2023
Leukocyte telomere length and DNA methylome as biomarkers of ovarian reserve and embryo aneuploidy: the intricate relationship between somatic and reproductive aging
Garg A, Seli E. Leukocyte telomere length and DNA methylome as biomarkers of ovarian reserve and embryo aneuploidy: the intricate relationship between somatic and reproductive aging. Fertility And Sterility 2023, 121: 26-33. PMID: 37979607, DOI: 10.1016/j.fertnstert.2023.11.011.Peer-Reviewed Original ResearchConceptsPoor ovarian responseLeukocyte telomere lengthOvarian reserveTelomere lengthAssisted Reproductive TechnologyOvarian responseFollicular somatic cellsMethylome changesDNA methylomePrevalence of infertilityDiminished ovarian reserveSomatic cellsCellular agingEpigenetic clocksDNA methylation ageReproductive potentialReproductive declineOvarian agingSurrogate biomarkerCommon causeMethylomeART outcomesChronologic ageEmbryo aneuploidyReproductive function
2009
Noninvasive metabolomic profiling as an adjunct to morphology for noninvasive embryo assessment in women undergoing single embryo transfer
Seli E, Vergouw CG, Morita H, Botros L, Roos P, Lambalk CB, Yamashita N, Kato O, Sakkas D. Noninvasive metabolomic profiling as an adjunct to morphology for noninvasive embryo assessment in women undergoing single embryo transfer. Fertility And Sterility 2009, 94: 535-542. PMID: 19589524, DOI: 10.1016/j.fertnstert.2009.03.078.Peer-Reviewed Original ResearchConceptsSingle embryo transferDay 3 embryosDay 2Embryo transferImplantation rateEmbryo culture mediumMetabolomic profilingPositive fetal cardiac activityAssisted reproductive technology programViability indexNoninvasive metabolomic profilingFetal cardiac activityReproductive technology programHuman embryo culture mediaRetrospective studyMAIN OUTCOMEDay 3Morphology gradeBlinded analysisCardiac activityReproductive potentialEmbryo assessmentCulture mediumBlinded validationWomen
2008
Noninvasive metabolomic profiling of human embryo culture media using Raman spectroscopy predicts embryonic reproductive potential: a prospective blinded pilot study
Scott R, Seli E, Miller K, Sakkas D, Scott K, Burns DH. Noninvasive metabolomic profiling of human embryo culture media using Raman spectroscopy predicts embryonic reproductive potential: a prospective blinded pilot study. Fertility And Sterility 2008, 90: 77-83. PMID: 18281045, DOI: 10.1016/j.fertnstert.2007.11.058.Peer-Reviewed Original ResearchConceptsMetabolomic profilingProspective blinded pilot studyNoninvasive metabolomic profilingEmbryonic reproductive potentialBlinded pilot studyReproductive technology programCharacteristic curve analysisHuman embryo culture mediaOverall diagnostic accuracyViability indexImplantation rateEmbryo culture mediumMAIN OUTCOMEDay 3Noninvasive assessmentDay 5Culture mediumDiagnostic accuracyPilot studyCurve analysisSimilar findingsReproductive potentialRapid noninvasive assessmentDelivery rateHuman embryos