2023
Cardiology Encounters for Underrepresented Racial and Ethnic Groups with Human Immunodeficiency Virus and Borderline Cardiovascular Disease Risk
Bloomfield G, Hill C, Chiswell K, Cooper L, Gray S, Longenecker C, Louzao D, Marsolo K, Meissner E, Morse C, Muiruri C, Thomas K, Velazquez E, Vicini J, Pettit A, Sanders G, Okeke N. Cardiology Encounters for Underrepresented Racial and Ethnic Groups with Human Immunodeficiency Virus and Borderline Cardiovascular Disease Risk. Journal Of Racial And Ethnic Health Disparities 2023, 11: 1509-1519. PMID: 37160576, PMCID: PMC10632543, DOI: 10.1007/s40615-023-01627-0.Peer-Reviewed Original ResearchBody mass indexCVD riskCardiovascular diseaseCVD risk factor managementCox proportional hazards regressionHigher body mass indexUrban residenceRisk factor managementCardiovascular disease riskHuman immunodeficiency virusProportional hazards regressionAssociation of patientHigh-risk individualsAcademic medical centerAmbulatory visitsMedian ageMass indexProvider factorsAtrial fibrillationHazards regressionImmunodeficiency virusResultsA totalFactor managementInsurance typeMedical Center
2020
Prevention of cardiovascular disease for historically marginalized racial and ethnic groups living with HIV: A narrative review of the literature
Muiruri C, Longenecker CT, Meissner EG, Okeke NL, Pettit AC, Thomas K, Velazquez E, Bloomfield GS. Prevention of cardiovascular disease for historically marginalized racial and ethnic groups living with HIV: A narrative review of the literature. Progress In Cardiovascular Diseases 2020, 63: 142-148. PMID: 32057785, PMCID: PMC7237291, DOI: 10.1016/j.pcad.2020.02.006.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsCardiovascular DiseasesComorbidityHealth Status DisparitiesHealthcare DisparitiesHIV InfectionsHIV Long-Term SurvivorsHumansPreventive Health ServicesPrognosisProtective FactorsRace FactorsRisk AssessmentRisk FactorsSocial Determinants of HealthSocial MarginalizationSocioeconomic FactorsViral LoadVulnerable PopulationsConceptsHuman immunodeficiency virusCardiovascular diseaseComorbid human immunodeficiency virusNarrative reviewSocial determinantsRacial disparitiesCommon social determinantsEthnic disparities persistEthnic groupsCVD morbidityImmunodeficiency virusClinical practiceTranslation of researchClinical researchDisparities persistDiseaseHealthDisparitiesGroupMorbidityReviewPersonsPrevention
2019
Global Longitudinal Strain and Immune Status in Patients Living With Human Immunodeficiency Virus
Alenezi F, Bloomfield GS, Okeke NL, Velagapudi P, Abudaqa L, Ijioma N, Dunning A, Alajmi H, Clement ME, Shah SH, Naggie S, Velazquez EJ. Global Longitudinal Strain and Immune Status in Patients Living With Human Immunodeficiency Virus. The American Journal Of Cardiology 2019, 124: 966-971. PMID: 31371060, PMCID: PMC6887515, DOI: 10.1016/j.amjcard.2019.06.013.Peer-Reviewed Original ResearchConceptsLV ejection fractionHIV-1 RNA viral loadNormal LV ejection fractionRNA viral loadHuman immunodeficiency virusViral loadImmunodeficiency virusImmune statusGlobal longitudinal strain analysisNadir CD4 cell countPreclinical left ventricular dysfunctionDuke University Medical CenterCD4 cell countPlasma HIV RNALeft ventricular dysfunctionGlobal longitudinal strainCells/Longitudinal strain analysisUniversity Medical CenterCD4 cell count dataAbnormal GLSNadir CD4CD4 countHIV RNAVentricular dysfunction
2018
Determinants of Left Ventricular Hypertrophy and Diastolic Dysfunction in an HIV Clinical Cohort
Okeke NL, Alenezi F, Bloomfield GS, Dunning A, Clement ME, Shah SH, Naggie S, Velazquez EJ. Determinants of Left Ventricular Hypertrophy and Diastolic Dysfunction in an HIV Clinical Cohort. Journal Of Cardiac Failure 2018, 24: 496-503. PMID: 29964194, PMCID: PMC6231907, DOI: 10.1016/j.cardfail.2018.06.003.Peer-Reviewed Original ResearchConceptsLeft ventricular hypertrophyDiastolic dysfunctionTransthoracic echocardiogramVentricular hypertrophyHuman immunodeficiency virus-infected personsDuke University Medical CenterDefinite diastolic dysfunctionHIV Clinical CohortStructural myocardial abnormalitiesVirus-infected personsHuman immunodeficiency virusCells/University Medical CenterCD4 nadirsCD4 countViral suppressionPrimary outcomeImmune suppressionImmunodeficiency virusMyocardial abnormalitiesClinical cohortMedical CenterHigh riskImmune functionInfected personsDiastolic Dysfunction in Individuals With Human Immunodeficiency Virus Infection: Literature Review, Rationale and Design of the Characterizing Heart Function on Antiretroviral Therapy (CHART) Study
Butler J, Kalogeropoulos AP, Anstrom KJ, Hsue PY, Kim RJ, Scherzer R, Shah SJ, Shah SH, Velazquez EJ, Hernandez AF, Desvigne-Nickens P, Braunwald E. Diastolic Dysfunction in Individuals With Human Immunodeficiency Virus Infection: Literature Review, Rationale and Design of the Characterizing Heart Function on Antiretroviral Therapy (CHART) Study. Journal Of Cardiac Failure 2018, 24: 255-265. PMID: 29482027, PMCID: PMC5880702, DOI: 10.1016/j.cardfail.2018.02.001.Peer-Reviewed Original ResearchConceptsDiastolic dysfunctionAntiretroviral Therapy studyAntiretroviral therapyMyocardial fibrosisHeart functionMyocardial stressHuman immunodeficiency virus (HIV) infectionAge-matched control subjectsTherapy studiesLV diastolic dysfunctionVentricular systolic dysfunctionImmunodeficiency virus infectionCardiac magnetic resonance examinationHuman immunodeficiency virusMarkers of fibrosisImmune system activationSubclinical myocardial necrosisMagnetic resonance examinationOngoing inflammationSystolic dysfunctionAtrial functionCardiac involvementSystemic inflammationHIV individualsMyocardial effects
2015
Human Immunodeficiency Virus and Heart Failure in Low- and Middle-Income Countries
Bloomfield GS, Alenezi F, Barasa FA, Lumsden R, Mayosi BM, Velazquez EJ. Human Immunodeficiency Virus and Heart Failure in Low- and Middle-Income Countries. JACC Heart Failure 2015, 3: 579-590. PMID: 26251085, PMCID: PMC4530470, DOI: 10.1016/j.jchf.2015.05.003.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusHeart failureMiddle-income countriesImmunodeficiency virusChronic diseasesBurden of HIVTraditional cardiovascular risk factorsCommon cardiac diagnosesCardiovascular risk factorsLarge observational studiesLife expectancySuccessful combination therapyCare of peopleAntiretroviral therapyClinical characteristicsTreatment patternsSociety guidelinesCombination therapyRisk factorsClinical studiesObservational studyDiagnostic criteriaCardiac diagnosisHigh mortalityCardiac glycosides
2012
Conditions That Predispose to Pulmonary Hypertension and Right Heart Failure in Persons Exposed to Household Air Pollution in LMIC
Bloomfield GS, Lagat DK, Akwanalo OC, Carter EJ, Lugogo N, Vedanthan R, Velazquez EJ, Kimaiyo S, Sherman CB. Conditions That Predispose to Pulmonary Hypertension and Right Heart Failure in Persons Exposed to Household Air Pollution in LMIC. Global Heart 2012, 7: 249-259. PMID: 23687634, PMCID: PMC3653331, DOI: 10.1016/j.gheart.2012.06.015.Peer-Reviewed Original ResearchRight heart failurePulmonary hypertensionHousehold air pollutionHeart failureMiddle-income countriesAdverse cardiovascular health effectsRight heart functionHealth effectsHuman immunodeficiency virusCardiovascular health effectsPre-existing conditionsCommon comorbiditiesTuberculosis infectionImmunodeficiency virusCommon causeHypertensionCommon conditionRespiratory conditionsHeart functionCommon exposureMultifactorial natureLarge burdenAir pollutionSignificant exposureExposure