Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study
Jiang W, Boyle SH, Ortel TL, Samad Z, Velazquez EJ, Harrison RW, Wilson J, Kuhn C, Williams RB, O’Connor C, Becker RC. Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study. American Heart Journal 2014, 169: 496-507.e1. PMID: 25819856, PMCID: PMC4382806, DOI: 10.1016/j.ahj.2014.12.002.Peer-Reviewed Original ResearchConceptsMental stress-induced myocardial ischemiaIschemic heart diseaseSerotonin transporter expressionMyocardial ischemiaPlatelet aggregationPlatelet hyperactivityNormal left ventricular responseStable ischemic heart diseaseStress-induced myocardial ischemiaMental stressTransporter expressionAcute coronary syndromeLeft ventricular responseMental stress testMental stress testingCombination of serotoninEligible patientsCardiovascular eventsCardiovascular prognosisCoronary syndromeVentricular responsePlatelet activityHeart diseaseTreatment studiesIschemiaMetabolomics analysis reveals insights into biochemical mechanisms of mental stress-induced left ventricular dysfunction
Boyle SH, Matson WR, Velazquez EJ, Samad Z, Williams RB, Sharma S, Thomas B, Wilson JL, O’Connor C, Jiang W. Metabolomics analysis reveals insights into biochemical mechanisms of mental stress-induced left ventricular dysfunction. Metabolomics 2014, 11: 571-582. PMID: 25983674, PMCID: PMC4431771, DOI: 10.1007/s11306-014-0718-y.Peer-Reviewed Original ResearchLeft ventricular dysfunctionLeft ventricular ejection fractionMental stress-induced myocardial ischemiaStress-induced left ventricular dysfunctionNormal left ventricular responseStress-induced myocardial ischemiaCoronary heart disease patientsLeft ventricular responseVentricular ejection fractionAdult CHD patientsHeart disease patientsConventional risk indicatorsVentricular dysfunctionAdverse eventsEjection fractionStable CHDVentricular responseCHD patientsDisease patientsMyocardial ischemiaLVD groupCardiovascular conditionsMental stressorsPatientsGreater risk