cardiac deathCoronary artery stenosisDeath risk scorePatient characteristic variablesRisk prediction toolsDiseased coronary arteriesProportional hazards modelAngiographic characteristicsRisk patientsCardiac deathCoronary angiographyDiabetes mellitusPredictors of sudden cardiac death change with time after myocardial infarction: results from the VALIANT trial
Piccini JP, Zhang M, Pieper K, Solomon SD, Al-Khatib SM, Van de Werf F, Pfeffer MA, McMurray JJ, Califf RM, Velazquez EJ. Predictors of sudden cardiac death change with time after myocardial infarction: results from the VALIANT trial. European Heart Journal 2009, 31: 211-221. PMID: 19854729, DOI: 10.1093/eurheartj/ehp425.Peer-Reviewed Original ResearchConceptsSudden cardiac deathMyocardial infarctionInitial left ventricular ejection fractionRisk of SCDLeft ventricular ejection fractionHigher baseline heart rateBaseline creatinine clearanceBaseline clinical characteristicsRecurrent cardiovascular eventsPrior myocardial infarctionVentricular ejection fractionBaseline heart rateCox proportional hazardsCardiovascular eventsClinical characteristicsCreatinine clearanceCumulative incidenceCardiac deathEjection fractionEntire followRisk stratificationVALIANT trialPost-MIRisk stratifierLandmark analysis
2007
Racial Disparity in the Utilization of Implantable-Cardioverter Defibrillators Among Patients With Prior Myocardial Infarction and an Ejection Fraction of ≤35%
Thomas KL, Al-Khatib SM, Kelsey RC, Bush H, Brosius L, Velazquez EJ, Peterson ED, Gilliam FR. Racial Disparity in the Utilization of Implantable-Cardioverter Defibrillators Among Patients With Prior Myocardial Infarction and an Ejection Fraction of ≤35%. The American Journal Of Cardiology 2007, 100: 924-929. PMID: 17826371, DOI: 10.1016/j.amjcard.2007.04.024.Peer-Reviewed Original ResearchConceptsSudden cardiac deathLeft ventricular systolic dysfunctionVentricular systolic dysfunctionCardiac deathEjection fractionBlack patientsMyocardial infarctionSystolic dysfunctionWhite patientsPrimary preventionSignificant left ventricular systolic dysfunctionLower mean ejection fractionSudden cardiac death rateCardiac death rateMean ejection fractionPrior myocardial infarctionMultivariate logistic regressionImplantable cardioverter defibrillatorClinical characteristicsICD implantationICD useOverall mortalityProphylactic implantationPatient raceNational registry