2017
Thyroid Nodule Diagnostic Markers in the Face of the New NIFTP Category: Time for a Reset?
Sahli Z, Umbricht C, Schneider E, Zeiger M. Thyroid Nodule Diagnostic Markers in the Face of the New NIFTP Category: Time for a Reset? Thyroid 2017, 27: 1393-1399. PMID: 28859553, DOI: 10.1089/thy.2017.0238.Peer-Reviewed Original ResearchConceptsCancer prevalenceSuspicious fine-needle aspiration (FNA) cytologyNon-invasive follicular thyroid neoplasmFine needle aspiration cytologyThyroid cancer prevalencePapillary-like nuclear featuresFollicular thyroid neoplasmPrecancerous lesionsDifferential diagnosisAspiration cytologyLatter diagnosisClinical validityThyroid neoplasmsOriginal validation studyMolecular panelDiagnostic markerMolecular testsNuclear featuresNIFTP reclassificationPrevalence
2016
Evaluation of the Effect of Diagnostic Molecular Testing on the Surgical Decision-Making Process for Patients With Thyroid Nodules
Noureldine S, Najafian A, Han P, Olson M, Genther D, Schneider E, Prescott J, Agrawal N, Mathur A, Zeiger M, Tufano R. Evaluation of the Effect of Diagnostic Molecular Testing on the Surgical Decision-Making Process for Patients With Thyroid Nodules. JAMA Otolaryngology - Head & Neck Surgery 2016, 142: 676-82. PMID: 27196108, DOI: 10.1001/jamaoto.2016.0850.Peer-Reviewed Original ResearchConceptsSurgical decision-making processMolecular testingSurgical consultationThyroid nodulesDiagnostic molecular testingEvidence of overtreatmentPertinent treatment optionsSurgical management algorithmRisk of malignancySurgical decision makingSurgical management planRadiological resultsStudy cohortSurgical managementTreatment algorithmProspective studyMean ageTreatment optionsMAIN OUTCOMEPatientsBethesda SystemHistopathology diagnosisControl groupCytopathology classificationHistopathology analysis
2015
Diagnostic Frequency Ratios Are Insufficient to Measure Laboratory Precision with The Bethesda System for Reporting Thyroid Cytopathology
Fazeli R, Schneider EB, Ali SZ, Zeiger MA, Olson MT. Diagnostic Frequency Ratios Are Insufficient to Measure Laboratory Precision with The Bethesda System for Reporting Thyroid Cytopathology. Acta Cytologica 2015, 59: 225-232. PMID: 26022342, DOI: 10.1159/000379738.Peer-Reviewed Original ResearchClinical Presentation of Patients with a Thyroid Follicular Neoplasm: Are there Preoperative Predictors of Malignancy?
Najafian A, Olson M, Schneider E, Zeiger M. Clinical Presentation of Patients with a Thyroid Follicular Neoplasm: Are there Preoperative Predictors of Malignancy? Annals Of Surgical Oncology 2015, 22: 3007-3013. PMID: 25564170, DOI: 10.1245/s10434-014-4324-z.Peer-Reviewed Original ResearchConceptsMalignant follicular neoplasmsFollicular thyroid neoplasmFollicular neoplasmThyroid neoplasmsMalignant follicular thyroid neoplasmsFinal pathologic resultsPresentation of patientsHistory of headMultivariate logistic regressionOdds of malignancyPredictors of malignancyThyroid follicular neoplasmsFollicular thyroid lesionsConcomitant hyperthyroidismMethodsConsecutive patientsNeck radiationPreoperative predictorsClinical predictorsClinical featuresClinical presentationMale sexTertiary hospitalResultsA totalPhysical examinationPathologic resultsHow Do Liquid-Based Preparations of Thyroid Fine-Needle Aspiration Compare with Conventional Smears? An Analysis of 5475 Specimens
Nagarajan N, Schneider EB, Ali SZ, Zeiger MA, Olson MT. How Do Liquid-Based Preparations of Thyroid Fine-Needle Aspiration Compare with Conventional Smears? An Analysis of 5475 Specimens. Thyroid 2015, 25: 308-313. PMID: 25420135, DOI: 10.1089/thy.2014.0394.Peer-Reviewed Original ResearchConceptsFine-needle aspirationLiquid-based preparationsLBP casesConventional smearsBenign diagnosisThyroid nodulesMalignant diagnosisHistology diagnosisAspirated materialClinical databaseSuspicious categoryCS casesInitial evaluationInadequate samplesDiagnosisNodule sizePatientsSecond reviewDiagnostic frequencySmearsInadequate rateHigher proportionLower proportionPivotal roleNodules
2014
Malignancy risk and reproducibility associated with atypia of undetermined significance on thyroid cytology
Mathur A, Najafian A, Schneider E, Zeiger M, Olson M. Malignancy risk and reproducibility associated with atypia of undetermined significance on thyroid cytology. Surgery 2014, 156: 1471-1476. PMID: 25218896, DOI: 10.1016/j.surg.2014.08.026.Peer-Reviewed Original ResearchConceptsMalignancy riskUndetermined significanceAvailable surgical pathologyDiagnosis of AUSTertiary care centerFocal nuclear atypiaFine-needle aspiration specimensHürthle cell neoplasmsOutside diagnosisMalignancy rateCare centerCell neoplasmsMorphologic predictorsHigh riskNuclear atypiaSurgical pathologyBethesda SystemAUS subcategoriesAspiration specimensGreater riskThyroid CytopathologyThyroid cytologyAtypiaDiagnosisAUSThe Impact of Molecular Testing on the Surgical Management of Patients with Thyroid Nodules
Aragon Han P, Olson M, Fazeli R, Prescott J, Pai S, Schneider E, Tufano R, Zeiger M. The Impact of Molecular Testing on the Surgical Management of Patients with Thyroid Nodules. Annals Of Surgical Oncology 2014, 21: 1862-1869. PMID: 24522987, DOI: 10.1245/s10434-014-3508-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsBiopsy, Fine-NeedleDecision Support TechniquesDNA Mutational AnalysisFemaleGene Expression ProfilingGTP PhosphohydrolasesHumansMaleMembrane ProteinsMiddle AgedPredictive Value of TestsProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-retRetrospective StudiesThyroid GlandThyroid NoduleConceptsSurgical managementPreoperative molecular testingMolecular testingThyroid nodulesRET/PTC translocationsPathology analysisMolecular testsSurgical management changesSurgical management decisionsTertiary care centerMajority of patientsSurgical management algorithmJohns Hopkins HospitalPostoperative pathology analysisGene expression classifierUnderwent surgerySurgical consultationThyroid surgeryMethodsClinical informationThyroid surgeonsCare centerFNA diagnosisPatientsSurgical practiceSurgical planning
2011
Predictive factors of malignancy in pediatric thyroid nodules
Roy R, Kouniavsky G, Schneider E, Allendorf JD, Chabot JA, Logerfo P, Dackiw AP, Colombani P, Zeiger MA, Lee JA. Predictive factors of malignancy in pediatric thyroid nodules. Surgery 2011, 150: 1228-1233. PMID: 22136845, DOI: 10.1016/j.surg.2011.09.023.Peer-Reviewed Original ResearchConceptsFine-needle aspiration biopsy specimensPediatric thyroid nodulesPositive predictive valuePalpable lymphadenopathyThyroid nodulesThyroid cancerFamily historyPredictive valueAspiration biopsy specimensPediatric thyroidectomyFinal pathologyClinical factorsClinicopathologic factorsRetrospective reviewTertiary hospitalPredictive factorsHypoechoic lesionsBiopsy specimensHypoechoic nodulesIndeterminate lesionsMalignancyFNAB resultsLymphadenopathyGreater riskCancerThe role of preoperative neck ultrasounds to assess lymph nodes in patients with suspicious or indeterminate thyroid nodules
Roy R, Kouniavsky G, Venkat R, Felger E, Shiue Z, Schneider E, Zeiger M. The role of preoperative neck ultrasounds to assess lymph nodes in patients with suspicious or indeterminate thyroid nodules. Journal Of Surgical Oncology 2011, 105: 601-605. PMID: 22006435, PMCID: PMC3715078, DOI: 10.1002/jso.22115.Peer-Reviewed Original ResearchConceptsIndeterminate thyroid nodulesLymph nodesFormal lymph node dissectionThyroid nodulesPreoperative neck ultrasoundSuspicious lymph nodesLymph node dissectionSize of tumorCervical ultrasoundIndeterminate thyroid cytologyNode dissectionMetastatic diseaseNeck ultrasoundSurgical managementClinicopathological variablesPreoperative ultrasoundSurgical approachPreoperative neckUltrasound findingsMale genderMedical recordsOperative approachSurgical ultrasoundPatientsThyroid cytology